Actions of the novel oral antidiabetic agent HQL-975 in insulin-resistant non-insulin-dependent diabetes mellitus model animals

1998 ◽  
Vol 41 (2) ◽  
pp. 101-111 ◽  
Author(s):  
Yuji Ishikawa ◽  
Masahiko Nagumo Isao Saito ◽  
Tomoyuki Ikemoto ◽  
Hidekazu Takeno ◽  
Kazubiro Watanabe ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
The Novel ◽  
Antidiabetic Agent ◽  
Oral Antidiabetic Agent ◽  
Insulin Resistant ◽  
Oral Antidiabetic ◽  
Insulin Dependent

Receptor-mediated endocytosis of insulin: inhibition of [125I]iodoinsulin internalization in insulin resistant diabetic states of man

1989 ◽  
Vol 121 (4) ◽  
pp. 581-586 ◽  
Author(s):  
George Grunberger ◽  
Dominique Geiger ◽  
Jean-Louis Carpentier ◽  
Alec Robert ◽  
Phillip Gorden
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Electron Microscopic ◽  
Electron Microscopic Autoradiography ◽  
Receptor Mediated Endocytosis ◽  
Insulin Resistant ◽  
Patients With Diabetes ◽  
Insulin Dependent

Abstract. We have used electron microscopic autoradiography to quantitatively study receptor-mediated endocytosis of [125I] insulin in freshly isolated monocytes from patients with non-insulin-dependent diabetes mellitus. In obese, non-obese, and lipoatrophic patients with diabetes, internalization of [125I] insulin was impaired at 30 min of incubation at 37°C. By 60 min of incubation, however, internalization was indistinguishable from that of normals. In obese non-diabetic controls, internalization at 30 min was slightly less than internalization in normals but greater than that of the diabetic group. Dieting was associated with normalization of internalization in the obese group. We conclude that the rate of [125I]insulin insulin internalization is impaired in non-insulin-dependent diabetes and compare this to previously reported results in insulin-dependent diabetes mellitus.

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