Medicinal plants are the oldest form of healthcare known to mankind. Antioxidants are considered to be important in
fighting against the damages done by the free radicals produced due to oxidative stress. Antiepileptic drugs help to
minimize or to irradiate the convulsive shocks and seizures as a result of abnormal and excessive nerve cell activity.
Standardized, well established in vitro and in vivo methods are available for experimental evaluation of antioxidant and
antiepileptic agents. A step wise procedure from in vitro and in vivo seems reasonable to reduce the large quantity of
potential drugs to a few promising agents for further clinical testing. This review has focused on some herbal drugs with
both antioxidant and antiepileptic property such as Brassica nigra, Bacopa monniera, Ficus religiosa, Convolvulus
pluricalis, Jatamansi and Acorus calamus.