Safety and immunogenicity of varying dosages of trivalent inactivated influenza vaccine administered by needle-free jet injectors

Vaccine ◽  
2001 ◽  
Vol 19 (32) ◽  
pp. 4703-4709 ◽  
Author(s):  
Lisa A. Jackson ◽  
Glenn Austin ◽  
Robert T. Chen ◽  
Richard Stout ◽  
Frank DeStefano ◽  
...  
2017 ◽  
Vol 11 (1) ◽  
Author(s):  
Prachya Mukda ◽  
Kulachate Pianthong ◽  
Wirapan Seehanam

Currently, most of commercial needle-free jet injectors generate the liquid jet by a method called “driving object method” (DOM); however, the reliability and efficiency are still questioned. This paper proposes a new concept of jet generation method, known as “impact driven method” (IDM). A prototype of an IDM jet injector is designed, built, tested, and compared to a commercial device (Cool.click, Tigard, OR). Fundamental characteristics, i.e., the exit jet velocity and impact pressure, are measured. Jet injection processes are visualized both in air and in 20% polyacrylamide by high speed photography. In this study, from the prototype of the IDM jet injector, a maximum jet velocity of 400 m/s and impact peak pressure of 68 MPa can be obtained. It is clear that the IDM jet injector provides a double pulsed liquid jet, which is a major advantage over the commercial jet injector. Because, the first pulse gives a shorter erosion stage, and then, immediately the second pulse follows and provides a better penetration, wider lateral dispersion, and considerably less back splash. Hence, lower pain level and higher delivery efficiency should be achieved. It can be concluded that the IDM concept is highly feasible for implementation in real applications, either for human or animal injection. However, the control and accuracy of IDM still needs to be carefully investigated.


The Lancet ◽  
2014 ◽  
Vol 384 (9944) ◽  
pp. 674-681 ◽  
Author(s):  
Linda McAllister ◽  
Jonathan Anderson ◽  
Kristen Werth ◽  
Iksung Cho ◽  
Karen Copeland ◽  
...  

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Yunfei Wang ◽  
Long Yue ◽  
Lechuan Hu ◽  
Jing Wang

In order to study the injection and diffusion process of the drug in the subcutaneous tissue of a needle-free jet injectors (NFJIs) in detail and understand the influence of different nozzle geometry on the diffusion process of the drug, in this paper, numerical simulations were performed to study the diffusion process of the drug in the subcutaneous tissue of NFJIs with cylindrical nozzle. On this basis, the differences of the drug diffusion process with different nozzle geometries were analyzed. The results show that the drug diffused in the shape of ellipsoid in the subcutaneous tissue. The penetration of the drug into the subcutaneous tissue is deeper under the condition of conical nozzle and conical cylindrical nozzle at the same time. However, it takes longer to spread to the interface between skin and subcutaneous tissue in reverse.


2011 ◽  
Vol 5 (1) ◽  
Author(s):  
Brian D. Hemond ◽  
Andrew Taberner ◽  
Cathy Hogan ◽  
Bryan Crane ◽  
Ian W. Hunter

A jet injector platform technology that provides improved performance over existing jet injectors through the use of a controllable linear Lorentz-force actuator and software-based control system has been developed. Injectors designed on this platform are capable of delivering injections using arbitrary pressure pulse shaping. Pulse shaping has been shown to allow a wide degree of control over the depth to which the injection is delivered. A software-based injector control system improves repeatability and allows for automatic reloading of the injector, a task that would be difficult to implement using existing jet injector platforms. A design for a prototype autoloading controllable jet injector (cJI) based on this platform is detailed. The injection capability of this cJI was evaluated both in-vitro and in-vivo using a tissue analog, excised porcine tissue, and ovine tissue. An analysis of the cJI’s performance indicates that this design is capable of delivering a controllable volume of fluid to a controllable depth based entirely on the parameter’s input into the control software.


2019 ◽  
Vol 53 ◽  
pp. 101167 ◽  
Author(s):  
Pankaj Rohilla ◽  
Yatish S. Rane ◽  
Idera Lawal ◽  
Andrew Le Blanc ◽  
Justin Davis ◽  
...  

Author(s):  
Michele Schlich ◽  
Rosita Primavera ◽  
Francesco Lai ◽  
Chiara Sinico ◽  
Paolo Decuzzi

Author(s):  
M. A. Listvan ◽  
R. P. Andres

Knowledge of the function and structure of small metal clusters is one goal of research in catalysis. One important experimental parameter is cluster size. Ideally, one would like to produce metal clusters of regulated size in order to characterize size-dependent cluster properties.A source has been developed which is capable of producing microscopic metal clusters of controllable size (in the range 5-500 atoms) This source, the Multiple Expansion Cluster Source, with a Free Jet Deceleration Filter (MECS/FJDF) operates as follows. The bulk metal is heated in an oven to give controlled concentrations of monomer and dimer which were expanded sonically. These metal species were quenched and condensed in He and filtered to produce areosol particles of a controlled size as verified by mass spectrometer measurements. The clusters were caught on pre-mounted, clean carbon films. The grids were then transferred in air for microscopic examination. MECS/FJDF was used to produce two different sizes of silver clusters for this study: nominally Ag6 and Ag50.


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