Estimation of energy requirements in persons with severe central nervous system impairment

1995 ◽  
Vol 126 (5) ◽  
pp. 828-832 ◽  
Author(s):  
Linda G. Bandini ◽  
Heidi Puelzl-Quinn ◽  
Julie A. Morelli ◽  
Naomi K. Fukagawa
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Energy Requirements ◽  
Central Nervous System Impairment

Central nervous system therapy for lysosomal storage disorders

2008 ◽  
Vol 24 (3-4) ◽  
pp. E12 ◽  
Author(s):  
Gregory M. Enns ◽  
Stephen L. Huhn
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Dysfunction ◽  
Lysosomal Storage Disorders ◽  
Lysosomal Storage ◽  
Systemic Involvement ◽  
Enzyme Replacement ◽  
System Therapy ◽  
Central Nervous System Impairment ◽  
Storage Disorders

✓ Most lysosomal storage disorders are characterized by progressive central nervous system impairment, with or without systemic involvement. Affected individuals have an array of symptoms related to brain dysfunction, the most devastating of which is neurodegeneration following a period of normal development. The blood–brain barrier has represented a significant impediment to developing therapeutic approaches to treat brain disease, but novel approaches—including enzyme replacement, small-molecule, gene, and cell-based therapies—have given children afflicted by these conditions and those who care for them hope for the future.

Ratio of central nervous system to body metabolism in vertebrates: its constancy and functional basis

1981 ◽  
Vol 241 (3) ◽  
pp. R203-R212 ◽  
Author(s):  
J. W. Mink ◽  
R. J. Blumenschine ◽  
D. B. Adams
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Control System ◽  
Functional Relationship ◽  
Muscle Metabolism ◽  
Vertebrate Evolution ◽  
Energy Requirements ◽  
Vertebrate Species ◽  
The Central Nervous System ◽  
Large Animals

We present and document an hypothesis that healthy adults of most vertebrate species use 2-8% of their basal metabolism for the central nervous system (CNS). This relationship is constant across all classes of vertebrates, as we found by examining data from 42 species, including 3 fish, 3 amphibia, 2 reptiles, 6 birds, and 28 mammals. To explain its constancy, we hypothesize that an optimal functional relationship between the energy requirements of an animal's executor system (muscle metabolism) and its control system (CNS metabolism) was established early in vertebrate evolution. Three types of exceptional cases are discussed in terms of the hypothesis: very large animals, domesticated animals, and primates.

Long-Term Ventilation in Children with Severe Central Nervous System Impairment

1997 ◽  
Vol 17 (03) ◽  
pp. 239-248 ◽  
Author(s):  
Ronald Perkin ◽  
Robert Orr ◽  
Stephen Ashwal ◽  
James Walters ◽  
Lawrence Tomasi ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Impairment ◽  
Long Term Ventilation
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