110: Intra-Prostate Cell Phenotyping: A Predominance of NK, NKT Cells and Upregulation of CD45RC and CD161A in CD4+ T Cells

2004 ◽  
Vol 171 (4S) ◽  
pp. 29-29
Author(s):  
Eugene V. Vykhovanets ◽  
Susan R. Marengo ◽  
Martin I. Resnick ◽  
Gregory T. Maclennan
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Nkt Cells ◽  
Prostate Cell

IL-4 inducibility in NKT cells, naïve CD4+ T cells and TCR-γ δ T cells

2007 ◽  
Vol 14 (4) ◽  
pp. 533-538 ◽  
Author(s):  
Yi-Ting Chen ◽  
John T. Kung
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Nkt Cells

scholarly journals Enhanced oxidative phosphorylation in NKT cells is essential for their survival and function

2019 ◽  
Vol 116 (15) ◽  
pp. 7439-7448 ◽  
Author(s):  
Ajay Kumar ◽  
Kalyani Pyaram ◽  
Emily L. Yarosz ◽  
Hanna Hong ◽  
Costas A. Lyssiotis ◽  
...  
Keyword(s):  
T Cells ◽  
Glucose Metabolism ◽  
Cell Survival ◽  
Glucose Uptake ◽  
Cell Fate ◽  
Cd4 T Cells ◽  
Cell Function ◽  
Nkt Cells ◽  
Nkt Cell ◽  
And Function

Cellular metabolism and signaling pathways are key regulators to determine conventional T cell fate and function, but little is understood about the role of cell metabolism for natural killer T (NKT) cell survival, proliferation, and function. We found that NKT cells operate distinct metabolic programming from CD4 T cells. NKT cells are less efficient in glucose uptake than CD4 T cells with or without activation. Gene-expression data revealed that, in NKT cells, glucose is preferentially metabolized by the pentose phosphate pathway and mitochondria, as opposed to being converted into lactate. In fact, glucose is essential for the effector functions of NKT cells and a high lactate environment is detrimental for NKT cell survival and proliferation. Increased glucose uptake and IFN-γ expression in NKT cells is inversely correlated with bacterial loads in response to bacterial infection, further supporting the significance of glucose metabolism for NKT cell function. We also found that promyelocytic leukemia zinc finger seemed to play a role in regulating NKT cells’ glucose metabolism. Overall, our study reveals that NKT cells use distinct arms of glucose metabolism for their survival and function.

scholarly journals CXCL10-Producing Mucosal CD4+ T Cells, NK Cells, and NKT Cells Are Associated with Chronic Colitis in IL-10−/− Mice, Which Can Be Abrogated by Anti-CXCL10 Antibody Inhibition

2008 ◽  
Vol 28 (1) ◽  
pp. 31-43 ◽  
Author(s):  
Udai P. Singh ◽  
Shailesh Singh ◽  
Rajesh Singh ◽  
Yingzi Cong ◽  
Dennis D. Taub ◽  
...  
Keyword(s):  
T Cells ◽  
Nk Cells ◽  
Cd4 T Cells ◽  
Nkt Cells ◽  
Chronic Colitis ◽  
Antibody Inhibition

scholarly journals Nonredundant Roles for CD1d-restricted Natural Killer T Cells and Conventional CD4+ T Cells in the Induction of Immunoglobulin E Antibodies in Response to Interleukin 18 Treatment of Mice

2003 ◽  
Vol 197 (8) ◽  
pp. 997-1005 ◽  
Author(s):  
Tomohiro Yoshimoto ◽  
Booki Min ◽  
Takaaki Sugimoto ◽  
Nobuki Hayashi ◽  
Yuriko Ishikawa ◽  
...  
Keyword(s):  
T Cells ◽  
Natural Killer ◽  
Cd4 T Cells ◽  
Immunoglobulin E ◽  
Allergic Inflammation ◽  
Cd40 Ligand ◽  
Nkt Cells ◽  
Class Ii ◽  
Natural Killer T

