scholarly journals PO-0846: The impact of anatomical changes on the accumulated carbon ion dose in pancreatic cancer patients

2016 ◽  
Vol 119 ◽  
pp. S402-S403
Author(s):  
A.C. Houweling ◽  
K. Fukata ◽  
Y. Kubota ◽  
H. Shimada ◽  
C.R.N. Rasch ◽  
...  
2016 ◽  
Vol 119 (2) ◽  
pp. 319-325 ◽  
Author(s):  
Antonetta C. Houweling ◽  
Kyohei Fukata ◽  
Yoshiki Kubota ◽  
Hirofumi Shimada ◽  
Coen R.N. Rasch ◽  
...  

2017 ◽  
Vol 62 (8) ◽  
pp. 3051-3064 ◽  
Author(s):  
Antonetta C Houweling ◽  
Koen Crama ◽  
Jorrit Visser ◽  
Kyohei Fukata ◽  
Coen R N Rasch ◽  
...  

2021 ◽  
Vol 38 (2) ◽  
pp. 158-165
Author(s):  
Ilaria Pergolini ◽  
I. Ekin Demir ◽  
Christian Stöss ◽  
Klaus Emmanuel ◽  
Robert Rosenberg ◽  
...  

Background: This survey aimed to register changes determined by the COVID-19 pandemic on pancreatic surgery in a specific geographic area (Germany, Austria, and Switzerland) to evaluate the impact of the pandemic and obtain interesting cues for the future. Methods: An online survey was designed using Google Forms focusing on the local impact of the pandemic on pancreatic surgery. The survey was conducted at 2 different time points, during and after the lockdown. Results: Twenty-five respondents (25/56) completed the survey. Many aspects of oncological care have been affected with restrictions and delays: staging, tumor board, treatment selection, postoperative course, adjuvant treatments, outpatient care, and follow-up. Overall, 60% of respondents have prioritized pancreatic cancer patients according to stage, age, and comorbidities, and 40% opted not to operate high-risk patients. However, for 96% of participants, the standards of care were guaranteed. Discussion/Conclusions: The first wave of the COVID-19 pandemic had an important impact on pancreatic cancer surgery in central Europe. Guidelines for prompt interventions and prevention of the spread of viral infections in the surgical environment are needed to avoid a deterioration of care in cancer patients in the event of a second wave or a new pandemic. High-volume centers for pancreatic surgery should be preferred and their activity maintained. Virtual conferences have proven to be efficient during this pandemic and should be implemented in the near future.


In Vivo ◽  
2021 ◽  
Vol 35 (2) ◽  
pp. 1307-1311
Author(s):  
NICOLAE BACALBASA ◽  
CAMELIA DIACONU ◽  
CORNEL SAVU ◽  
CARMEN SAVU ◽  
OVIDIU STIRU ◽  
...  

2020 ◽  
Vol 31 ◽  
pp. S139
Author(s):  
M. Bensi ◽  
B. Di Stefano ◽  
M. Chiaravalli ◽  
M. Ribelli ◽  
A. Spring ◽  
...  

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Xiaomeng Zhang ◽  
Ningyi Ma ◽  
Weiqiang Yao ◽  
Shuo Li ◽  
Zhigang Ren

Abstract Background The DNA damage and repair pathway is considered a promising target for developing strategies against cancer. RAD51, also known as RECA, is a recombinase that performs the critical step in homologous recombination. RAD51 has recently received considerable attention due to its function in tumor progression and its decisive role in tumor resistance to chemotherapy. However, its role in pancreatic cancer has seldom been investigated. In this report, we provide evidence that RAD51, regulated by KRAS, promotes pancreatic cancer cell proliferation. Furthermore, RAD51 regulated aerobic glycolysis by targeting hypoxia inducible factor 1α (HIF1α). Methods TCGA (The Cancer Genome Atlas) dataset analysis was used to examine the impact of RAD51 expression on overall survival of pancreatic cancer patients. Lentivirus-mediated transduction was used to silence RAD51 and KRAS expression. Quantitative real-time PCR and western blot analysis validated the efficacy of the knockdown effect. Analysis of the glycolysis process in pancreatic cancer cells was also performed. Cell proliferation was determined using a CCK-8 (Cell Counting Kit-8) proliferation assay. Results Pancreatic cancer patients with higher levels of RAD51 exhibited worse survival. In pancreatic cancer cells, RAD51 positively regulated cell proliferation, decreased intracellular reactive oxygen species (ROS) production and increased the HIF1α protein level. KRAS/MEK/ERK activation increased RAD51 expression. In addition, RAD51 was a positive regulator of aerobic glycolysis. Conclusion The present study reveals novel roles for RAD51 in pancreatic cancer that are associated with overall survival prediction, possibly through a mechanism involving regulation of aerobic glycolysis. These findings may provide new predictive and treatment targets for pancreatic cancer.


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