Estimating the social and economic benefits of pharmaceutical innovation: modeling clinical trial results in hiv disease

Author(s):  
Kit Simpson ◽  
Eberhard Voit ◽  
Russell Goodman ◽  
Elinor Chumney
2016 ◽  
Vol 47 (S 01) ◽  
Author(s):  
U. Schara ◽  
C. McDonald ◽  
K. Bushby ◽  
M. Tulinius ◽  
R. Finkel ◽  
...  

Author(s):  
Subha Sankar Paul ◽  
Goutam Biswas

: COVID-19 is a public health emergency of international concern. Although, considerable knowledge has been acquired with time about the viral mechanism of infection and mode of replication, yet no specific drugs or vaccines have been discovered against SARS-CoV-2, till date. There are few small molecule antiviral drugs like Remdesivir and Favipiravir which have shown promising results in different advanced stage of clinical trials. Chloroquinine, Hydroxychloroquine, and Lopinavir-Ritonavir combination, although initially was hypothesized to be effective against SARS-CoV-2, are now discontinued from the solidarity clinical trials. This review provides a brief description of their chemical syntheses along with their mode of action and clinical trial results available in Google and different peer reviewed journals till 24th October 2020.


SAGE Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 215824402110163
Author(s):  
Tariq H. Malik ◽  
Chunhui Huo

Result disclosure of clinical trial posts a conflicting logic between private secrecy and public interest. Despite ethical and legal requirements for disclosing clinical trial results, clinical trials’ sponsors tend to withhold the results. We explored the location, timing, and rationale behind the withheld clinical trial results. Based on the entrepreneurial orientation (EO) perspective, we propose that organizational EO contingencies moderate the disclosure decision. We used the completed clinical trial projects in China by foreign and domestic sponsors. First, we found that a unit increase in the sponsor’s experience can increase the disclosure about 1.01 times. Second, we found that industrial enterprises disclose results about 3.7 times more than universities do. Third, we found that foreign clinical trial projects in China tend to disclose 3.9 times more than domestic projects. We link these findings to two types of audience. First, we inform the academic community on the theory and empirics regarding risk-taking behavior in the biopharmaceutical industry’s clinical trial activity. Second, we address the general audiences concerned about the ethical and socioeconomic wellbeing of the public.


2002 ◽  
Vol 62 (3) ◽  
pp. 1026-1033 ◽  
Author(s):  
Steve J. Schwab ◽  
Mark A. Weiss ◽  
Fred Rushton ◽  
John P. Ross ◽  
Jerry Jackson ◽  
...  

Land ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 57
Author(s):  
Fernando Allende Álvarez ◽  
Gillian Gómez-Mediavilla ◽  
Nieves López-Estébanez ◽  
Pedro Molina Holgado ◽  
Judith Ares Barajas

The present paper highlights the importance of hedgerows and enclosures in the mountains of Central Spain. Now, these landscapes have suffered profound variations in terms of agroforestry practices, especially in the Mediterranean mountains where the characteristic multifunctional has largely been lost. The article analyzes land uses changes, dynamics, and their morphological features between the first half of the 20th Century (1956) and the second decade of the present time (2019). The paper was divided into three sections. First, the identification of land uses using orthophotograph and aerial photograph; after that the info was checked with fieldwork. Eleven categories were identified according to the dominant use and land use changes and size of land parcels were taken into consideration. Second, the configuration and the information collected through the type and intensity of change in land uses made it possible to recognise and quantify their distribution and trend between these two dates. Also, the kernel density algorithm available in the Arcgis 10.5 software was used to obtain density and changes in land parcels. Finally, an overview is given of the main role that this agroforestry plays due to the social, ecological, and economic benefits that they provide for allowing sustainable development.


2014 ◽  
Vol 151 (1_suppl) ◽  
pp. P83-P84 ◽  
Author(s):  
Jonathan Kil ◽  
Eric D. Lynch ◽  
Scott Griffiths ◽  
Edward Lobarinas ◽  
Christopher Spankovich ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document