Basaloid squamous carcinoma: A clinical comparison of two histologic types with poorly differentiated squamous cell carcinoma

1998 ◽  
Vol 119 (5) ◽  
pp. 471-475 ◽  
Author(s):  
Sandra M. Winzenburg ◽  
Gloria A. Niehans ◽  
George Evan ◽  
Daly Kathleen ◽  
George L. Adams
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Squamous Carcinoma ◽  
Basaloid Squamous Carcinoma ◽  
Clinical Comparison ◽  
Poorly Differentiated ◽  
Histologic Types ◽  
Basaloid Squamous

Basaloid-Squamous Carcinomas of the Upper Aerodigestive Tracts

1989 ◽  
Vol 98 (11) ◽  
pp. 919-920 ◽  
Author(s):  
John G. Batsakis ◽  
Adel El Naggar
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Squamous Carcinoma ◽  
High Grade ◽  
Basaloid Squamous Carcinoma ◽  
Base Of Tongue ◽  
Supraglottic Larynx ◽  
Basaloid Squamous

Basaloid-squamous carcinoma is a new addition to the lexicon of variants of squamous cell carcinoma. The carcinoma is distinctive histologically, is biologically high grade, and manifests a predilection for the base of tongue, hypopharynx, and supraglottic larynx.

scholarly journals Clinicopathologic Characteristics and Clinical Outcomes of Esophageal Basaloid Squamous Carcinoma: Experience at a Single Institution

10.9738/cc195 ◽  
2013 ◽  
Vol 98 (4) ◽  
pp. 450-454 ◽  
Author(s):  
Youichi Kumagai ◽  
Koji Nagata ◽  
Toru Ishiguro ◽  
Norihiro Haga ◽  
Kohki Kuwabara ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Clinical Outcomes ◽  
Squamous Cell ◽  
Squamous Carcinoma ◽  
Venous Invasion ◽  
Clinicopathologic Characteristics ◽  
Pathologic Stage ◽  
Basaloid Squamous Carcinoma ◽  
Basaloid Squamous

Abstract This retrospective study investigated the clinicopathologic characteristics and clinical outcomes of esophageal basaloid squamous carcinoma (BSC). Among 190 patients with esophageal carcinoma treated surgically between 1998 and 2011, we identified 9 (4.7%) with BSC. All of the patients were male, with a median age of 65 years. The frequencies of venous invasion, lymphatic invasion, and lymph node metastasis were 56%, 89%, and 67%, respectively. A total of 2 patients were pathologic stage 1, 5 were stage 2, and 2 were stage 3. Tumor recurrence was observed in 56% of the patients. The 5-year survival rate for patients with esophageal BSC was 40%, which was compatible with the figure of 53.8% for control patients (n = 18) with typical squamous cell carcinoma matched for sex, age, tumor location, and pathologic stage (P = 0.45). Although esophageal BSC shows aggressive lymph-vascular invasion and has a high likelihood of recurrence, its prognosis seems identical to that of typical squamous cell carcinoma.

Expression of PCNA, p53, Bax, and Bcl-X in oral poorly differentiated and basaloid squamous cell carcinoma: Relationships with prognosis

Head & Neck ◽  
2005 ◽  
Vol 27 (11) ◽  
pp. 982-989 ◽  
Author(s):  
Fernanda C. G. Sampaio-Góes ◽  
Denise T. Oliveira ◽  
Regina G. Dorta ◽  
Suely Nonogaki ◽  
Gilles Landman ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basaloid Squamous Cell Carcinoma ◽  
Poorly Differentiated ◽  
Basaloid Squamous

scholarly journals Prognostic Implications of ALDH1 and Notch1 in Different Subtypes of Oral Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Silas Antonio Juvencio de Freitas Filho ◽  
Cláudia Malheiros Coutinho-Camillo ◽  
Katia Klug Oliveira ◽  
Bárbara Beltrame Bettim ◽  
Clóvis Antônio Lopes Pinto ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Basaloid Squamous Cell Carcinoma ◽  
Poorly Differentiated ◽  
Basaloid Squamous

