scholarly journals Alanine Aminotransferase and Risk of the Metabolic Syndrome: A Linear Dose-Response Relationship

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e96068 ◽  
Author(s):  
Setor K. Kunutsor ◽  
Dorothy Seddoh
Keyword(s):  
Metabolic Syndrome ◽  
Dose Response ◽  
Alanine Aminotransferase ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Linear Dose ◽  
The Metabolic Syndrome

scholarly journals Resting heart rate is associated with the risk of metabolic syndrome and its components among Dong adults in southwest China: The China Multi-Ethnic Cohort (CMEC) Study

2021 ◽  
Author(s):  
Xiao Zhang ◽  
Feng Hong ◽  
Zixiu Qin ◽  
Leilei Liu ◽  
Jun Yang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Heart Rate ◽  
Dose Response ◽  
Southwest China ◽  
Positive Association ◽  
Metabolic Risk ◽  
Resting Heart Rate ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Restricted Cubic Splines

Abstract Background High resting heart rate (RHR), one abnormal manifestation of autonomic nervous system, was associated with metabolic disorders. However, the association between RHR and metabolic syndrome (MetS) and its components remains controversial. This study aimed to explore the link between RHR and MetS and its components. Methods The study included 6,589 Dong adults (1,434 patients) from the China Multi-Ethnic Cohort (CMEC) Study. Logistic regression model was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) and assess the association between RHR and MetS, clustered metabolic risk, and MetS components. Restricted cubic splines model was used to evaluate the dose–response relationship between RHR and MetS and its components. Results A positive association existed between RHR and MetS, and people in the highest RHR quartile had a higher MetS risk (OR 1.75 [95% CI 1.42–2.15]) than those in the lowest quartile. The clustered metabolic risk associated with RHR (P < 0.05). Furthermore, RHR was related to elevated blood pressure (BP), elevated triglycerides (TG), and elevated fasting plasma glucose (FPG), the ORs (95% CIs) for the highest versus lowest RHR quartile were 2.06 (1.75–2.43), 1.37 (1.17–1.62), and 2.53 (2.04–3.14), respectively. Similar results were found in sensitivity and subgroup analyses. Also, non-linear dose-response relationship existed between RHR and MetS and elevated levels of BP, TG, and FPG (P < 0.001). Conclusions RHR was related to the risk of MetS and three MetS components (elevated BP, elevated TG, and elevated FPG). RHR may be a useful indicator for MetS.

scholarly journals Vitamin B6, vitamin B12 and methionine and risk of pancreatic cancer: a meta-analysis

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Dan-Hong Wei ◽  
Qi-Qi Mao
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Vitamin B12 ◽  
Dose Response ◽  
Vitamin B6 ◽  
Meta Analysis ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Pancreatic Cancer Risk ◽  
Linear Dose

Abstract Background Nutrients involved in one-carbon metabolism may play a key role in pancreatic carcinogenesis. The aim of this study was to examine the association between pancreatic cancer risk and intake or blood levels of vitamins B6, B12 and methionine via meta-analysis. Methods A systematic search was performed in PubMed, Web of Knowledge and Chinese National Knowledge Infrastructure (CNKI) up to April 2020 to identify relevant studies. Risk estimates and their 95% confidence intervals (CIs) were retrieved from the studies and combined by a random-effect model. Results A total of 18 studies were included in this meta-analysis on the association of vitamin B6, B12 and methionine with pancreatic cancer risk. The combined risk estimate (95% CI) of pancreatic cancer for the highest vs lowest category of vitamin B6 intake and blood pyridoxal 5′-phosphate (PLP, active form of vitamin B6) levels was 0.63 (0.48–0.79) and 0.65 (0.52–0.79), respectively. The results indicated a non-linear dose-response relationship between vitamin B6 intake and pancreatic risk. Linear dose–response relationship was found, and the risk of pancreatic cancer decreased by 9% for every 10 nmol/L increment in blood PLP levels. No significant association were found between pancreatic cancer risk and vitamin B12 intake, blood vitamin B12 levels, methionine intake and blood methionine levels. Conclusion Our study suggests that high intake of vitamin B6 and high concentration of blood PLP levels may be protective against the development of pancreatic cancer. Further research are warranted to confirm the results.

