Progesterone treatment during the early follicular phase of the menstrual cycle: Effects on smoking behavior in women

2001 ◽  
Vol 69 (1-2) ◽  
pp. 299-304 ◽  
Author(s):  
Mehmet Sofuoglu ◽  
David A Babb ◽  
Dorothy K Hatsukami
Keyword(s):  
Menstrual Cycle ◽  
Smoking Behavior ◽  
Follicular Phase ◽  
Progesterone Treatment ◽  
Early Follicular Phase

The Effect of Progesterone on the Haemostatic Mechanism

1997 ◽  
Vol 77 (01) ◽  
pp. 105-108 ◽  
Author(s):  
M Blombäck ◽  
B-M Landgren ◽  
Y Stiernholm ◽  
O Andersson
Keyword(s):  
Menstrual Cycle ◽  
Coagulation Factors ◽  
Follicular Phase ◽  
Hemostatic Effect ◽  
Progesterone Treatment ◽  
Normal Menstrual Cycle ◽  
Early Follicular Phase ◽  
Slight Rise

SummaryThe hemostatic effect of progesterone administered vaginally at a dose of 100 mg twice a day throughout one menstrual cycle was investigated and compared with the coagulation factors in one untreated normal menstrual cycle in 15 women. The progesterone treatment resulted in a 20-fold progesterone rise in the early follicular phase from 1.2 nmol/1 in the pretreatment control cycle to levels between 26 and 29 nmol/1 during treatment. Ovulation was completely suppressed in seven women while eight women showed a slight rise in progesterone on treatment days 20 to 25 not compatible with the rise which could have been expected if ovulation had occurred. The effects found on haemostasis during progesterone treatment varied with the menstrual cycle and were so small that they could as well be due to chance and not to treatment.

Changes in hormonal concentrations after different heavy-resistance exercise protocols in women

1993 ◽  
Vol 75 (2) ◽  
pp. 594-604 ◽  
Author(s):  
W. J. Kraemer ◽  
S. J. Fleck ◽  
J. E. Dziados ◽  
E. A. Harman ◽  
L. J. Marchitelli ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Rest Period ◽  
Follicular Phase ◽  
Total Testosterone ◽  
Factor I ◽  
Rest Periods ◽  
Early Follicular Phase ◽  
In Series ◽  
Heavy Resistance Exercise ◽  
Blood Variables

Nine eumenorrheic women (age 24.11 +/- 4.28 yr) performed each of six randomly assigned heavy-resistance protocols (HREPs) on separate days during the early follicular phase of the menstrual cycle. The HREPs consisted of two series [series 1 (strength, S) and series 2 (hypertrophy, H)] of three protocols, each using identically ordered exercises controlled for load [5 vs. 10 repetitions maximum (RM)], rest period length (1 vs. 3 min), and total work (J) within each three-protocol series. Blood measures were determined pre-, mid- (after 4 of 8 exercises), and postexercise (0, 5, 15, 30, 60, 90, 120 min and 24 and 48 h). In series 1, a significant (P < 0.05) reduction in growth hormone (GH) was observed at 90 min postexercise for all three protocols. In series 2, the 10-RM protocol with 1-min rest periods (H10/1) produced significant increases above rest in GH concentrations at 0, 5, and 15 min postexercise, and the H10/1 and H5/1 protocols demonstrated significant reductions at 90 and 120 min postexercise. Cortisol demonstrated significant increases in response to the S10/3 protocol at 0 min, to the H10/1 protocol at midexercise and at 0 and 5 min postexercise, and to the H5/1 protocol at 5 and 15 min postexercise. No significant changes were observed in total insulin-like growth factor I, total testosterone, urea, or creatinine for any of the HREPs. Significant elevations in whole blood lactate and ammonia along with significant reductions in blood glucose were observed. Hormonal and metabolic blood variables measured in the early follicular phase of the menstrual cycle varied in response to different HREPs. The most dramatic increases above resting concentrations were observed with the H10/1 protocol, indicating that the more glycolytic HREPs may stimulate greater GH and cortisol increases.

scholarly journals Sex Differences and Menstrual Cycle Phase-Dependent Modulation of Craving for Cigarette: An fMRI Pilot Study

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Adrianna Mendrek ◽  
Laurence Dinh-Williams ◽  
Josiane Bourque ◽  
Stéphane Potvin
Keyword(s):  
Sex Differences ◽  
Menstrual Cycle ◽  
Parietal Lobe ◽  
Follicular Phase ◽  
Cycle Phase ◽  
Functional Neuroanatomy ◽  
Early Follicular Phase ◽  
Hormonal Fluctuations ◽  
Women And Girls ◽  
The Right

