The relationship between diastolic function of the left ventricle and QT dispersion in patients with myocardial infarction

1999 ◽  
Vol 69 (3) ◽  
pp. 245-249 ◽  
Author(s):  
Piotr Szymański ◽  
Maciej Świa̧tkowski ◽  
Joanna Rezler ◽  
Andrzej Budaj
Keyword(s):  
Myocardial Infarction ◽  
Left Ventricle ◽  
Diastolic Function ◽  
Qt Dispersion ◽  
The Relationship

scholarly journals FEATURES OF LEFT VENTRICLE DIASTOLIC FUNCTION IN PATIENTS WITH NON Q-WAVE MYOCARDIAL INFARCTION AFTER PERCUTANEOUS INTERVENTION

2017 ◽  
Vol 9 (2) ◽  
pp. 44-50
Author(s):  
D A Khomyakova ◽  
S A Sayganov ◽  
Y N Grishkin
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Left Ventricle ◽  
Diastolic Function ◽  
Percutaneous Intervention ◽  
Infarct Related Artery ◽  
Group 2 ◽  
Grade 3 ◽  
Higher Sensitivity ◽  
Q Wave

Aim: To make natural development more exact to state the value of scientific prognostication of dia- stolic dysfunction with acute myocardial infarction without Q-wave after percutaneous intervention.materials and methods: 95 patients were subjected to coronography and revascularization of in- farct-related artery. The patients were divided into 2 groups depending on angiographic results with single and multivessel affection. during first 48 hours from the beginning of the disease they were under ECHO examination.Results: Left ventricle affections dF data were revealed relatively to heaviness of affection in cor- onary vessels without reliable differences in local and global contractility. Primordialy the 1 group contained 14 (54%) patients of I grade dd, 5 (19%) with II grade, 1 (8%) with III grade, 6 (19%) without dd. A year later: 18 (70%) with I grade dd, 3 (12%) with II, patients with III grade were not redictered, 5 (18%) without dd. In group 2 within first 48 hours 37 (54%) patients had I grade,25 (36%) II grade, 7 (10%) III grade. In a year there were 46 (67%) with I grade, 13 (19%) II grade, 3 (4%) with III grade dd, 7 (10%) without dd.Conclusions: Obtained data indicate of a higher sensitivity dependently dF ischemia.In contrast to myocardial infarction group with coronary bloodstream fully restored within short terms, in group with multivessel affections a more heavy dd data preserved longer, in spite of infarct related artery revascularization. Also unfavourable events were revealed.

QT dispersion and cardiac involvement in children with Familial Mediterranean fever

2011 ◽  
Vol 22 (4) ◽  
pp. 404-409 ◽  
Author(s):  
Bülent Koca ◽  
Özgür Kasapçopur ◽  
Süleyman Bakari ◽  
Emine Sönmez ◽  
Funda Öztunç ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Left Ventricle ◽  
Diastolic Function ◽  
Ventricular Arrhythmias ◽  
Qt Dispersion ◽  
Hereditary Disease ◽  
Non Invasive ◽  
Mediterranean Fever ◽  
Systolic And Diastolic Function

AbstractFamilial Mediterranean fever is a hereditary disease characterised by recurrent and self-terminated attacks of fever and polyserositis. An earlier study found that adult patients of Familial Mediterranean fever had an abnormally longer QT dispersion and corrected QT dispersion, markers for ventricular arrhythmogenicity. QT dispersion is a simple non-invasive arrhythmogenic marker that can be used to assess homogeneity of cardiac repolarisation; however, it has not been studied in children with Familial Mediterranean fever before. The aim of this study was to assess QT dispersion and corrected QT dispersion, and their relationship with systolic and diastolic function of the left ventricle in a group of children with Familial Mediterranean fever. We performed electrocardiography and Doppler echocardiography on patients and controls. Maximum QT, minimum QT, QT dispersion, corrected QT, maximum corrected QT, minimum corrected QT, and corrected QT dispersion intervals were measured from standard 12-lead electrocardiography. No statistically significant differences were found between the groups in QT dispersion, corrected QT dispersion, and systolic–diastolic function of the left ventricle parameters. During the 12 months of follow-up, no ventricular arrhythmias were documented in either group.

