scholarly journals Risk factors associated with age-related macular degeneration

Ophthalmology ◽  
2000 ◽  
Vol 107 (12) ◽  
pp. 2224-2232 ◽  
2013 ◽  
Vol 61 (12) ◽  
pp. 722 ◽  
Author(s):  
Baskaran Vallikannan ◽  
BangeraSheshappa Mamatha ◽  
Bhatiwada Nidhi ◽  
ChamrajnagarAnantharajiah Padmaprabhu ◽  
Prabhu Pallavi

2014 ◽  
Vol 92 (7) ◽  
pp. 662-669 ◽  
Author(s):  
Maja G Erke ◽  
Geir Bertelsen ◽  
Tunde Peto ◽  
Anne K Sjølie ◽  
Haakon Lindekleiv ◽  
...  

2018 ◽  
Vol 136 (5) ◽  
pp. 473 ◽  
Author(s):  
Valentine Saunier ◽  
Bénédicte M. J. Merle ◽  
Marie-Noëlle Delyfer ◽  
Audrey Cougnard-Grégoire ◽  
Marie-Bénédicte Rougier ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maiko Maruyama-Inoue ◽  
Tatsuya Inoue ◽  
Shaheeda Mohamed ◽  
Yoko Kitajima ◽  
Shoko Ikeda ◽  
...  

AbstractThe purpose of this study was to report the incidence of elevated intraocular pressure (IOP) after intravitreal injection (IVI) of anti-vascular endothelial growth factor (VEGF) in Japanese patients with age-related macular degeneration (AMD). A retrospective study of chart review of patients who underwent ≥ 10 intravitreal anti-VEGF injections between April 2009 and December 2019 was conducted. Elevated IOP was defined as IOP ≥ 25 mmHg at one visit. Cases with elevated IOP resulting from IVI were identified. Furthermore, the association between elevated IOP and some parameters, as the risk factors that influence elevated IOP, was investigated. A total of 402 eyes of 370 patients were included in this study. Twenty-eight eyes of 26 patients (7.0%) were identified as cases with elevated IOP after IVI. The mean time of elevation after baseline was 50.6 ± 26.5 months. History of glaucoma (p = 0.021; odds ratio, 5.85), treatment modality (p = 0.019; odds ratio, 6.32), and total number of injections (p = 0.003; odds ratio, 1.03) were significantly associated with elevated IOP. A late complication of elevated IOP is associated with IVI in patients with AMD. Particularly, history of glaucoma and treat and extend regimen with frequent injections were found to be risk factors of elevated IOP.


2021 ◽  
Vol 22 (3) ◽  
pp. 1170
Author(s):  
Arunbalaji Pugazhendhi ◽  
Margaret Hubbell ◽  
Pooja Jairam ◽  
Balamurali Ambati

Neovascular age-related macular degeneration (exudative or wet AMD) is a prevalent, progressive retinal degenerative macular disease that is characterized by neovascularization of the choroid, mainly affecting the elderly population causing gradual vision impairment. Risk factors such as age, race, genetics, iris color, smoking, drinking, BMI, and diet all play a part in nvAMD’s progression, with anti-vascular endothelial growth factor (anti-VEGF) therapy being the mainstay of treatment. Current therapeutic advancements slow the progression of the disease but do not cure or reverse its course. Newer therapies such as gene therapies, Rho-kinase inhibitors, and levodopa offer potential new targets for treatment.


2020 ◽  
Vol 4 (7) ◽  
pp. 662-672 ◽  
Author(s):  
Usha Chakravarthy ◽  
Clare C. Bailey ◽  
Peter H. Scanlon ◽  
Martin McKibbin ◽  
Rehna S. Khan ◽  
...  

Ophthalmology ◽  
2014 ◽  
Vol 121 (9) ◽  
pp. 1766-1772 ◽  
Author(s):  
Fridbert Jonasson ◽  
Diana E. Fisher ◽  
Gudny Eiriksdottir ◽  
Sigurdur Sigurdsson ◽  
Ronald Klein ◽  
...  

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