Overproduction of neutrophil radical oxygen species correlates with negative symptoms in schizophrenic patients: parallel studies on neutrophil chemotaxis, superoxide production and bactericidal activity

2003 ◽  
Vol 121 (2) ◽  
pp. 123-132 ◽  
Author(s):  
Pinkhas Sirota ◽  
Ronit Gavrieli ◽  
Baruch Wolach
2007 ◽  
Author(s):  
Sabrina D. O'Kennon ◽  
Josh McGuire ◽  
Kerry Hubel ◽  
Katy Lonergan ◽  
Rowena G. Gomez ◽  
...  

1988 ◽  
Vol 3 (2) ◽  
pp. 125-130
Author(s):  
D.M. Dieterle ◽  
M. Ackenheil ◽  
H.P. Kapfhammer ◽  
F. Müller-Spahn

RésuméZotepine was studied in 15 schizophrenic patients over a period of 28 days with regard to its antipsychotic efficacy, effect on negative schizophrenic symptoms, tolerability and adverse effects. Nine patients received Zotepine in a high dosage of 230 mg/die±52 mg, 6 patients in a low dosage of 168 mg/die ± 18 mg. Two patients receiving the high dosage dropped out after 21 days because of worsening of symptomatology and suicide attempts. Zotepine had rapid antipsychotic effects with sedative properties during the initial days of treatment. Minimal adverse effects and extra-pyramidal motor disturbances as well as dose-dependent positive effects on negative schizophrenie symptoms were found.


2013 ◽  
Vol 142-143 ◽  
pp. 662-667 ◽  
Author(s):  
Luis Domínguez Sánchez ◽  
Sébastien Francis Michel Taxt-Lamolle ◽  
Eli Olaug Hole ◽  
André Krivokapić ◽  
Einar Sagstuen ◽  
...  

2015 ◽  
Vol 22 (2) ◽  
pp. 65-69 ◽  
Author(s):  
Eman Ibrahim Abo El Ella ◽  
Nivert Zaki Hashim ◽  
Mahmoud Mamdouh Elhabiby ◽  
Sherien A. Khalil ◽  
Iman Shorab ◽  
...  

2001 ◽  
Vol 16 (6) ◽  
pp. 354-361 ◽  
Author(s):  
S. Moritz ◽  
B. Andresen ◽  
D. Jacobsen ◽  
K. Mersmann ◽  
U. Wilke ◽  
...  

SummaryThere is widespread evidence that schizophrenic symptomatology is best represented by three syndromes (positive, negative, disorganized). Both the disorganized and negative syndrome have been found to correlate with several neurocognitive dysfunctions. However, previous studies investigated samples predominantly treated with typical neuroleptics, which frequently induce parkinsonian symptoms that are hard to disentangle from primary negative symptoms and may have inflated correlations with neurocognition. A newly developed psychopathological instrument called the Positive and Negative and Disorganized Symptoms Scale (PANADSS) was evaluated in 60 schizophrenic patients. Forty-seven participants treated with atypical neuroleptics performed several neurocognitive tasks.A three-factor solution of schizophrenic symptomatology emerged. Negative symptomatology was associated with diminished creative verbal fluency and digit span backward, whereas disorganization was significantly correlated with impaired Stroop, WCST and Trail-Making Test B performance.Data suggest that disorganization is associated with tasks that demand executive functioning. Previous findings reporting correlations between negative symptomatology and neurocognition may have been confounded by the adverse consequences of typical neuroleptics.


2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Walda Isna Nisa

Abstrak. Skizofrenia merupakan kelainan psikiatrik kronis dan termasuk gangguan mental berat yang ditunjukkan dengan beberapa simtom negatif seperti pada gejala depresi. Depresi merupakan kondisi emosional yang biasa ditandai dengan kesedihan yang mendalam, perasaan tidak berarti dan bersalah, menarik diri dari orang lain, tidak dapat tidur, kehilangan selera makan, kehilangan hasrat seksual dan minat  dalam beraktivitas. Penelitian ini bertujuan mengurangi gejala depresi pada pasien gangguan skizofren dengan intervensi Positive Psychotherapy. Metode penelitian yang digunakan adalah eksperimen dengan One-Group Pretest-Posttest Design. Subjek penelitian ini adalah laki-laki berusia 22 tahun yang mengalami gangguan skizofrenia dengan gejala depresi. Instrumen yang digunakan adalah Tes Grafis, Wartegg, Wais, WWQ, SSCT dan skala BDI-II. Teknik analisis data menggunakan kuantitatif non parametik dengan uji Wilcoxon pada SPSS versi 23. Hasil penelitian menunjukkan intervensi Positive Psychotherapy mampu mengurangi gejala depresi pada subjek. Subjek sudah mampu melakukan aktivitas sehari-hari  dan berinteraksi terlibat dalam  kegiatan sosial. Hal ini didukung oleh motivasi subjek untuk sembuh namun subjek kurang percaya diri menjalani kehidupannya. Dukungan keluarga dan lingkungan sangat positif sehingga dapat meningkatkan motivasi subjek dalam mengurangi gejala depresi yang dialami.Kata Kunci :  Positive Psychotherapy, Gejala Depresi, Gangguan SkizofreniaAbstract. Schizophrenia is a chronic psychiatric disorder and includes severe mental disorders as indicated by several negative symptoms such as symptoms of depression. Depression is an emotional condition that is usually characterized by deep sadness, feeling insignificant and guilty, withdrawing from others, unable to sleep, losing appetite, losing sexual desire and interest in activities. This study aims to reduce depression symptoms in schizophrenic patients with Positive Psychotherapy intervention. The research method used was an experiment with One-Group Pretest-Posttest Design. The subjects of this study were 22-year-old men who experienced schizophrenia with symptoms of depression. The instruments used are Graphic Test, Wartegg, Wais, WWQ, SSCT and BDI-II scale. The data analysis technique used quantitative non parametics with Wilcoxon test on SPSS version 23. The results of the study showed that Positive Psychotherapy was able to reduce depressive symptoms in the subject. Subjects are able to carry out daily activities and interact involved in social activities. This is supported by the motivation of the subject to recover but the subject lacks confidence in living his life. Family and environmental support is very positive so it can increase the motivation of the subject in reducing the symptoms of depression experienced.Keywords: Positive Psychotherapy, Symptoms of Depression, Schizophrenic Disorders


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