Background. The present study aimed to investigate the clinical significance and prognostic value of the immunoexpression of cancer stem cell markers, ALDH1 and Notch1, in subtypes of oral squamous cell carcinoma. Materials and Methods. The expression of ALDH1 and Notch1 in 63 patients with well and poorly differentiated oral squamous cell carcinomas and their subtypes, verrucous carcinoma and basaloid squamous cell carcinoma, was evaluated by immunohistochemistry. The semi-quantitative analysis of the ALDH1 and Notch immunoexpression levels, based on the capture of 10 microscopic fields, at 400X magnification, at the invasive tumor front was performed and associated with clinicopathological variables using the chi-square test or Fisher’s exact test. The overall and disease-free survival rates were estimated according to the Kaplan–Meier method and the curves were compared using the log-rank test. The independent effects of variables were calculated using Cox’s proportional hazards regression model. Results. Strong ALDH1 and Notch1 expression was observed in 16 (25.4%) and 27 (42.9%) oral squamous cell carcinomas including their subtypes, respectively. Most tumors with strong immunoexpression of ALDH1 were basaloid squamous cell carcinoma (56.3%). Statistically significant associations were observed between the strong immunoexpression of Notch1 in poorly differentiated oral squamous cell carcinoma with perineural infiltration ( p  = 0.011) and lymph node involvement (pN+) ( p  = 0.034). The strong immunoexpression of ALDH1 was a prognostic factor associated with worse overall survival ( p  = 0.040) for patients with oral cancer. Conclusion. The strong immunoexpression of Notch1 can contribute to identification of patients with poorly differentiated oral squamous cell carcinoma, who have perineural infiltration or lymph node metastasis. In addition, the strong immunoexpression of ALDH1 may help to identify a worse prognosis in patients with oral squamous cell carcinoma and their subtypes.

Basaloid Squamous Cell Carcinoma of the Head and Neck: Clinicopathological Features and Differential Diagnosis

1996 ◽  
Vol 105 (1) ◽  
pp. 75-82 ◽  
Author(s):  
Leon Barnes ◽  
Christina MacMillan ◽  
Alfio Ferlito ◽  
Alessandra Rinaldo ◽  
Giuseppe Altavilla ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Squamous Carcinoma ◽  
Basaloid Squamous Cell Carcinoma ◽  
Small Cell Neuroendocrine Carcinoma ◽  
Basal Cell Adenocarcinoma ◽  
Carcinoma Squamous Cell ◽  
Basaloid Squamous

Basaloid squamous cell carcinoma is a recently recognized variant of squamous cell carcinoma. The lesion is histologically distinctive and manifests a predilection for the supraglottis, pyriform sinus, and tongue base. The immunohistochemical profile is discussed. The differential diagnoses include adenoid cystic carcinoma, small cell neuroendocrine carcinoma, basal cell adenocarcinoma, adenosquamous carcinoma, squamous cell carcinoma, spindle cell squamous carcinoma, mucoepidermoid carcinoma, and adenoid squamous cell carcinoma. Basaloid squamous cell carcinoma is a biologically high-grade tumor with a propensity for nodal as well as systemic metastases. It is a morphologic and phenotypic entity with a separate prognostic significance.

scholarly journals Cutaneous squamous cell carcinoma arising in hidradenitis suppurativa: A case report

2019 ◽  
Vol 7 ◽  
pp. 2050313X1984735 ◽  
Author(s):  
Catherine F Roy ◽  
Simon F Roy ◽  
Feras M Ghazawi ◽  
Erica Patocskai ◽  
Annie Bélisle ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hidradenitis Suppurativa ◽  
Rare Complication ◽  
Excisional Biopsy ◽  
Necrosis Factor Alpha ◽  
Spindle Cells ◽  
Poorly Differentiated ◽  
Well Differentiated

We present a case of a 64-year-old man who presented with a rapidly growing tumor in the left buttock and intergluteal cleft area, which was affected by hidradenitis suppurativa. The patient was on tumor necrosis factor-alpha inhibitors for hidradenitis suppurativa for 2 years prior to the development of the mass. Initial biopsy of the mass showed a well-differentiated squamous cell carcinoma with spindle cells and positive epithelial immunomarkers. Subsequent excisional biopsy of the tumor showed an infiltrating poorly differentiated squamous cell carcinoma composed of islands of atypical sarcomatoid spindle cells. Squamous cell carcinoma arising in hidradenitis suppurativa is a rare complication which may occur secondary to chronic inflammation and epidermal hyperproliferation in hidradenitis suppurativa–affected areas.

scholarly journals Pulmonary metastasectomy for esophageal basaloid squamous cell carcinoma component at 66 months after esophagectomy

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Kumiko Sekiguchi ◽  
Takeshi Matsutani ◽  
Tsutomu Nomura ◽  
Nobutoshi Hagiwara ◽  
Akihisa Matsuda ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Pulmonary Metastasectomy ◽  
Basaloid Squamous Cell Carcinoma ◽  
Basaloid Squamous
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