148 Harnessing multi-media approaches to support the learning of the lymphatics system in radiation medicine. Phase I: Developing the electronic anatomical images and The accompanying text

2004 ◽  
Vol 72 ◽  
pp. S45
Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
David Z Wang ◽  
Jane H Maksimovic ◽  
Maureen L Mathews ◽  
Wen-Ching Liu

Background: Hypothermia is a known neuronal protecting agent and used in post cardiac arrest. However, its use for stroke and brain trauma has not made any progress due to the lack of accurate way of measuring brain temperature. Hence, hypothermic degree and duration for it to be therapeutic is unknown. The phase I Check Brain Temperature Study was to define regional brain temperatures in normal individuals via MRI thermometry. The established brain temperature map can be used as the baseline to provide therapeutic hypothermia. Method: Temperatures of 5 regions of interest (ROI) of brain (frontal lobe, thalamus, hypothalamus, occipital lobe and cerebellum) were measured in 10 healthy individuals by using proton resonance frequency MRI spectroscopy single voxel method. The scanning protocol include a whole brain anatomical images, (3DFSPGR : TR/TE=150/3.9ms, FOV=24cm,matrix=256x256, slice thickness =1 mm.) and spectroscopy PRESS (TR/TE=1500/144 ms, 8 nex, 2 x 2 x 2 cm^3) on a GE 3T scanner. Ten right handed men (18<age<80) were recruited and their oral and tympanic temperatures were monitored. Average whole head temperature=average of oral temp+tympanic temp and average brain temp=average of temp of 5 regions of interest. Two tails, paired t-test used to compare temps between subjects and ROIs. Results: Average temperature differences between brain (38.2 °C) and head (36.5 °C) is 1.8 °C (p< 0.0000002). Thalamus has the highest temperature among all ROIs in brain. Brain temperature > oral temperature > tympanic temperature. Conclusion: Brain temperatures may not correlate to body temperatures and there is a regional difference. Our finding will be used as the baseline brain temperature map when hypothermia is applied in patients with hemisphere stroke in the phase II study.


2020 ◽  
Vol 29 (4) ◽  
pp. 2109-2130
Author(s):  
Lauren Bislick

Purpose This study continued Phase I investigation of a modified Phonomotor Treatment (PMT) Program on motor planning in two individuals with apraxia of speech (AOS) and aphasia and, with support from prior work, refined Phase I methodology for treatment intensity and duration, a measure of communicative participation, and the use of effect size benchmarks specific to AOS. Method A single-case experimental design with multiple baselines across behaviors and participants was used to examine acquisition, generalization, and maintenance of treatment effects 8–10 weeks posttreatment. Treatment was distributed 3 days a week, and duration of treatment was specific to each participant (criterion based). Experimental stimuli consisted of target sounds or clusters embedded nonwords and real words, specific to each participants' deficit. Results Findings show improved repetition accuracy for targets in trained nonwords, generalization to targets in untrained nonwords and real words, and maintenance of treatment effects at 10 weeks posttreatment for one participant and more variable outcomes for the other participant. Conclusions Results indicate that a modified version of PMT can promote generalization and maintenance of treatment gains for trained speech targets via a multimodal approach emphasizing repeated exposure and practice. While these results are promising, the frequent co-occurrence of AOS and aphasia warrants a treatment that addresses both motor planning and linguistic deficits. Thus, the application of traditional PMT with participant-specific modifications for AOS embedded into the treatment program may be a more effective approach. Future work will continue to examine and maximize improvements in motor planning, while also treating anomia in aphasia.


2007 ◽  
Vol 177 (4S) ◽  
pp. 202-202
Author(s):  
Hirotsugu Uemura ◽  
Motoyoshi Tanaka ◽  
Shigeya Uejima ◽  
Takafumi Minami ◽  
Kiyohide Fujimoto ◽  
...  

2004 ◽  
Vol 171 (4S) ◽  
pp. 72-72 ◽  
Author(s):  
Vincenzo Serretta ◽  
Carlo Pavone ◽  
Antonio Galuffo ◽  
Nino Dispensa ◽  
Marco Vella ◽  
...  
Keyword(s):  

2004 ◽  
Vol 171 (4S) ◽  
pp. 234-234 ◽  
Author(s):  
Harin Padma-Nathan ◽  
Jae Seung Pacik ◽  
Byoung Ok Ahn ◽  
Kyung Koo Kang ◽  
Mi Young Bahng ◽  
...  

2002 ◽  
Vol 110 (2) ◽  
pp. 67-69 ◽  
Author(s):  
F Pröbst
Keyword(s):  

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