Interleukin (IL)-18 synergizes with IL-12 to promote T helper cell (Th)1 responses. Somewhat paradoxically, IL-18 administration alone strongly induces immunoglobulin (Ig)E production and allergic inflammation, indicating a role for IL-18 in the generation of Th2 responses. The ability of IL-18 to induce IgE is dependent on CD4+ T cells, IL-4, and signal transducer and activator of transcription (stat)6. Here, we show that IL-18 fails to induce IgE both in CD1d−/− mice that lack natural killer T (NKT) cells and in class II−/− mice that lack conventional CD4+ T cells. However, class II−/− mice reconstituted with conventional CD4+ T cells show the capacity to produce IgE in response to IL-18. NKT cells express high levels of IL-18 receptor (R)α chain and produce significant amounts of IL-4, IL-9, and IL-13, and induce CD40 ligand expression in response to IL-2 and IL-18 stimulation in vitro. In contrast, conventional CD4+ T cells express low levels of IL-18Rα and poorly respond to IL-2 and IL-18. Nevertheless, conventional CD4+ T cells are essential for B cell IgE responses after the administration of IL-18. These findings indicate that NKT cells might be the major source of IL-4 in response to IL-18 administration and that conventional CD4+ T cells demonstrate their helper function in the presence of NKT cells.

scholarly journals Invariant NKT Cells Suppress CD8+ T-Cell–Mediated Allergic Contact Dermatitis Independently of Regulatory CD4+ T Cells

2013 ◽  
Vol 133 (4) ◽  
pp. 980-987 ◽  
Author(s):  
Anne Goubier ◽  
Marc Vocanson ◽  
Claire Macari ◽  
Gaelle Poyet ◽  
André Herbelin ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Cd4 T Cells ◽  
Cd8 T Cell ◽  
Nkt Cells ◽  
Invariant Nkt Cells ◽  
Allergic Contact

scholarly journals CD4+ NKT Cells, But Not Conventional CD4+ T Cells, Are Required to Generate Efferent CD8+ T Regulatory Cells Following Antigen Inoculation in an Immune-Privileged Site

2003 ◽  
Vol 171 (3) ◽  
pp. 1266-1271 ◽  
Author(s):  
Takahiko Nakamura ◽  
Koh-Hei Sonoda ◽  
Douglas E. Faunce ◽  
Jenny Gumperz ◽  
Takashi Yamamura ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
T Regulatory Cells ◽  
Nkt Cells ◽  
Regulatory Cells ◽  
Privileged Site

scholarly journals The Interleukin-4 Enhancer CNS-2 Is Regulated by Notch Signals and Controls Initial Expression in NKT Cells and Memory-Type CD4 T Cells

Immunity ◽  
2006 ◽  
Vol 24 (6) ◽  
pp. 689-701 ◽  
Author(s):  
Shinya Tanaka ◽  
Jun Tsukada ◽  
Wataru Suzuki ◽  
Katsuhiko Hayashi ◽  
Kenji Tanigaki ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Nkt Cells ◽  
Interleukin 4 ◽  
Memory Type

scholarly journals P87 Vascular Adhesion Protein-1 promotes increases in liver infiltrating CD4+ T cells and NKT cells and induction of fibrogenesis in steatohepatitis

Gut ◽  
2011 ◽  
Vol 60 (Suppl 2) ◽  
pp. A40-A40
Author(s):  
L. C. Claridge ◽  
C. J. Weston ◽  
E. L. Haughton ◽  
N. Westerlund ◽  
G. M. Reynolds ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Nkt Cells ◽  
Adhesion Protein ◽  
Vascular Adhesion ◽  
Vascular Adhesion Protein 1

scholarly journals Antibody responses to glycolipid‐borne carbohydrates require CD4 + T cells but not CD1 or NKT cells

2011 ◽  
Vol 89 (4) ◽  
pp. 574-574
Author(s):  
Dale Christiansen ◽  
Hilary A Vaughan ◽  
Julie Milland ◽  
Natalie Dodge ◽  
Effie Mouhtouris ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Nkt Cells ◽  
Antibody Responses
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