A sequential injection spectrophotometric method for the determination of penicillamine in pharmaceutical products by complexation with iron(III) in acidic media

Talanta ◽  
2003 ◽  
Vol 61 (2) ◽  
pp. 221-231 ◽  
Author(s):  
F Suliman
Keyword(s):  
Spectrophotometric Method ◽  
Pharmaceutical Products ◽  
Sequential Injection ◽  
Acidic Media

Design and optimization of a chemometrics-assisted spectrophotometric method for the simultaneous determination of levodopa and carbidopa in pharmaceutical products

2005 ◽  
Vol 543 (1-2) ◽  
pp. 192-198 ◽  
Author(s):  
Patricia C. Damiani ◽  
Andrea C. Moschetti ◽  
Adrián J. Rovetto ◽  
Fernando Benavente ◽  
Alejandro C. Olivieri
Keyword(s):  
Simultaneous Determination ◽  
Spectrophotometric Method ◽  
Pharmaceutical Products ◽  
Design And Optimization

scholarly journals Spectrophotometric determination of methyldopa in pharmaceutical formulations

2005 ◽  
Vol 30 (3) ◽  
pp. 23-28 ◽  
Author(s):  
P. R. S. Ribeiro ◽  
L. Pezza ◽  
H. R. Pezza
Keyword(s):  
Correlation Coefficient ◽  
Spectrophotometric Method ◽  
Confidence Level ◽  
Low Cost ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Pharmaceutical Products ◽  
Complexation Reaction ◽  
Excellent Correlation

A new, simple, precise, rapid and low-cost spectrophotometric method for methyldopa determination in pharmaceutical preparations is described. This method is based on the complexation reaction of methyldopa with molybdate. Absorbance of the resulting yellow coloured product is measured at 410 nm. Beer's Law is obeyed in a concentration range of 50 - 200 µg ml-1 methyldopa with an excellent correlation coefficient (r = 0.9999). No interference was observed from common excipients in formulations. The results show a simple, accurate, fast and readily applied method to the determination of methyldopa in pharmaceutical products. The analytical results obtained for these products by the proposed method are in agreement with those of the Brazilian Pharmacopoeia procedure at 95% confidence level.

Sign in / Sign up

Export Citation Format

Share Document