Identification and characterization of contact sites between thromboxane A2 receptor and Gαq important for signal transduction impairment

1999 ◽  
Vol 59 (1-6) ◽  
pp. 226
Author(s):  
Valerie Capra ◽  
G. Enrico Rovati ◽  
Aida Habib ◽  
Jacques Maclouf
Keyword(s):  
Signal Transduction ◽  
Thromboxane A2 ◽  
Thromboxane A2 Receptor ◽  
Contact Sites ◽  
Identification And Characterization

scholarly journals Identification and characterization of endonuclein binding proteins: evidence of modulatory effects on signal transduction and chaperone activity

2009 ◽  
Vol 10 (1) ◽  
pp. 34 ◽  
Author(s):  
Maja Ludvigsen ◽  
Morten Østergaard ◽  
Henrik Vorum ◽  
Christian Jacobsen ◽  
Bent Honoré
Keyword(s):  
Signal Transduction ◽  
Binding Proteins ◽  
Chaperone Activity ◽  
Identification And Characterization

scholarly journals A Genetic Analysis of Glucocorticoid Receptor Signaling: Identification and Characterization of Ligand-Effect Modulators in Saccharomyces cerevisiae

Genetics ◽  
2000 ◽  
Vol 156 (3) ◽  
pp. 963-972
Author(s):  
Raquel Sitcheran ◽  
Roger Emter ◽  
Anastasia Kralli ◽  
Keith R Yamamoto
Keyword(s):  
Signal Transduction ◽  
Glucocorticoid Receptor ◽  
Cellular Response ◽  
Transmembrane Protein ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Ligand Effect ◽  
Yeast Genetic ◽  
Identification And Characterization

Abstract To find novel components in the glucocorticoid signal transduction pathway, we performed a yeast genetic screen to identify ligand-effect modulators (LEMs), proteins that modulate the cellular response to hormone. We isolated several mutants that conferred increased glucocorticoid receptor (GR) activity in response to dexamethasone and analyzed two of them in detail. These studies identify two genes, LEM3 and LEM4, which correspond to YNL323w and ERG6, respectively. LEM3 is a putative transmembrane protein of unknown function, and ERG6 is a methyltransferase in the ergosterol biosynthetic pathway. Analysis of null mutants indicates that LEM3 and ERG6 act at different steps in the GR signal transduction pathway.

scholarly journals High-Level Expression, Purification and Characterization of a Constitutively Active Thromboxane A2 Receptor Polymorphic Variant

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e76481 ◽  
Author(s):  
Bing Xu ◽  
Raja Chakraborty ◽  
Markus Eilers ◽  
Shyamala Dakshinamurti ◽  
Joe D. O’Neil ◽  
...  
Keyword(s):  
Thromboxane A2 ◽  
Polymorphic Variant ◽  
Purification And Characterization ◽  
High Level Expression ◽  
Thromboxane A2 Receptor ◽  
High Level ◽  
Constitutively Active
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