scholarly journals DIASTOLIC FUNCTION OF LEFT VENTRICLE IN PATIENTS WITH CORONARY ARTERY DISEASE DURING THE DEVELOPMENT OF ACUTE MYOCARDIAL INFARCTION

2020 ◽  
Vol 20 (2) ◽  
pp. 85-90
Author(s):  
E.V. Sid ◽  
O.V. Soloviov
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Relative Risk ◽  
Left Ventricle ◽  
Diastolic Function ◽  
St Segment Elevation ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment

Acute myocardial infarction is still remaining as one of the most challenging in modern cardiology. Impaired diastolic function of the left ventricle is one of the manifestations of myocardial dysfunction in coronary heart disease and one of the early prognostic criteria. Therefore, the investigation of this group of patients is especially relevant to assess the risk of possible complications and their timely correction. The present study was aimed at evaluating diastolic function of the left ventricle in patients with ischemic heart disease in the development of acute myocardial infarction. Materials and methods. The results of the study are based on a comprehensive survey of 477 patients with coronary heart disease: 280 patients with ST-segment elevation myocardial infarction, 91 individuals with non-ST-segment elevation myocardial infarction and the control group included 76 patients with angina pectoris (II and III functional class, each subgroup of 38 people). All 477 were comparable with regard to age, sex, and social status. Results. The level of DT was significantly higher in the ST-segment elevation myocardial infarction group and when compared to non ST-segment elevation myocardial infarction, 186.50 [173.00-242.00] ms versus 224.00 [182.00-244.00] ms, respectively, (p <0.05). There were similar differences in IVRT values ​​between the groups of patients. The highest relative risk among the patients with ST-segment elevation myocardial infarction was significantly found out in the pseudonormal type, and during the development of Q-Myocardial infarction it was RR = 1.52, 95% CI RR 1,02-2,25. The increase in the relative risk was for the stimulation of the mitral flow during the development of Q-Myocardial infarction and made up RR = 1,31, 95% CI RR 1,11-1,55. Conclusions. 1. The patients with acute myocardial infarction demonstrated impaired diastolic function of the left ventricle, with a predominance of pseudonormal type among the patients with ST-segment elevation myocardial infarction and impaired relaxation in patients with non-ST-segment elevation myocardial infarction. 2. The increase in relative risk among patients with ST-segment elevation myocardial infarction has been well established for the pseudonormal type.

P1483Serial changes in peak left atrial strain predicts diastolic remodelling following percutaneous revascularisation for ST-segment elevation myocardial infarction

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
T Vo ◽  
T Nguyen ◽  
A Chen ◽  
J French ◽  
J Otton ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Diastolic Dysfunction ◽  
Diastolic Function ◽  
Left Atrial ◽  
Prognostic Value ◽  
Left Atrial Strain ◽  
Lower Baseline ◽  
Grade 3 ◽  
The Relationship

