Cortisol Enhances non-REM Sleep and Growth Hormone Secretion in Elderly Subjects

1997 ◽  
Vol 18 (4) ◽  
pp. 423-429 ◽  
Author(s):  
S Bohlhalter ◽  
H Murck ◽  
F Holsboer ◽  
A Steiger

1991 ◽  
Vol 124 (5) ◽  
pp. 516-520 ◽  
Author(s):  
Gian Paolo Ceda ◽  
Graziano Ceresini ◽  
Licia Denti ◽  
Dario Magnani ◽  
Lorenzo Marchini ◽  
...  

Abstract. The basal and GH-releasing hormone-stimulated secretion of GH declines in the elderly. We tested the ability of cytidine 5'-diphosphocholine, a drug used in the treatment of stroke and Parkinson's disease, to alter GH secretion in 11 healthy elderly volunteers, aged 69-84. Each subject received an iv infusion of 2 g of cytidine 5'-diphosphocholine or normal saline. GHRH and TRH were also administered during cytidine 5'diphosphocholine infusions. The infusion of cytidine 5'-diphosphocholine induced a 4-fold (p<0.05) increase in serum GH levels over basal values. A small increase in GH was seen after GHRH administration. However, the addition of GHRH to the cytidine 5'-diphosphocholine infusion resulted in a GH response which was significantly greater than that seen after GHRH alone; the integrated concentration of GH was more than 2-fold greater in the cytidine 5'-diphosphocholine treated group (706.85± 185.1 vs 248.9±61.4 μg · l−1 · (120 min)−1; p=0.01). The PRL and TSH responses to TRH were not significantly affected by cytidine 5'-diphosphocholine infusion, indicating that dopaminergic mechanisms are not involved. These studies demonstrate that cytidine 5'-diphosphocholine can enhance basal and GHRH-stimulated GH release in the elderly, but the mechanism of action of the drug remains unclear.





1974 ◽  
Vol 77 (1_Suppl) ◽  
pp. S6 ◽  
Author(s):  
S. Raptis ◽  
H. Hirth-Schmidt ◽  
K. E. Schröder ◽  
E. F. Pfeiffer


2018 ◽  
Author(s):  
Alexey Kalinin ◽  
Natalia Strebkova ◽  
Olga Zheludkova ◽  
Maria Kareva






1988 ◽  
Vol 263 (20) ◽  
pp. 9682-9685
Author(s):  
R W Holl ◽  
M O Thorner ◽  
G L Mandell ◽  
J A Sullivan ◽  
Y N Sinha ◽  
...  




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