Potential role of interleukin-1 in reproduction of a squamate reptile (Chalcides chalcides)

Placenta ◽  
1996 ◽  
Vol 17 (5-6) ◽  
pp. A48
Author(s):  
L. Paulesu ◽  
R. Romagnoli ◽  
G. Ghiarar
Keyword(s):  
Potential Role ◽  
Interleukin 1 ◽  
Squamate Reptile

Role of polymorphism of the interleukin-1B gene and other genetic polymorphisms in the aetiology of root resorption in patients receiving orthodontic treatment

2017 ◽  
Vol 13 (1) ◽  
pp. 36-42
Author(s):  
Marzena Makowska-Kaczmarska ◽  
Anna Okoń ◽  
Elżbieta Olszewska
Keyword(s):  
Genetic Polymorphisms ◽  
Gene Polymorphisms ◽  
Orthodontic Treatment ◽  
Potential Role ◽  
Root Resorption ◽  
Interleukin 1 ◽  
Dna Testing ◽  
Individual Gene ◽  
Global Population

Aim. The aim of the work was to present the latest directions in the research on gene polymorphisms in the global population and to discuss their potential role in the pathogenesis of root resorption during orthodontic treatment. Material and methods. A review of the literature in Polish and English from the years 1990–2015 was conducted using PubMed/MEDLINE databases and the results of studies kept in the database of the National Centre for Biotechnology Information were used. Key words used: genetics of root resorption, genetic polymorphism, interleukin-1B. Results. 19 articles were analysed. Special attention was placed on the latest studies on the human genome, especially focused on gene polymorphisms in the global population. Summary. Pathogenesis of root resorption during orthodontic treatment is complex. Its background is undoubtedly genetic. Gene polymorphism is important. The role of polymorphism of the interleukin-1B gene and other genes in the interleukin-1 cluster draws special attention. Identification of genetic factors that play an important role in the aetiology of root resorption may in the future help to identify patients susceptible to such complications even before the beginning of orthodontic treatment. Potential possibilities of DNA testing in clinical practice are enormous. The role of individual gene polymorphisms in the pathogenesis of root resorption has not been yet explained in detail and further multicentre studies are necessary. At this stage of studies no reliable markers have been detected in order to predict which patients would develop this complication. (Makowska- Kaczmarska M, Okoń A, Olszewska E. Role of polymorphism of the interleukin-1B gene and other genetic polymorphisms in the aetiology of root resorption in patients receiving orthodontic treatment. Orthod Forum 2017; 13: 36-42).

Potential Role of Hyaluronic Acid on Bone in Osteoarthritis: Matrix Metalloproteinases, Aggrecanases, and RANKL Expression are Partially Prevented by Hyaluronic Acid in Interleukin 1-stimulated Osteoblasts

2014 ◽  
Vol 41 (5) ◽  
pp. 945-954 ◽  
Author(s):  
Zvezdana Mladenovic ◽  
Anne-Sophie Saurel ◽  
Francis Berenbaum ◽  
Claire Jacques
Keyword(s):  
Hyaluronic Acid ◽  
Matrix Metalloproteinases ◽  
Potential Role ◽  
Proteolytic Enzymes ◽  
Interleukin 1 ◽  
Nuclear Factor Κb ◽  
Mrna Levels ◽  
Receptor Activator ◽  
Polymerase Chain

Objective.To determine the effect of hyaluronic acid (HA) on proteolytic enzymes and bone remodeling mediators induced by interleukin 1β (IL-1β) and related to cartilage catabolism in murine osteoblasts.Methods.Osteoblasts were obtained from Swiss mice and cultured for 3 weeks. HA-treated osteoblasts were incubated with 100 μg/ml HA during the last week of culture, then stimulated with IL-1β (10 ng/ml) for 24 h. The expression of matrix metalloproteinases 3 and 13 (MMP-3 and MMP-13), ADAMTS-4 and ADAMTS-5, tissue inhibitor of metalloproteinases (TIMP), osteoprotegerin, and receptor activator of nuclear factor-κB ligand (RANKL) was determined by real-time polymerase chain reaction. MMP-3 and MMP-13 release was assessed by Western blot analysis.Results.IL-1β increased the mRNA levels of MMP-3 and MMP-13 and ADAMTS-4 and ADAMTS-5 and release of MMP-3 and MMP-13. Seven days of HA treatment significantly prevented the IL-1β-increased mRNA levels of MMP-3 (−61%, p < 0.01), MMP-13 (−56%, p < 0.01), ADAMTS-4 (−58%, p < 0.05), ADAMTS-5 (−52%, p < 0.01), and RANKL (−49%, p < 0.05), but not TIMP. As well, IL-1β-induced production of MMP-3 and MMP-13 was inhibited, by 27% (p < 0.01) and 40% (p < 0.01), respectively.Conclusion.In an inflammatory context in murine osteoblasts, HA can inhibit the expression of MMP and ADAMTS. Because HA can counteract the production of these mediators in chondrocytes, its beneficial effect in osteoarthritis may be due to its action on cartilage and subchondral bone.

scholarly journals The Potential Role of SOCS-3 in the Interleukin-1 -Induced Desensitization of Insulin Signaling in Pancreatic Beta-Cells