Abstract Background Echocardiographic 2D speckle tracking peak left atrial (LA) strain reflects LA reservoir function. Limited studies have reported the relationship between peak LA strain and diastolic dysfunction. In addition, adverse diastolic remodeling (ADR) has been reported, to have better prognostic value than single diastolic function assessment following ST-elevation myocardial infarction (STEMI). Purpose We examined the relationship between serial changes in echocardiographic peak LA strain and diastolic function in STEMI patients. Methods 186 percutaneously revascularized first presentation STEMI patients (87% male, 56.9±10.6 years) underwent serial TTE at baseline (2–7 days) and at follow-up (8–10 weeks) post-STEMI. Peak LA reservoir strain measurements were analysed from apical 2-, 3- and 4- chamber views. Diastolic function was graded as per 2016 guidelines: normal, grade 1, grade 2 and grade 3. ADR was defined as worsening of diastolic function grade (≥1) from baseline to follow-up, or persistent grade 3. Results Lower baseline peak LA strain was associated with grade 2 and grade 3 diastolic dysfunction compared to normal and grade 1 function at follow-up (p<0.05, see figure and table). Change in LA strain was less with worsening grades of diastolic function (see table). ADR was seen in 33 patients. Lower baseline peak LA strain predicted ADR (B=0.86 (0.80–0.92), p<0.0001). In addition, a reduction in peak LA strain at follow up was independently associated with ADR (B=0.91 (0.84–0.97), p=0.007) (see figure). Diastolic function grades with LA strain Follow-up diastolic function Baseline peak LA strain (%) Follow-up peak LA strain (%) Change in peak LA strain (%) Normal (n=91) 35.70±6.38 40.97±8.10 5.26±6.07 Grade 1 (n=61) 30.70±6.97 34.54±8.77 3.84±6.32 Grade 2 (n=17) 23.95±6.11 25.49±5.93 1.54±4.70 Grade 3 (n=17) 23.66±8.07 23.49±10.64 −0.17±7.44 Data presented as mean ± SD. Peak LA strain vs diastolic function Conclusion Peak LA strain is associated with diastolic function following STEMI and differentiates normal diastolic function from diastolic dysfunction. Serial changes in peak LA strain correlated with diastolic remodelling. Longer-term follow-up is required to determine the prognostic value of changes in peak LA strain, and diastolic remodelling.

Abstract 2486: Early Diastolic Mitral Annulus Lengthening Velocity Reflects Coupling between Systolic and Diastolic Function

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Anders Opdahl ◽  
Espen W Remme ◽  
Thomas Helle-Valle ◽  
Trond Vartdal ◽  
Eirik Pettersen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Experimental Study ◽  
Diastolic Function ◽  
Strong Correlation ◽  
Healthy Subjects ◽  
Mitral Annulus ◽  
Volume Loading ◽  
Wide Range ◽  
Systolic And Diastolic Function ◽  
The Relationship

Background: Peak early-diastolic mitral annulus velocity (E’) by tissue Doppler imaging (TDI) has been introduced as a marker of diastolic function. This study investigates mechanisms of E’. Methods: In 7 anesthetized dogs we measured E’ and systolic long-axis shortening (SS) by sonomicrometry and TDI, and the time constant ( tau ) of LV relaxation by micromanometer. In 8 healthy subjects (HS) we measured E’ by TDI and SS by M-mode echo at baseline and during lower body negative pressure (LBNP). We studied 6 patients with myocardial infarction, acutely and after 6 –12 months. Results: In dogs there was a strong correlation between E’ and SS (Fig 1 ), suggesting that E’ is determined primarily by systolic function. However, during ischemia which increased tau (p<<med>0.01) , the relationship between E’ and LV end-diastolic pressure (LVEDP), shifted markedly downwards (Fig 2 ). During volume loading which increased LVEDP (p<0.01), the relationship between E’ and tau shifted markedly upwards (Fig 3 ). Consistent with findings in dogs, healthy subjects demonstrated a strong correlation between E’ and SS during LBNP (Fig 4 ). However, in patients with chronic myocardial infarction the relationship between E’ and systolic shortening was shifted downwards (Fig 4 ). Conclusions: During a wide range of hemodynamic conditions there were strong correlations between E’ and SS. The shifts in the relationships between E’ and LVEDP during ischemia and between E’ and tau during volume loading, indicates that diastolic function modulates E’. These observations indicate a tight coupling between systolic and diastolic function, and challenge the concept that E’ is a specific marker of LV relaxation. Fig 1 Experimental study Fig 2 Experimental study Fig 3 Experimental study Fig 4 Clinical study

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