Immune responses to dietary antigens: oral tolerance

1998 ◽  
Vol 19 (4) ◽  
pp. 173-181 ◽  
Author(s):  
Stephan Strobel ◽  
Allan McI Mowat
Keyword(s):  
Immune Responses ◽  
Oral Tolerance ◽  
Dietary Antigens

scholarly journals Oral Tolerance Induced by Transfer of Food Antigens via Breast Milk of Allergic Mothers Prevents Offspring from Developing Allergic Symptoms in a Mouse Food Allergy Model

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Takeshi Yamamoto ◽  
Yuma Tsubota ◽  
Toshihisa Kodama ◽  
Natsuko Kageyama-Yahara ◽  
Makoto Kadowaki
Keyword(s):  
Food Allergy ◽  
Breast Milk ◽  
Oral Tolerance ◽  
Maternal Exposure ◽  
Oral Intubation ◽  
Female Mice ◽  
Allergic Symptoms ◽  
Dietary Antigens ◽  
Food Antigens

We examined whether maternal exposure to food antigens during lactation and maternal allergic status would affect the development of food allergy in offspring. OVA-sensitized or OVA-nonsensitized BALB/c female mice were exposed or unexposed to OVA during lactation. After weaning, their offspring were systemically sensitized twice with OVA and repeatedly given OVA by oral intubation. While 97.1% of the mice breastfed by OVA-nonsensitized and OVA-unexposed mothers developed allergic diarrhea, 59.7% of the mice breastfed by OVA-exposed nonallergic mothers during lactation and 24.6% of the mice breastfed by OVA-exposed allergic mothers during lactation developed food allergy. Furthermore, OVA was detected in breast-milk from OVA-exposed nonallergic mothers during lactation (4.6±0.5 μg/mL). In addition, OVA-specific IgG1 titers were markedly increased in breast milk from allergic mothers (OVA-sensitized and OVA-unexposed mother:11.0±0.5, OVA-sensitized and OVA-exposed mother:12.3±0.3). Our results suggest that oral tolerance induced by breast milk-mediated transfer of dietary antigens along with their specific immunoglobulins to offspring leads to antigen-specific protection from food allergy.

scholarly journals Toll-Like Receptor 2 as a Regulator of Oral Tolerance in the Gastrointestinal Tract

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Matthew C. Tunis ◽  
Jean S. Marshall
Keyword(s):  
Inflammatory Bowel Disease ◽  
Immune Responses ◽  
Oral Tolerance ◽  
Hygiene Hypothesis ◽  
Complex Relationship ◽  
Toll Like Receptor ◽  
Tlr2 Activation ◽  
Inflammatory Bowel ◽  
Toll Like Receptor 2 ◽  
The Relationship

Food allergy, other adverse immune responses to foods, inflammatory bowel disease, and eosinophilic esophagitis have become increasingly common in the last 30 years. It has been proposed in the “hygiene hypothesis” that dysregulated immune responses to environmental microbial stimuli may modify the balance between tolerance and sensitization in some patients. Of the pattern recognition receptors that respond to microbial signals, toll-like receptors (TLRs) represent the most investigated group. The relationship between allergy and TLR activation is currently at the frontier of immunology research. Although TLR2 is abundant in the mucosal environment, little is known about the complex relationship between bystander TLR2 activation by the commensal microflora and the processing of oral antigens. This review focuses on recent advances in our understanding of the relationship between TLR2 and oral tolerance, with an emphasis on regulatory T cells, eosinophils, B cells, IgA, intestinal regulation, and commensal microbes.

Immune responses to dietary antigens in gluten-sensitive enteropathy of Irish setters

1992 ◽  
Vol 53 (3) ◽  
pp. 293-299 ◽  
Author(s):  
E.J. Hall ◽  
S.D. Carter ◽  
A. Barnes ◽  
R.M. Batt
Keyword(s):  
Immune Responses ◽  
Dietary Antigens ◽  
Gluten Sensitive Enteropathy

Clinical Aspects of Gastrointestinal Food Allergy in Childhood

PEDIATRICS ◽  
2003 ◽  
Vol 111 (Supplement_3) ◽  
pp. 1609-1616 ◽  
Author(s):  
Scott H. Sicherer
Keyword(s):  
Food Allergy ◽  
Immune Responses ◽  
Oral Allergy Syndrome ◽  
Food Allergies ◽  
Rational Approach ◽  
Clinical Aspects ◽  
Dietary Antigens ◽  
Therapeutic Diets ◽  
Gastrointestinal Food Allergy ◽  
Allergic Disorders

Gastrointestinal food allergies are a spectrum of disorders that result from adverse immune responses to dietary antigens. The named disorders include immediate gastrointestinal hypersensitivity (anaphylaxis), oral allergy syndrome, allergic eosinophilic esophagitis, gastritis, and gastroenterocolitis; dietary protein enterocolitis, proctitis, and enteropathy; and celiac disease. Additional disorders sometimes attributed to food allergy include colic, gastroesophageal reflux, and constipation. The pediatrician faces several challenges in dealing with these disorders because diagnosis requires differentiating allergic disorders from many other causes of similar symptoms, and therapy requires identification of causal foods, application of therapeutic diets and/or medications, and monitoring for resolution of these disorders. This review catalogs the spectrum of gastrointestinal food allergies that affect children and provides a framework for a rational approach to diagnosis and management.

scholarly journals Cross-suppression of specific immune responses after oral tolerance

1981 ◽  
Vol 76 (1) ◽  
pp. 83-91 ◽  
Author(s):  
Nelson M. Vaz ◽  
Luiz Carlos Maia ◽  
Donald G. Hanson ◽  
James M. Lynch
Keyword(s):  
Immune Responses ◽  
Oral Tolerance ◽  
Inbred Mice ◽  
Antibody Responses ◽  
Oral Exposure ◽  
Specific Antibodies ◽  
The Cross

Adult normal inbred mice rendered tolerant to OVA by previous oral exposure do not respond to intraperitonela immunization with DNP-OVA in adjuvant. These tolerant mice also form less DNP-specific antibodies to DNP-KLH when immunized with mixtures of DNP-KLH and DNP-OVA, or less HGG-specific antibodies when immunized with cross-linked conjugates of OVA and HGG. These same procedures increased DNP-specific or HGG-specific responses in non-tolerant control mice. The cross-supperssion was ineffective, however, to inhibit already ongoing antibody responses.

Sign in / Sign up

Export Citation Format

Share Document