P-952 Expression and immunogenicity of Cancer/testis tumor associated antigens in NSCLC

This review will focus on recent knowledge related to circulating autoantibodies (AAbs) to tumor-associated antigens (TAAs) in epithelial ovarian carcinoma. So far, the following TAAs have been identified to elicit circulating AAbs in epithelial ovarian carcinoma: p53, homeobox proteins (HOXA7, HOXB7), heat shock proteins (HSP-27, HSP-90), cathepsin D, cancer-testis antigens (NY-ESO-1/LAGE-1), MUC1, GIPC-1, IL-8, Ep-CAM, and S100A7. Since AAbs to TAAs have been identified in the circulation of patients with early-stage cancer, it has been speculated that the assessment of a panel of AAbs specific for epithelial ovarian carcinoma TAAs might hold great potential as a novel tool for early diagnosis of epithelial ovarian carcinoma.

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Tumor-Associated Antigens

JAMA ◽

10.1001/jama.1973.03220020040013 ◽

1973 ◽

Vol 223 (2) ◽

pp. 174 ◽

Cited By ~ 1

Author(s):

Stanley E. Order

Keyword(s):

Tumor Associated Antigens

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Identification of Widely Applicable Tumor-Associated Antigens for Breast Cancer Immunotherapy

10.21236/ada588103 ◽

2006 ◽

Author(s):

Jining Bai

Keyword(s):

Breast Cancer ◽

Cancer Immunotherapy ◽

Tumor Associated Antigens

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Paternity in men with stage I testis tumors on surveillance.

Journal of Clinical Oncology ◽

10.1200/jco.1998.16.2.733 ◽

1998 ◽

Vol 16 (2) ◽

pp. 733-734 ◽

Cited By ~ 30

Author(s):

H W Herr ◽

N Bar-Chama ◽

M O'Sullivan ◽

P C Sogani

Keyword(s):

Clinical Stage ◽

Germ Cell Tumors ◽

Stage I ◽

Retroperitoneal Lymph Node Dissection ◽

Nerve Sparing ◽

Testis Tumor ◽

Fertility Potential ◽

Testis Tumors ◽

Nonseminomatous Germ Cell Tumors

PURPOSE We report long-term paternity in men with stage I testis tumors who were managed initially by surveillance. PATIENTS AND METHODS One hundred five patients with clinical stage I nonseminomatous germ cell tumors of the testis were entered on a surveillance protocol and followed up for more than 10 years. Actual fertility potential was assessed by pregnancy. RESULTS Of the 105 patients, 41 (39%) have fathered children, which includes 36 of 78 (46%) patients while on active surveillance and five of 27 (19%) patients after treatment for relapse. Of 63 couples who attempted a pregnancy on surveillance or were presumed capable of impregnation (whether they tried or not), 41 (65%) were successful. CONCLUSION These results show that the majority of men with stage I testis tumor who are on surveillance after orchiectomy, have a suitable partner, and attempt impregnation achieve a successful pregnancy. Pregnancy rates appear to be less than reported in men who have a nerve-sparing retroperitoneal lymph node dissection (RPLND) because more patients on surveillance require treatment for relapse, which reduces their chances for pregnancy.

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Serum autoantibodies against a panel of 15 tumor-associated antigens in the detection of ovarian cancer

Tumor Biology ◽

10.1177/1010428317699132 ◽

2017 ◽

Vol 39 (6) ◽

pp. 101042831769913 ◽

Cited By ~ 7

Author(s):

Hao Sun ◽

Jian-Xiang Shi ◽

Hong-Fei Zhang ◽

Meng-Tao Xing ◽

Pei Li ◽

...

Keyword(s):

Ovarian Cancer ◽

Tumor Associated Antigens

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Expression of Cancer Testis Antigens in Tumor-Adjacent Normal Liver Is Associated with Post-Resection Recurrence of Hepatocellular Carcinoma

Cancers ◽

10.3390/cancers13102499 ◽

2021 ◽

Vol 13 (10) ◽

pp. 2499

Author(s):

Lisanne Noordam ◽

Zhouhong Ge ◽

Hadiye Özturk ◽

Michail Doukas ◽

Shanta Mancham ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Normal Liver ◽

Occult Metastasis ◽

Recurrence Rates ◽

Curative Intent ◽

Cancer Testis Antigens ◽

Negative Prognostic Factor ◽

Increased Risk ◽

Hcc Recurrence ◽

Cancer Testis

High recurrence rates after resection of hepatocellular carcinoma (HCC) with curative intent impair clinical outcomes of HCC. Cancer/testis antigens (CTAs) are suitable targets for cancer immunotherapy if selectively expressed in tumor cells. The aims were to identify CTAs that are frequently and selectively expressed in HCC-tumors, and to investigate whether CTAs could serve as biomarkers for occult metastasis. Tumor and paired tumor-free liver (TFL) tissues of HCC-patients and healthy tissues were assessed for mRNA expression of 49 CTAs by RT-qPCR and protein expression of five CTAs by immunohistochemistry. Twelve CTA-mRNAs were expressed in ≥10% of HCC-tumors and not in healthy tissues except testis. In tumors, mRNA and protein of ≥ 1 CTA was expressed in 78% and 71% of HCC-patients, respectively. In TFL, CTA mRNA and protein was found in 45% and 30% of HCC-patients, respectively. Interestingly, CTA-expression in TFL was an independent negative prognostic factor for post-resection HCC-recurrence and survival. We established a panel of 12 testis-restricted CTAs expressed in tumors of most HCC-patients. The increased risk of HCC-recurrence in patients with CTA expression in TFL, suggests that CTA-expressing (pre-)malignant cells may be a source of HCC-recurrence, reflecting the relevance of targeting these to prevent HCC-recurrence.

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