Poly(ethylene oxide)-modified poly(β-amino ester) nanoparticles as a pH-sensitive biodegradable system for paclitaxel delivery

2003 ◽  
Vol 86 (2-3) ◽  
pp. 223-234 ◽  
Author(s):  
Anupama Potineni ◽  
David M Lynn ◽  
Robert Langer ◽  
Mansoor M Amiji
Keyword(s):  
Ethylene Oxide ◽  
Ph Sensitive ◽  
Amino Ester ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Micellization of pH-sensitive poly(butadiene)-block -poly(2 vinylpyridine)-block -poly(ethylene oxide) triblock copolymers: Complex formation with anionic surfactants

2017 ◽  
Vol 134 (38) ◽  
pp. 45313 ◽  
Author(s):  
Leonard Ionut Atanase ◽  
Jean-Philippe Lerch ◽  
Simona Caprarescu ◽  
Camelia Elena Iurciuc Tincu ◽  
Gerard Riess
Keyword(s):  
Complex Formation ◽  
Ethylene Oxide ◽  
Anionic Surfactants ◽  
Triblock Copolymers ◽  
Ph Sensitive ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

scholarly journals Drug Delivery System Based on pH-Sensitive Biocompatible Poly(2-vinyl pyridine)-b-poly(ethylene oxide) Nanomicelles Loaded with Curcumin and 5-Fluorouracil

Polymers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1450 ◽  
Author(s):  
Camelia-Elena Iurciuc-Tincu ◽  
Monica Stamate Cretan ◽  
Violeta Purcar ◽  
Marcel Popa ◽  
Oana Maria Daraba ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Ethylene Oxide ◽  
Ph Sensitive ◽  
Hydrophobic Drugs ◽  
Practical Utilization ◽  
Vinyl Pyridine ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Smart polymeric micelles (PMs) are of practical interest as nanocarriers for the encapsulation and controlled release of hydrophobic drugs. Two hydrophobic drugs, naturally-based curcumin (Cur) and synthetic 5-fluorouracil (5-FU), were loaded into the PMs formed by a well-defined pH-sensitive poly(2-vinyl pyridine)-b-poly(ethylene oxide) (P2VP90-b-PEO398) block copolymer. The influence of the drug loading on the micellar sizes was investigated by dynamic light scattering (DLS) and it appears that the size of the PMs increases from around 60 to 100 nm when Cur is loaded. On the contrary, the loading of the 5-FU has a smaller effect on the micellar sizes. This difference can be attributed to higher molar mass of Cur with respect to 5-FU but also to higher loading efficiency of Cur, 6.4%, compared to that of 5-FU, 5.8%. In vitro drug release was studied at pH 2, 6.8, and 7.4, and it was observed that the pH controls the release of both drugs. At pH 2, where the P2VP sequences from the “frozen-in” micellar core are protonated, the drug release efficiencies exceed 90%. Moreover, it was demonstrated, by in vitro assays, that these PMs are hemocompatible and biocompatible. Furthermore, the PMs protect the Cur against the photo-degradation, whereas the non-ionic PEO corona limits the adsorption of bovine serum albumin (BSA) protein on the surface. This study demonstrates that these pH-sensitive PMs are suitable for practical utilization as human-safe and smart, injectable drug delivery systems.

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