P2797 Growth hormone induces myocardial expression of creatine transporter and decreases plasma levels of II-1beta in rats during early post-infarct cardiac remodelling

2003 ◽  
Vol 24 (5) ◽  
pp. 526
Author(s):  
E OMEROVIC
Keyword(s):  
Growth Hormone ◽  
Plasma Levels ◽  
Cardiac Remodelling ◽  
Creatine Transporter

Growth hormone induces myocardial expression of creatine transporter and decreases plasma levels of IL-1β in rats during early postinfarct cardiac remodeling

2003 ◽  
Vol 13 (5) ◽  
pp. 239-245 ◽  
Author(s):  
Elmir Omerovic ◽  
Entela Bollano ◽  
Malin Lorentzon ◽  
Marion Walser ◽  
Lillemor Mattsson-Hultén ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Cardiac Remodeling ◽  
Plasma Levels ◽  
Creatine Transporter

DOSE REGIMENS OF HUMAN GROWTH HORMONE: EFFECTS OF CONTINUOUS INFUSION AND OF A GELATIN VEHICLE ON GROWTH IN RATS AND RATE OF ABSORPTION IN RABBITS

1980 ◽  
Vol 87 (2) ◽  
pp. 303-312 ◽  
Author(s):  
P. MARY COTES ◽  
W. A. BARTLETT ◽  
ROSE E. GAINES DAS ◽  
P. FLECKNELL ◽  
R. TERMEER
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Plasma Levels ◽  
Time Course ◽  
Human Growth ◽  
Daily Injection ◽  
Glycine Buffer ◽  
Hormone Effects ◽  
Rate Of Absorption ◽  
Hypophysectomized Rats

Different methods for administration of human growth hormone (hGH) have been examined with a view to efficient use of the limited amounts of hGH at present available for clinical use. We found that in hypophysectomized rats (1) hGH administered by continuous subcutaneous infusion induced a greater increase in body weight (referred to throughout as growth) than hGH administered by intermittent (daily) injection and (2) intermittent injections of hGH dissolved in 16% gelatin induced more growth than hGH dissolved in a glycine buffer. It was further found that (1) hGH dissolved in 16% gelatin compared with hGH dissolved in a glycine buffer induced lower maximal levels of immunoreactive plasma hGH and between 7 and 9 h after treatment higher plasma levels when injected subcutaneously in rabbits, (2) 125I-labelled hGH added as a tracer to hGH in gelatin was removed more slowly from subcutaneous injection sites in rabbits than 125I-labelled hGH given with hGH in glycine buffer and (3) changes in the ratio of hGH to gelatin had little effect on the time-course of plasma levels of hGH in the rabbit. Addition of the protease inhibitors aprotinin or 6-aminohexanoic acid, to injection of hGH in gelatin or glycine did not induce any consistent increase in plasma levels of hGH.

PLASMA LEVELS OF GROWTH HORMONE IN PATIENTS WITH DIABETES MELLITUS, HYPERCHOLESTEROLAEMIA AND LIVER DISEASES

1959 ◽  
Vol XXXII (IV) ◽  
pp. 480-490 ◽  
Author(s):  
Olof Forsman ◽  
Carl A. Gemzell
Keyword(s):  
Diabetes Mellitus ◽  
Growth Hormone ◽  
Plasma Level ◽  
Human Growth Hormone ◽  
Plasma Levels ◽  
Liver Diseases ◽  
Human Growth ◽  
Diabetic Patients ◽  
Elevated Plasma ◽  
Patients With Diabetes

ABSTRACT From the plasma of 30 out of 51 patients with various metabolic disorders a »growth-hormone-like« factor was concentrated which when injected into hypophysectomized rats increased the width of the tibial epiphysis. A similar factor had previously been concentrated from the plasma of acromegalic patients. It was tentatively concluded that this factor was identical with human growth hormone (HGH). Diabetes mellitus. Of 40 patients with diabetes mellitus 24 showed elevated plasma levels of human growth hormone (HGH). The frequency of elevated plasma levels was higher in young diabetics than in older diabetic patients; in many cases a nondiabetic complication was associated with an elevated level. In the plasma of 4 patients with diabetes mellitus and liver diseases an elevated plasma level of HGH was found while in 3 patients with Kimmelstiel-Wilson's syndrome no increase of HGH was found. Liver diseases. In the plasma of 4 patients with various liver diseases an elevated plasma level of HGH was found while in the plasma of another 4 patients no increase of HGH was found. Hypercholesterolaemia. In the plasma of 2 patients with familiar hypercholesterolaemia elevated levels of HGH was found while no HGH was found in a patient with an idiopathic type of the disease.

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