Non-malignant haematological disease (thalassemia, sickle cell) or multiple myeloma)

Abstract 1. The findings obtained by the study of splenic aspirations in 140 patients are presented. Diagnostically they were most helpful in myeloid metaplasia, lymphoma, kala-azar, and Gaucher’s disease. 2. The findings were of particular theoretical interest in multiple myeloma and sickle cell anemia. This method of investigation could be extended to elucidating further the role of the spleen in other diseases. 3. No morbidity was encountered in this series. If certain precautions are observed, splenic puncture is a safe procedure, and should be undertaken in patients with undiagnosed splenomegaly.

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Multiple myeloma in a patient with sickle cell anemia. Interacting effects on blood viscosity

The American Journal of Medicine ◽

10.1016/0002-9343(75)90279-x ◽

1975 ◽

Vol 59 (4) ◽

pp. A98

Keyword(s):

Multiple Myeloma ◽

Sickle Cell ◽

Sickle Cell Anemia ◽

Blood Viscosity

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Chronic disorders

10.1093/med/9780199666041.003.0025 ◽

2014 ◽

Author(s):

Anthea Hatfield

Keyword(s):

Multiple Myeloma ◽

Liver Disease ◽

Muscular Dystrophy ◽

Sickle Cell Disease ◽

Myasthenia Gravis ◽

Drug Addiction ◽

Sickle Cell ◽

Psychiatric Disease ◽

Cell Disease ◽

Chronic Disorders

Diseases not covered elsewhere are found in this chapter. The subjects are AIDS, alcoholism, drug addiction, epilepsy, liver disease, multiple myeloma, musculoskeletal disease, myasthenia gravis, muscular dystrophy, Paget’s disease, Parkinson’s disease, psychiatric disease, phaeochromocytoma, porphyria, sickle cell disease, smoking, stroke, hypothyroidism, and many others.

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Chronic disorders

The Complete Recovery Room Book ◽

10.1093/med/9780198846840.003.0025 ◽

2020 ◽

pp. 387-402

Author(s):

Anne Craig ◽

Anthea Hatfield

Keyword(s):

Multiple Myeloma ◽

Liver Disease ◽

Muscular Dystrophy ◽

Sickle Cell Disease ◽

Myasthenia Gravis ◽

Drug Addiction ◽

Sickle Cell ◽

Psychiatric Disease ◽

Cell Disease ◽

Chronic Disorders

Diseases not covered elsewhere are found in this chapter. The subjects are AIDS, alcoholism, drug addiction, epilepsy, liver disease, multiple myeloma, musculoskeletal disease, myasthenia gravis, muscular dystrophy, Paget’s disease, Parkinson’s disease, psychiatric disease, phaeochromocytoma, porphyria, sickle cell disease, smoking, stroke, hypothyroidism, and many others.

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Challenges of Managing Multiple Myeloma Patients with Sickle Cell Disease: A Case Report and Review of Literature

American Journal of Case Reports ◽

10.12659/ajcr.933470 ◽

2021 ◽

Vol 22 ◽

Author(s):

Maroun Bou Zerdan ◽

Maria Julia Diacovo ◽

Chakra P. Chaulagain

Keyword(s):

Multiple Myeloma ◽

Case Report ◽

Sickle Cell Disease ◽

Sickle Cell ◽

Review Of Literature ◽

Cell Disease

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The orientation of sickle hemoglobin fibers within fascicles

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100104066 ◽

1988 ◽

Vol 46 ◽

pp. 400-401

Author(s):

Christopher A. Miller ◽

Bridget Carragher ◽

William A. McDade ◽

Robert Josephs

Keyword(s):

Sickle Cell ◽

Sickle Cell Anemia ◽

Relative Orientation ◽

Unit Cell ◽

Red Cell ◽

High Ph ◽

Sickle Hemoglobin ◽

Polar Crystal ◽

Helical Configuration

Highly ordered bundles of deoxyhemoglobin S (HbS) fibers, termed fascicles, are intermediates in the high pH crystallization pathway of HbS. These fibers consist of 7 Wishner-Love double strands in a helical configuration. Since each double strand has a polarity, the odd number of double strands in the fiber imparts a net polarity to the structure. HbS crystals have a unit cell containing two double strands, one of each polarity, resulting in a net polarity of zero. Therefore a rearrangement of the double strands must occur to form a non-polar crystal from the polar fibers. To determine the role of fascicles as an intermediate in the crystallization pathway it is important to understand the relative orientation of fibers within fascicles. Furthermore, an understanding of fascicle structure may have implications for the design of potential sickling inhibitors, since it is bundles of fibers which cause the red cell distortion responsible for the vaso-occlusive complications characteristic of sickle cell anemia.

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Proteasome inhibitors as therapeutics

Essays in Biochemistry ◽

10.1042/bse0410205 ◽

2005 ◽

Vol 41 ◽

pp. 205-218

Author(s):

Constantine S. Mitsiades ◽

Nicholas Mitsiades ◽

Teru Hideshima ◽

Paul G. Richardson ◽

Kenneth C. Anderson

Keyword(s):

Multiple Myeloma ◽

Drug Class ◽

Proteasome Inhibitors ◽

Cell Cycle Regulators ◽

Current State ◽

Intracellular Mechanism ◽

Ubiquitin Proteasome ◽

Proteasome Pathway ◽

Hodgkin's Lymphomas ◽

Clinical Research Data

The ubiquitin–proteasome pathway is a principle intracellular mechanism for controlled protein degradation and has recently emerged as an attractive target for anticancer therapies, because of the pleiotropic cell-cycle regulators and modulators of apoptosis that are controlled by proteasome function. In this chapter, we review the current state of the field of proteasome inhibitors and their prototypic member, bortezomib, which was recently approved by the U.S. Food and Drug Administration for the treatment of advanced multiple myeloma. Particular emphasis is placed on the pre-clinical research data that became the basis for eventual clinical applications of proteasome inhibitors, an overview of the clinical development of this exciting drug class in multiple myeloma, and a appraisal of possible uses in other haematological malignancies, such non-Hodgkin's lymphomas.

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