Distinct T cell receptor diversity and integrative analyses of clinically defined high-grade serous ovarian cancer

2021 ◽  
Vol 162 ◽  
pp. S138
Author(s):  
Sanghoon Lee ◽  
Li Zhao ◽  
Latasha Little ◽  
Shannon Westin ◽  
Amir Jazaeri ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Integrative Analyses

scholarly journals Distinct T cell receptor repertoire diversity of clinically defined high-grade serous ovarian cancer treatment subgroups

iScience ◽  
2021 ◽  
Vol 24 (2) ◽  
pp. 102053
Author(s):  
Sanghoon Lee ◽  
Li Zhao ◽  
Latasha D. Little ◽  
Shannon N. Westin ◽  
Amir A. Jazarei ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Receptor Repertoire ◽  
Repertoire Diversity ◽  
T Cell Receptor Repertoire ◽  
Cell Receptor Repertoire

Treatment with carboplatin and taxane chemotherapy increases T-cell receptor (TCR) clonality in high-grade serous ovarian cancer (HGSOC)

2017 ◽  
Vol 145 ◽  
pp. 20-21
Author(s):  
K. LaVigne ◽  
P. Cybulska ◽  
T. Walther ◽  
R.O. Emerson ◽  
M. Vignali ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Taxane Chemotherapy

scholarly journals Integrated Molecular Profiling Studies to Characterize the Cellular Origins of High-Grade Serous Ovarian Cancer

2018 ◽  
Author(s):  
Kate Lawrenson ◽  
Marcos A.S. Fonseca ◽  
Felipe Segato ◽  
Janet M. Lee ◽  
Rosario I. Corona ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Cells ◽  
Tumor Development ◽  
Molecular Profiling ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Cell Of Origin ◽  
Ovarian Cancers ◽  
Integrative Analyses ◽  
Ovarian Surface Epithelial

AbstractHistorically, high-grade serous ovarian cancers (HGSOCs) were thought to arise from ovarian surface epithelial cells (OSECs) but recent data implicate fallopian tube secretory epithelial cells (FTSECs) as the major precursor. We performed transcriptomic and epigenomic profiling to characterize molecular similarities between OSECs, FTSECs and HGSOCs. Transcriptomic signatures of FTSECs were preserved in most HGSOCs reinforcing FTSECs as the predominant cell-of-origin; though an OSEC-like signature was associated with increased chemosensitivity (Padj= 0.03) and was enriched in proliferative-type tumors, suggesting a dualistic model for HGSOC origins. More super-enhancers (SEs) were shared between FTSECs and HGSOCs than between OSECS and HGSOCs (P< 2.2 × 10−16). SOX18, ELF3 and EHF transcription factors (TFs) coincided with HGSOC SEs and represent putative novel drivers of tumor development. Our integrative analyses support a predominantly fallopian origin for HGSOCs and indicate tumorigenesis may be driven by different TFs according to cell-of-origin.

scholarly journals Biophysicochemical motifs in T cell receptor sequences as a potential biomarker for high-grade serous ovarian carcinoma

PLoS ONE ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. e0229569 ◽  
Author(s):  
Jared Ostmeyer ◽  
Elena Lucas ◽  
Scott Christley ◽  
Jayanthi Lea ◽  
Nancy Monson ◽  
...  
Keyword(s):  
T Cell ◽  
Ovarian Carcinoma ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
High Grade ◽  
Serous Ovarian Carcinoma ◽  
Potential Biomarker

Adjuvant radiation for patients (pts) with high-grade serous ovarian cancer (HGSC) and T-cell infiltration.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 5543-5543
Author(s):  
Aalok Kumar ◽  
Cyril Blake Gilks ◽  
Blaise Clarke ◽  
Christina Aquino-Parsons ◽  
Jessica N. McAlpine ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
T Cell ◽  
Cell Infiltration ◽  
Adjuvant Radiation ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
T Cell Infiltration

scholarly journals T-Cell Receptor Therapy in the Treatment of Ovarian Cancer: A Mini Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Jessica W. Y. Wu ◽  
Sudiksha Dand ◽  
Lachlan Doig ◽  
Anthony T. Papenfuss ◽  
Clare L. Scott ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
T Cell ◽  
T Cell Receptor ◽  
Treatment Options ◽  
Cell Receptor ◽  
Hematologic Malignancies ◽  
Adoptive T Cell Therapy ◽  
T Cell Therapy ◽  
Cell Based Therapy ◽  
Car T

Ovarian cancer, in particularly high-grade serous ovarian cancer (HGSOC) and ovarian carcinosarcoma (OCS), are highly aggressive and deadly female cancers with limited treatment options. These tumors are generally unresponsive to immune check-point inhibitor (ICI) therapy and are referred to as immunologically “cold” tumors. Cell-based therapy, in particular, adoptive T-cell therapy, is an alternative immunotherapy option that has shown great potential, especially chimeric antigen receptor T cell (CAR-T) therapy in the treatment of hematologic malignancies. However, the efficacy of CAR-T therapy in solid tumors has been modest. This review explores the potential of another cell-based therapy, T-cell receptor therapy (TCR-T) as an alternate treatment option for immunological “cold” OC and OCS tumors.

Correlation between Wnt signaling and T-cell infiltration in high-grade serous ovarian cancer

2019 ◽  
Vol 154 ◽  
pp. 72
Author(s):  
W. Goldsberry ◽  
R.A. Phillips ◽  
A.M. Montgomery ◽  
A.A. Katre ◽  
D.W. Doo ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
T Cell ◽  
Wnt Signaling ◽  
Cell Infiltration ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
T Cell Infiltration
Sign in / Sign up

Export Citation Format

Share Document