While overall more men than women smoke cigarettes, women and girls take less time to become dependent after initial use and have more difficulties quitting the habit. One of the factors contributing to these differences may be that women crave cigarettes more than men and that their desire to smoke is influenced by hormonal fluctuations across the menstrual cycle. Therefore, the purpose of the present study was twofold: (a) to examine potential sex/gender differences in functional neuroanatomy of craving and to (b) delineate neural correlates of cigarette cravings in women across their menstrual cycle. Fifteen tobacco-smoking men and 19 women underwent a functional MRI during presentation of neutral and smoking-related images, known to elicit craving. Women were tested twice: once during early follicular phase and once during midluteal phase of their menstrual cycle. The analysis did not reveal any significant sex differences in the cerebral activations associated with craving. Nevertheless, the pattern of activations in women varied across their menstrual cycle with significant activations in parts of the frontal, temporal, and parietal lobe, during follicular phase, and only limited activations in the right hippocampus during the luteal phase.

Influence of Ischemia-reperfusion Injury on Endothelial Function in Men and Women with Similar Serum Estradiol Concentrations

2021 ◽  
Author(s):  
Sophie Lalande ◽  
Holden W. Hemingway ◽  
Caitlin P. Jarrard ◽  
Amy M. Moore ◽  
Albert H. Olivencia-Yurvati ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Endothelial Function ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Circulatory Arrest ◽  
Duplex Ultrasound ◽  
Follicular Phase ◽  
Serum Estradiol ◽  
Early Follicular Phase ◽  
Artery Flow

Prior data suggest that relative to the early follicular phase, women in the late follicular phase are protected against endothelial ischemia-reperfusion (I/R) injury when estradiol concentrations are highest. In addition, endothelial I/R injury is consistently observed in men with naturally low endogenous estradiol concentrations that are similar to women in the early follicular phase. Therefore, the purpose of this study was to determine if the vasodeleterious effect of I/R injury differs between women in the early follicular phase of the menstrual cycle and age-matched men. We tested the hypothesis that I/R injury would attenuate endothelium-dependent vasodilation to the same extent in women and age-matched men with similar circulating estradiol concentrations. Endothelium-dependent vasodilation was assessed via brachial artery flow-mediated dilation (duplex ultrasound) in young healthy men (N = 22) and women (N = 12) before (pre-I/R) and immediately after I/R injury (post-I/R), which was induced via 20 min of arm circulatory arrest followed by 20 min reperfusion. Serum estradiol concentrations did not differ between sexes (men, 115.0 ± 33.9 pg ml-1 vs. women, 90.5 ± 40.8 pg ml-1; P = 0.2). The magnitude by which I/R injury attenuated endothelium-dependent vasodilation did not differ between men (pre-I/R, 5.4 ± 2.4 % vs. post-I/R 3.0 ± 2.7 %;) and women (pre-I/R, 6.1 ± 2.8 % vs. post-I/R 3.7 ± 2.7 %; P = 0.9). Our data demonstrate that I/R injury similarly reduces endothelial function in women in the early follicular phase of the menstrual cycle and age-matched men with similar estradiol concentrations.

scholarly journals CRP at early follicular phase of menstrual cycle can cause misinterpretation for cardiovascular risk assessment

2015 ◽  
Vol 7 (4) ◽  
pp. 143-146 ◽  
Author(s):  
Asli Yarci Gursoy ◽  
Gamze Sinem Caglar ◽  
Mine Kiseli ◽  
Emre Pabuccu ◽  
Tuba Candar ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Cardiovascular Risk ◽  
Menstrual Cycle ◽  
Follicular Phase ◽  
Cardiovascular Risk Assessment ◽  
Early Follicular Phase

scholarly journals T141. EFFECTS OF MENSTRUAL CYCLE ON RESTING STATE FUNCTIONAL CONNECTIVITY IN SCHIZOPHRENIA: A FUNCTIONAL MRI STUDY

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S284-S285
Author(s):  
Handan Noyan ◽  
Andaç Hamamcı ◽  
Zeynep Fırat ◽  
Ayşegül Sarsılmaz Oygen ◽  
Alp Üçok
Keyword(s):  
Menstrual Cycle ◽  
Functional Connectivity ◽  
Resting State ◽  
Ovarian Hormones ◽  
Follicular Phase ◽  
Cycle Phase ◽  
Resting State Functional Connectivity ◽  
Brain Functions ◽  
Early Follicular Phase ◽  
The Mean