scholarly journals A dose–response meta-analysis reveals an association between vitamin B12 and colorectal cancer risk

2015 ◽  
Vol 19 (8) ◽  
pp. 1446-1456 ◽  
Author(s):  
Nai-Hui Sun ◽  
Xuan-Zhang Huang ◽  
Shuai-Bo Wang ◽  
Yuan Li ◽  
Long-Yi Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dose Response ◽  
Meta Analysis ◽  
Dietary Vitamin ◽  
Vitamin B ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Total Vitamin ◽  
Linear Dose ◽  
Non Linear

AbstractObjectiveThe current meta-analysis evaluated the association between vitamin B12 intake and blood vitamin B12 level and colorectal cancer (CRC) risk.DesignThe PubMed and EMBASE databases were searched. A dose–response analysis was performed with generalized least squares regression, with the relative risk (RR) and 95 % CI as effect values.SettingThe meta-analysis included seventeen studies.SubjectsA total of 10 601 patients.ResultsThe non-linear dose–response relationship between total vitamin B12 intake and CRC risk was insignificant (P=0·690), but the relationship between dietary vitamin B12 intake and CRC risk was significant (P<0·001). Every 4·5 μg/d increment in total and dietary vitamin B12 intake was inversely associated with CRC risk (total intake: RR=0·963; 95 % CI 0·928, 0·999; dietary intake: RR=0·914; 95 % CI 0·856, 0·977). The inverse association between vitamin B12 intake and CRC risk was also significant when vitamin B12 intake was over a dosage threshold, enhancing the non-linear relationship. The non-linear dose–response relationship between blood vitamin B12 level and CRC risk was insignificant (P=0·219). There was an insignificant association between every 150 pmol/l increment in blood vitamin B12 level and CRC risk (RR=1·023; 95 % CI 0·881, 1·187).ConclusionsOur meta-analysis indicates that evidence supports the use of vitamin B12 for cancer prevention, especially among populations with high-dose vitamin B12 intake, and that the association between CRC risk and total vitamin B12 intake is stronger than between CRC risk and dietary vitamin B12 intake only.

The Thermoluminescence Response of Dy Doped Calcium Borate Glass Subjected to 6MV Photon Irradiation

2014 ◽  
Vol 895 ◽  
pp. 390-394 ◽  
Author(s):  
Hamiza Ahmad Tajuddin ◽  
Husin Wagiran ◽  
Rosli Hussin
Keyword(s):  
Dose Response ◽  
Borate Glass ◽  
Glass Sample ◽  
Dopant Concentration ◽  
Response Relationship ◽  
Dose Response Relationship ◽  
Melt Quenching ◽  
Photon Irradiation ◽  
Linear Dose ◽  
Quenching Method

This paper presents the thermoluminescence (TL) response and sensitivity of various dopant concentration of Dy into borate glass. Borates glass present absorption coefficient that closely to human bone and teeth. This fact makes borate as an ideal material for TL material either for medical or environmental dosimeter. Therefore, a series of glasses based on xCaO-(100-x)B2O3system (0 x 100) % weight has been prepared by using melt quenching method. In this research, Dy doped (0.01-0.4) mol% to 30CaO-70B2O3glass sample were studied to investigate the TL properties in terms of dose-response relationship and sensitivity. Samples were irradiated to various doses range 0.5-4.0 Gy subjected to 6 MV photon irradiation by using LINAC Primus MLC 3339. The TL intensity of various dopant concentration were studied and it was founds that the 0.3 mol% Dy has the highest TL response and has linear dose response relationship. The highest sensitivity was calculated as 58 nC.mg-1.Gy-1for 0.3 mol% Dy concentration.

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