Diabetes ◽  
2004 ◽  
Vol 53 (Supplement 3) ◽  
pp. S97-S103 ◽  
Author(s):  
B. Emanuelli ◽  
M. Glondu ◽  
C. Filloux ◽  
P. Peraldi ◽  
E. Van Obberghen
Keyword(s):  
Beta Cells ◽  
Insulin Signaling ◽  
Pancreatic Beta Cells ◽  
Potential Role ◽  
Interleukin 1

scholarly journals Effect of Indigofera oblongifolia on the Hepatic Oxidative Status and Expression of Inflammatory and Apoptotic Genes during Blood-Stage Murine Malaria

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Mohamed A. Dkhil ◽  
Esam M. Al-Shaebi ◽  
Saleh Al-Quraishy
Keyword(s):  
Potential Role ◽  
Interleukin 1 ◽  
B Cell Lymphoma ◽  
Disease Spread ◽  
Hepatic Inflammation ◽  
Stress Markers ◽  
Apoptotic Genes ◽  
Indigofera Oblongifolia ◽  
Necrosis Factor

Malaria is a dangerous disease spread across several countries. Recent studies have focused on medicinal plants to discover alternative agents to the currently used drugs for malaria treatment. Here, we investigated the potential role of Indigofera oblongifolia leaf extract (IE) on hepatic inflammation in mice with Plasmodium chabaudi-infected erythrocytes. Female C57BL/6 mice were divided into three groups. The first group served as a control noninfected group, while the second and third groups were intraperitoneally injected with 106 erythrocytes parasitized by P. chabaudi. Mice from the third group were treated daily with a dose of 100 mg/kg of IE for 7 days. IE significantly reduced the number of leukocytes and apoptotic cells. The numbers of CD68-positive cells decreased in the livers of mice from the treatment group. Moreover, IE raised the hepatic antioxidant levels (glutathione and catalase) and reduced the levels of hepatic oxidative stress markers (malondialdehyde, nitric oxide, and reactive oxygen species). IE regulated some functions of the genes related to immune responses, including apoptotic genes (B-cell lymphoma-2, Bax, and caspase-3) and cytokine genes (interleukin-1β (IL-1β), IL-6, interferon-γ, and tumor necrosis factor-α). Therefore, IE exerts significant effects against malaria and protects the liver from injury caused by P. chabaudi via antioxidant and anti-inflammatory ways.

Potential role of interleukin-1 as the trigger for diffuse intravascular coagulation in acute nonlymphoblastic leukemia

1988 ◽  
Vol 84 (2) ◽  
pp. 240-250 ◽  
Author(s):  
Federico Cozzolino ◽  
Maria Torcia ◽  
Anna Miliani ◽  
Anna M. Carossino ◽  
Rosanna Giordani ◽  
...  
Keyword(s):  
Potential Role ◽  
Interleukin 1 ◽  
Intravascular Coagulation ◽  
Diffuse Intravascular Coagulation ◽  
Acute Nonlymphoblastic Leukemia

Potential Role of Interleukin-1 in the Development of Bronchopulmonary Dysplasia

1996 ◽  
Vol 16 (5) ◽  
pp. 365-373 ◽  
Author(s):  
M. SUZANNE RINDFLEISCH ◽  
JEFFREY D. HASDAY ◽  
VICKI TACIAK ◽  
KAREN BRODERICK ◽  
ROSE M. VISCARDI
Keyword(s):  
Bronchopulmonary Dysplasia ◽  
Potential Role ◽  
Interleukin 1

scholarly journals Interleukin 10 (IL-10) upregulates IL-1 receptor antagonist production from lipopolysaccharide-stimulated human polymorphonuclear leukocytes by delaying mRNA degradation.

1994 ◽  
Vol 179 (5) ◽  
pp. 1695-1699 ◽  
Author(s):  
M A Cassatella ◽  
L Meda ◽  
S Gasperini ◽  
F Calzetti ◽  
S Bonora
Keyword(s):  
Receptor Antagonist ◽  
Polymorphonuclear Leukocytes ◽  
Potential Role ◽  
Inflammatory Responses ◽  
Interleukin 1 ◽  
Interleukin 10 ◽  
Mrna Stabilization ◽  
Human Polymorphonuclear Leukocytes ◽  
Necrosis Factor

Polymorphonuclear leukocytes (PMN) have been identified as cells capable of producing a number of pro- and antiinflammatory cytokines in response to specific agonists. Previously, we showed that tumor necrosis factor (TNF), interleukin-1 beta (IL-1 beta), and IL-8, are produced by PMN after stimulation with agonists, such as lipopolysaccharide (LPS). In this study, we demonstrate that LPS is also a potent stimulus for the mRNA expression and release of the IL-1 receptor antagonist (IL-1ra). In addition, we show that the release of IL-1ra from LPS-stimulated PMN is markedly potentiated in the presence of IL-10 (from two to threefold after 18 h of stimulation). Moreover, we observed that this upregulation of IL-1ra production by IL-10 in LPS-stimulated PMN took place through IL-1ra mRNA stabilization. Indeed, the half-life of IL-1ra mRNA was prolonged in PMN stimulated in the presence of IL-10 and LPS, as compared with cells stimulated with LPS alone. That IL-10 selectively upregulates IL-1ra production in LPS-activated PMN, while it inhibits the production of IL-1 beta, TNF, and IL-8 under the same conditions, suggests that IL-10 may be an important physiologic regulator of cytokine production from PMN, and emphasizes the potential role of IL-10 in inflammatory responses.

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