Abstract Background The menstrual cycle is a favorable model for examining the influence of ovarian hormones on cognition, emotion and brain functions. Ovarian hormones have substantial effects on task-related brain activity, but their impacts on functional connectivity at rest have been investigated by a few studies conducted with healthy individuals and these pre-existing findings are inconsistent. As for schizophrenia, different influences of ovarian hormones were reported. For instance, the estrogen hypothesis of schizophrenia has suggested that estrogen plays a neuroprotective role in the pathophysiology of this disorder. The present study investigates resting state functional connectivity (RS-FC) alterations related to menstrual cycle phase and/or hormone levels in patients with schizophrenia and healthy controls and aims to contribute to the understanding of the effects of ovarian hormones on the pathogenesis of schizophrenia and brain functions. Methods The study was conducted with 13 women with schizophrenia (the mean of age: 32 ± 7.67) and 13 healthy women (the mean of age: 30.08 ± 7.27). Resting state functional Magnetic Resonance Imaging (fMRI) scanning, as well as hormonal and clinical assessments, were applied to each participant twice, during two menstrual cycle phases: early follicular (Days 2–6; low estrogen/progesterone) and mid-luteal (Days 20–22; high estrogen/progesterone). The serum hormone levels of estradiol, progesterone, prolactin (only in the patients), follicle-stimulating and luteinizing were assessed. The clinical assessment interviews included the Brief Psychiatric Rating Scales, the Clinical Global Impression (only for the patients), the Global Assessment of Functioning and the Calgary Depression Rating Scale for Schizophrenia (for both groups). Results Our findings revealed that no cycle phase-related alterations existed in RS-FC in both groups. However, specific correlations between each hormone and RS-FC were found in both cycle phases for two groups. In the patients, estrogen was positively correlated with the auditory network (AN) connectivity in the left amygdala at the early follicular phase. In the controls, the positive correlations to progesterone were found in the precuneus for the connectivity of the posterior default mode network (DMN) and the left-frontoparietal network (FPN) during the early follicular phase. Also, progesterone was negatively correlated with the executive control network (ECN) connectivity in the right superior frontal gyrus at the mid-luteal phase in the controls. Furthermore, the patients had lower progesterone levels during the mid-luteal phase compared to the controls (p&lt;0.05). The severity of the psychotic symptoms of the patients didn’t change between the cycle phases. Discussion To our knowledge, this is the first study to examine the influence of the menstrual cycle on the brain’s RS-FC in schizophrenia. Our results indicated that the effects of the menstrual cycle on RS-FC were more prominent in the controls rather than the patients with schizophrenia; and that the findings for the patient group may be associated with the additional mechanisms responsible from schizophrenia. This might imply that differentiating the menstrual cycle effects is difficult in a complex disorder such as schizophrenia. The results obtained from the controls are consistent with the previous findings indicating that the menstrual cycle effects might be associated with the connectivity of the DMN and cognition-related networks. Moreover, our results suggested that estrogen might have a modulating effect on the intrinsic functional connectivity changes in the patients, while progesterone, might mediate to that in the controls.

scholarly journals Ferritin status impact on hepcidin response to endurance exercise in physically active women along different phases of the menstrual cycle

2021 ◽  
Vol 38 (1) ◽  
pp. 22-27
Author(s):  
VM Alfaro Magallanes ◽  
L Barba Moreno ◽  
AB Peinado
Keyword(s):  
Menstrual Cycle ◽  
Follicular Phase ◽  
Cycle Phase ◽  
Menstrual Cycle Phase ◽  
Sexual Hormones ◽  
Physically Active ◽  
Post Exercise ◽  
Before And After ◽  
Early Follicular Phase ◽  
Response To Exercise

Serum ferritin has been proposed as a predictor of hepcidin concentrations in response to exercise. However, this fact has not been studied in physically-active women. Therefore, the main objective of this study was to analyse the hepcidin response at different ferritin status before and after running exercise in physically active females. Fifteen eumenorrheic women performed a 40-min running protocol at 75% of VO2peak speed in different menstrual cycle phases (early-follicular phase, mid-follicular phase and luteal phase). Blood samples were collected pre-exercise, 0h post-exercise and 3h post-exercise. For statistics, participants were divided into two groups according to their pre-exercise ferritin levels (<20 and ≥20 μg/L). Through menstrual cycle, hepcidin was lower in both early follicular phase (p=0.024; 64.81±22.48 ng/ml) and mid-follicular phase (p=0.007; 64.68±23.91 ng/ml) for <20 μg/L ferritin group, in comparison with ≥20 μg/L group (81.17±27.89 and 79.54±22.72 ng/ml, respectively). Hepcidin showed no differences between both ferritin groups in either pre-exercise, 0h post-exercise and 3h post-exercise. Additionally, no association between pre-exercise ferritin and hepcidin levels 3h post-exercise (r=-0.091; p=0.554) was found. Menstrual cycle phase appears to influence hepcidin levels depending on ferritin reserves. In particular, physically-active females with depleted ferritin reserves seems to present lower hepcidin levels during the early-follicular phase and mid-follicular phase. However, no association between ferritin and hepcidin levels was found in this study. Hence, ferritin levels alone may not be a good predictor of hepcidin response to exercise in this population. Multiple factors such as sexual hormones, training loads and menstrual bleeding must be taken into account.

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