Receptor-mediated endocytosis of insulin: inhibition of [125I]iodoinsulin internalization in insulin resistant diabetic states of man

1989 ◽  
Vol 121 (4) ◽  
pp. 581-586 ◽  
Author(s):  
George Grunberger ◽  
Dominique Geiger ◽  
Jean-Louis Carpentier ◽  
Alec Robert ◽  
Phillip Gorden
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Electron Microscopic ◽  
Electron Microscopic Autoradiography ◽  
Receptor Mediated Endocytosis ◽  
Insulin Resistant ◽  
Patients With Diabetes ◽  
Insulin Dependent

Abstract. We have used electron microscopic autoradiography to quantitatively study receptor-mediated endocytosis of [125I] insulin in freshly isolated monocytes from patients with non-insulin-dependent diabetes mellitus. In obese, non-obese, and lipoatrophic patients with diabetes, internalization of [125I] insulin was impaired at 30 min of incubation at 37°C. By 60 min of incubation, however, internalization was indistinguishable from that of normals. In obese non-diabetic controls, internalization at 30 min was slightly less than internalization in normals but greater than that of the diabetic group. Dieting was associated with normalization of internalization in the obese group. We conclude that the rate of [125I]insulin insulin internalization is impaired in non-insulin-dependent diabetes and compare this to previously reported results in insulin-dependent diabetes mellitus.

scholarly journals Induction and maintenance of remission of insulin-dependent diabetes mellitus in repeated courses of hyperbaric oxygenation

1999 ◽  
Vol 45 (4) ◽  
pp. 10-13
Author(s):  
A. V. Dreval ◽  
V. A. Gubkina ◽  
S. O. Kiselev ◽  
R. S. Tishenin ◽  
G. S. Molchanov ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Hyperbaric Oxygenation ◽  
Insulin Dependent Diabetes Mellitus ◽  
Diabetes Remission ◽  
Diabetes Duration ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Patients With Diabetes ◽  
Insulin Dependent

The efficacy of hyperbaric oxygenation (HBO) is studied in diabetics with newly detected or lasting for less than 1 year disease. The possibility of inducing and/or prolonging diabetes remission by HBO and the efficacy of repeated courses of HBO are evaluated. Fifty-three patients with insulin-dependent diabetes mellitus (IDDM) (28 men and 25 women) aged 15-39 years, suffering from the disease for up to 12 month without apparent complications, were administered intensive insulin therapy with human insulin preparations and 10-day HBO courses. HBO courses repeated every 4 months promoted compensation of carbohydrate metabolism by stimulating residual insulin secretion in patients with IDDM lasting for up to one year, the effect of HBO progressively decreasing with each course. Manifest positive effect of HBO persisted for 2 months. After the first course of HBO, remission of IDDM ensued in 41.5% cases. Patients aged over 25 years with intact insulin secretion on an empty stomach were more disposed to remission. Remissions were equally incident in patients with diabetes duration of up to 6 months and in those with diabetes duration of 6-12 months. A history of ketoacidotic coma episodes does not rule out the induction of a remission.

scholarly journals Gender Differences in Diabetes Attitudes and Adherence

1995 ◽  
Vol 21 (6) ◽  
pp. 523-529 ◽  
Author(s):  
James T. Fitzgerald ◽  
Robert M. Anderson ◽  
Wayne K. Davis
Keyword(s):  
Diabetes Mellitus ◽  
Gender Differences ◽  
Health Professionals ◽  
Self Care ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Men And Women ◽  
Patients With Diabetes ◽  
Insulin Dependent

This study focused on three questions: Is there a difference in men's and women's diabetes attitudes? Do health professionals give different recommendations to men and women? Is there a difference between men and women in care adherence? A total of 1201 patients with diabetes were surveyed; 65% of these patients were women. Differences in diabetes attitudes (three of seven attiticdes) were most evident between men and women with insulin-dependent diabetes mellitus (IDDM). No differences were found in the attitudes of men and women with non-insulin-dependent diabetes mellitus (NIDDM) using insulin, and only one attitude was different for patients with NIDDM not using insulin. Few differences were observed in the recommendations given by health professionals to men and women. Gender differences in adherence to the components of self-care also were minimal. These findings may indicate that there are many similarities in the reactions of men and women who have been diagnosed with diabetes.

scholarly journals Epidemiology of diabetes mellitus

1995 ◽  
Vol 41 (3) ◽  
pp. 44-46
Author(s):  
V. I. Pankiv
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Epidemiological Studies ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Industrialized Countries ◽  
State Register ◽  
Number Of Patients ◽  
Patients With Diabetes ◽  
Insulin Dependent

Diabetes mellitus (DM) is one of the most common diseases, the frequency of which is steadily increasing every year. In industrialized countries, the prevalence of DM is 4-5%. Despite the large number of existing forms of diabetes associated with various syndromes and diseases, the main ones are two that are characterized as spontaneous: insulin-dependent diabetes mellitus (IDDM) and non-insulin-dependent diabetes (NIDDM). Statistical data on the prevalence of the disease are based on the registration of a medical diagnosis of diabetes and in general reflect mainly the prevalence of spontaneous forms of IDDM and NIDDM. In 1991, 1 826 758 patients with DM were registered in the Russian Federation, of which 295 333 (16.2%) suffered from IDDM. Compared with 1990, the number of patients with diabetes increased by 5.78%. However, the figures do not reflect the actual prevalence of diabetes. The conducted epidemiological studies on the frequency of diabetes show that the true number of patients with diabetes is 3-4 times higher compared to the registered one. These include people with a mild form of NIDDM who do not need medical treatment, as well as people with impaired glucose tolerance. In these groups, disorders of carbohydrate metabolism occur in a subclinical form, and the recorded prevalence of diabetes is largely determined by the quality of the medical examination. A more accurate picture of the prevalence of various types of diabetes can be obtained only with the State Register for diabetes, its development is necessary in the near future.

scholarly journals Reproductive function in women with insulin-dependent diabetes mellitus

1994 ◽  
Vol 40 (1) ◽  
pp. 52-56
Author(s):  
L S Matveyeva ◽  
A A Berdyklycheva ◽  
O D Strekolshikova
Keyword(s):  
Diabetes Mellitus ◽  
Reproductive Function ◽  
Insulin Dependent Diabetes Mellitus ◽  
Reproductive Age ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Reproductive Disorders ◽  
Pregnancy And Childbirth ◽  
Patients With Diabetes ◽  
Insulin Dependent

In recent years, there has been increasing scientific interest in studying reproductive disorders in patients with diabetes mellitus (DM), which is associated with advances in the treatment of the disease, which can significantly increase the life expectancy of patients with diabetes, maximally delay the onset and progression of severe complications of the disease, as well as that the risk of insulin-dependent diabetes mellitus (IDDM) in the offspring was much lower than previously thought. A fairly high frequency of menstrual irregularities, infertility, an increase in the pathology of pregnancy and childbirth, and a significant reduction in the fertility period in women with diabetes mellitus are noted in the literature. Similar violations are found, according to literature 1'01. In ’/ 3 sick women. Amenorrhea in women of reproductive age is observed 2 times more often than in the population. Spontaneous abortions were noted 1.3 times more often, the birth rate in patients with diabetes is 1.59, while normally it is 1.89.

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