Mutagenicity of cyclopenta-fused polynuclear aromatic hydrocarbons and a non-polar fraction from a fuel combustion sample in a Salmonella forward mutation assay without exogenous metabolic activation

The essential oil of peppermint and one of its natural constituents, (R)-(+)-pulegone, are approved flavorings added to food worldwide. (R)-(+)-Pulegone and peppermint oil were tested separately in two independent bacterial reverse mutation assays according to Organisation for Economic Co-operation and Development Guideline 471. Both flavorings did not produce any evidence of mutagenicity up to cytotoxic concentrations in either the presence or the absence of exogenous metabolic activation.

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Multi-alkylated Polynuclear Aromatic Hydrocarbons of Tobacco Smoke: Separation and Identification

Beiträge zur Tabakforschung International/Contributions to Tobacco Research ◽

10.2478/cttr-2013-0452 ◽

1978 ◽

Vol 9 (4) ◽

Cited By ~ 2

Author(s):

M. E. Snook ◽

R. F. Severson ◽

R. F. Arrendale ◽

H. C. Higman ◽

O. T. Chortyk

Keyword(s):

Liquid Chromatography ◽

Cigarette Smoke ◽

Aromatic Hydrocarbons ◽

Ultra Violet ◽

Polynuclear Aromatic Hydrocarbons ◽

Gel Chromatography ◽

Cigarette Smoke Condensate ◽

Gas And Liquid Chromatography ◽

Silicic Acid Chromatography ◽

Derivatives Of

AbstractThe methyl, multi-methyl, and ethyl derivatives of the polynuclear aromatic hydrocarbons (PAH) of cigarette smoke condensate (CSC) were isolated from the neutrals by silicic acid chromatography, solvent partitioning and gel chromatography. The procedure yielded a relatively pure PAH isolate amenable to further identifications. The multi-alkylated PAH were concentrated in the early gel fractions with parent and higher ring PAH found in subsequent gel fractions. It was shown that CSC is very rich in alkylated PAH, and their successful identification required extensive use of gas and liquid chromatography and ultra-violet and GC - mass spectrometric techniques. High-pressure liquid chromatography (HPLC) separated individual isomers of the alkylated PAH in complex GC peaks. PAH from indene to pentamethylchrysene were found. This report concludes our identification studies on the PAH of CSC and complements our two previous reports in this journal. Collectively, our studies have identified approximately 1000 PAH of cigarette smoke condensate and have led to the development of methods for the routine quantitation of PAH in smalI quantities of cigarette smoke condensate.

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Spectrophotometry Measurement of Polynuclear Aromatic Hydrocarbons in Hamilton Harbour Sediments

Water Quality Research Journal ◽

10.2166/wqrj.1991.001 ◽

1991 ◽

Vol 26 (1) ◽

pp. 1-16 ◽

Cited By ~ 4

Author(s):

T.P. Murphy ◽

H. Brouwer ◽

M.E. Fox ◽

E. Nagy

Keyword(s):

Aromatic Hydrocarbons ◽

Total Concentration ◽

Coal Tar ◽

Sediment Cores ◽

Polynuclear Aromatic Hydrocarbons ◽

Mass Spectrometry Analysis ◽

Gas Chromatography Mass Spectrometry ◽

Near Surface ◽

Spectrometry Analysis ◽

Hamilton Harbour

Abstract Eighty-one sediment cores were collected to determine the extent of coal tar contamination in a toxic area of Hamilton Harbour. Over 800 samples were analyzed by a UV spectrophotometric technique that was standardized with gas chromatography/mass spectrometry analysis. The coal tar distribution was variable. The highest concentrations were near the Stelco outfalls and the Hamilton-Wentworth combined sewer outfalls. The total concentration of the 16 polynuclear aromatic hydrocarbons (PAHs) in 48,300 m3 of near-surface sediments exceeded 200 µg/g.

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