PLASMA LEVELS OF GROWTH HORMONE IN PATIENTS WITH DIABETES MELLITUS, HYPERCHOLESTEROLAEMIA AND LIVER DISEASES

1959 ◽  
Vol XXXII (IV) ◽  
pp. 480-490 ◽  
Author(s):  
Olof Forsman ◽  
Carl A. Gemzell
Keyword(s):  
Diabetes Mellitus ◽  
Growth Hormone ◽  
Plasma Level ◽  
Human Growth Hormone ◽  
Plasma Levels ◽  
Liver Diseases ◽  
Human Growth ◽  
Diabetic Patients ◽  
Elevated Plasma ◽  
Patients With Diabetes

ABSTRACT From the plasma of 30 out of 51 patients with various metabolic disorders a »growth-hormone-like« factor was concentrated which when injected into hypophysectomized rats increased the width of the tibial epiphysis. A similar factor had previously been concentrated from the plasma of acromegalic patients. It was tentatively concluded that this factor was identical with human growth hormone (HGH). Diabetes mellitus. Of 40 patients with diabetes mellitus 24 showed elevated plasma levels of human growth hormone (HGH). The frequency of elevated plasma levels was higher in young diabetics than in older diabetic patients; in many cases a nondiabetic complication was associated with an elevated level. In the plasma of 4 patients with diabetes mellitus and liver diseases an elevated plasma level of HGH was found while in 3 patients with Kimmelstiel-Wilson's syndrome no increase of HGH was found. Liver diseases. In the plasma of 4 patients with various liver diseases an elevated plasma level of HGH was found while in the plasma of another 4 patients no increase of HGH was found. Hypercholesterolaemia. In the plasma of 2 patients with familiar hypercholesterolaemia elevated levels of HGH was found while no HGH was found in a patient with an idiopathic type of the disease.

DOSE REGIMENS OF HUMAN GROWTH HORMONE: EFFECTS OF CONTINUOUS INFUSION AND OF A GELATIN VEHICLE ON GROWTH IN RATS AND RATE OF ABSORPTION IN RABBITS

1980 ◽  
Vol 87 (2) ◽  
pp. 303-312 ◽  
Author(s):  
P. MARY COTES ◽  
W. A. BARTLETT ◽  
ROSE E. GAINES DAS ◽  
P. FLECKNELL ◽  
R. TERMEER
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Plasma Levels ◽  
Time Course ◽  
Human Growth ◽  
Daily Injection ◽  
Glycine Buffer ◽  
Hormone Effects ◽  
Rate Of Absorption ◽  
Hypophysectomized Rats

Different methods for administration of human growth hormone (hGH) have been examined with a view to efficient use of the limited amounts of hGH at present available for clinical use. We found that in hypophysectomized rats (1) hGH administered by continuous subcutaneous infusion induced a greater increase in body weight (referred to throughout as growth) than hGH administered by intermittent (daily) injection and (2) intermittent injections of hGH dissolved in 16% gelatin induced more growth than hGH dissolved in a glycine buffer. It was further found that (1) hGH dissolved in 16% gelatin compared with hGH dissolved in a glycine buffer induced lower maximal levels of immunoreactive plasma hGH and between 7 and 9 h after treatment higher plasma levels when injected subcutaneously in rabbits, (2) 125I-labelled hGH added as a tracer to hGH in gelatin was removed more slowly from subcutaneous injection sites in rabbits than 125I-labelled hGH given with hGH in glycine buffer and (3) changes in the ratio of hGH to gelatin had little effect on the time-course of plasma levels of hGH in the rabbit. Addition of the protease inhibitors aprotinin or 6-aminohexanoic acid, to injection of hGH in gelatin or glycine did not induce any consistent increase in plasma levels of hGH.

Clinical investigation of human growth hormone (H.G.H.) in the human bile and serum on liver diseases

1973 ◽  
Vol 8 (1) ◽  
pp. 64-64
Author(s):  
H. Kawakami ◽  
A. Maruhashi ◽  
T. Kunimasa ◽  
M. Yamashita ◽  
A. Miyoshi
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Liver Diseases ◽  
Clinical Investigation ◽  
Human Growth ◽  
Human Bile

HYPOPITUITARISM AND DIABETES MELLITUS: EFFECT OF HUMAN GROWTH HORMONE

PEDIATRICS ◽  
1968 ◽  
Vol 41 (5) ◽  
pp. 905-916
Author(s):  
Maurice D. Kogut ◽  
George N. Donnell ◽  
Shun M. Ling ◽  
S. Douglas Frasier
Keyword(s):  
Diabetes Mellitus ◽  
Growth Hormone ◽  
Human Growth Hormone ◽  
Glucose Homeostasis ◽  
Human Growth ◽  
Immunoreactive Insulin ◽  
Oral Glucose ◽  
Pituitary Insufficiency ◽  
Family History Of Diabetes ◽  
Altered Glucose

Although hypoglycemia and insulin sensitivity are characteristic of hypopituitarism, the association of hypoglycemia, diabetes mellitus, and pituitary insufficiency has not been previously described in a child. Studies in a 44-month-old male with these features and observations following human growth hormone administration are reported. The patient weighed 7 lb, 9 oz at birth and was 20 in. long, but he did not grow or gain weight as expected. There was a strong family history of diabetes mellitus. At age 17 months hypoglycemic seizures occured (blood glucose < 5 mg/100 ml). An oral glucose tolerance test was abnormal. Subsequently, hyperglycemia and glycosuria, but not ketonuria, occured. Serum immunoreactive insulin following intravenous tolbutamide rose, suggesting endogenous insulin production. The treatment of diabetes mellitus with insulin was extremely difficult because of marked sensitivity, suggesting an additional cause for altered glucose homeostasis. Endocrine studies (PBI, I131 uptake before and after TSH, 24-hour urines for 17-ketosteroids and 17-ketogenic steroids following metopirone and ACTH, and immunoassays of serum growth hormone following intravenous administration of insulin and L-arginine) indicated lack of normal activity of thyrotropin, ACTH, and growth hormone. Human growth hormone, 1.0 mg. daily, resulted in a growth of 5½ in. and a weight gain of 11 lb in 8 months. There were no further episodes of hypoglycemia which facilitated control of the diabetes with insulin. These observations have demonstrated the importance of HGH in glucose homeostasis and that HGH is not necessary for the development of diabetes mellitus.

EFFECT OF CORTICOTROPHIN ON PLASMA LEVELS OF HUMAN GROWTH HORMONE

The Lancet ◽  
1969 ◽  
Vol 294 (7633) ◽  
pp. 1278-1280 ◽  
Author(s):  
GastonR. Zahnd ◽  
André Nadeau ◽  
Karl-E. Von Mühlendahl
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Plasma Levels ◽  
Human Growth
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