Associated malformations in infants with cleft lip and palate: A prospective, population-based study

1998 ◽  
Vol 56 (4) ◽  
pp. 527
Author(s):  
Roger E Alexander
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Population Based ◽  
Population Based Study ◽  
Associated Malformations

scholarly journals School performance for children with cleft lip and palate: a population-based study

2016 ◽  
Vol 43 (2) ◽  
pp. 222-231 ◽  
Author(s):  
J. C. Bell ◽  
C. Raynes-Greenow ◽  
R. Turner ◽  
C. Bower ◽  
A. Dodson ◽  
...  
Keyword(s):  
School Performance ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Population Based ◽  
Population Based Study

Population-Based Study on the Practice of Breastfeeding in Children Born with Cleft Lip and Palate

2005 ◽  
Vol 42 (6) ◽  
pp. 687-693 ◽  
Author(s):  
Letícia W. Garcez ◽  
Elsa R. J. Giugliani
Keyword(s):  
Cleft Palate ◽  
Median Duration ◽  
Exclusive Breastfeeding ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Population Based ◽  
Breastfeeding Duration ◽  
Porto Alegre ◽  
Initiation Rate ◽  
Population Based Study

Objective To investigate the practice of breastfeeding and related difficulties in children born in Porto Alegre, Brazil, with cleft lip, cleft palate, and cleft lip with cleft palate. Design Cohort, observational, and population-based study. Population and Sample Mothers of all children born in 2001 and 2002 with cleft lip and palate in the city of Porto Alegre, Brazil (n = 31), were interviewed in their homes. From the information collected, the frequencies of breastfeeding and exclusive breastfeeding in the first year of life were estimated and the median duration was computed according to the type of cleft. A descriptive analysis was used to study the difficulties. Main Indicators Initiation rate, pattern, duration, and difficulties of breastfeeding and exclusive breastfeeding. Results The initiation rate of breastfeeding was 100% and its median duration was 42.5 days. Exclusive breastfeeding was initiated by 67.7% of the sample and maintained for 15 days (median). The breastfeeding duration was significantly higher in the presence of cleft lip, being equal or even superior to (in the case of exclusive breastfeeding) the median of Porto Alegre's general population. The most frequently mentioned difficulties were weak suction, difficulty attaching to the breast, and breast milk escaping through the nostrils. Conclusions In spite of the diverse difficulties reported and the lack of professional support after discharge from the maternity wards, the initiation rate and the duration of breastfeeding of children with cleft lip and palate found in this study reinforce the theory that this malformation, especially cleft lip, is compatible with successful breastfeeding.

scholarly journals Effect of Cleft Lip With or Without Palate on Pediatric General and Dental Growth in Korea: a Nationwide Population-based Cohort Study

2021 ◽  
Author(s):  
Jeong Yeop Ryu ◽  
Tae Hyun Park ◽  
Joon Seok Lee ◽  
Jung Dug Yang ◽  
Ho Yun Chung ◽  
...  
Keyword(s):  
Head Circumference ◽  
Cleft Lip ◽  
Primary Teeth ◽  
Cleft Lip And Palate ◽  
Dental Treatment ◽  
Population Based ◽  
Population Based Study ◽  
The Status ◽  
Dental Screening ◽  
Lower Height

Abstract There are very few nationwide studies discussing the height, weight, head circumference, and dental screening of children with cleft lip with or without palate (CL/P), with most reports on this subject based on a 1900s cohort. This study aimed to characterize CL/P children in the 2000s in terms of height, weight, head circumference, and dental screening. This nationwide population-based study evaluated the National Health Insurance Service-Infants and Children’s Health Screening (NHIS-INCHS), specifically the height, weight, and head circumference of millions of children. Dental screening data, including the status of each tooth and comprehensive dental judgment, were also evaluated. Syndromic and nonsyndromic CL/P children had lower height, weight, and head circumference than no CL/P children until the age of 66–71 months. Children with cleft palate only or both cleft lip and palate showed similar results. Regarding dental screening, the primary teeth of CL/P children erupted later and fell out faster than no CL/P children. Dental caries was also more common in CL/P children. Children with CL/P had inferior general growth, regardless of palatoplasty surgery. More aggressive dental treatment was required for CL/P children due to the instability of primary teeth and tendency for caries.

scholarly journals A nationwide cohort study on growth impairment by cleft lip with or without palate

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jeong Yeop Ryu ◽  
Tae Hyun Park ◽  
Joon Seok Lee ◽  
Jung Dug Yang ◽  
Ho Yun Chung ◽  
...  
Keyword(s):  
Head Circumference ◽  
Cleft Lip ◽  
Primary Teeth ◽  
Cleft Lip And Palate ◽  
Dental Treatment ◽  
Population Based ◽  
Population Based Study ◽  
The Status ◽  
Dental Screening ◽  
Lower Height

AbstractThere are very few nationwide studies discussing the height, weight, head circumference, and dental screening of children with cleft lip with or without palate (CL/P), with most reports on this subject based on a 1900s cohort. This study aimed to characterize CL/P children in the 2000s in terms of height, weight, head circumference, and dental screening. This nationwide population-based study evaluated the National Health Insurance Service-Infants and Children’s Health Screening (NHIS-INCHS), specifically the height, weight, and head circumference of millions of children. Dental screening data, including the status of each tooth and comprehensive dental judgment, were also evaluated. Syndromic and nonsyndromic CL/P children had lower height, weight, and head circumference than no CL/P children until the age of 66–71 months. Children with cleft palate only or both cleft lip and palate showed similar results. Regarding dental screening, the primary teeth of CL/P children erupted later and fell out faster than no CL/P children. Dental caries was also more common in CL/P children. Children with CL/P had inferior general growth, regardless of palatoplasty surgery. More aggressive dental treatment was required for CL/P children due to the instability of primary teeth and tendency for caries.

Unmet Burden of Cleft Lip and Palate in Rural Gujarat, India: A Population-Based Study

2014 ◽  
Vol 39 (1) ◽  
pp. 41-46 ◽  
Author(s):  
Monty U. Khajanchi ◽  
Hemant Shah ◽  
Purvi Thakkar ◽  
Martin Gerdin ◽  
Nobhojit Roy
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Population Based ◽  
Population Based Study

scholarly journals Case–Parent Trio Studies in Cleft Lip and Palate

2020 ◽  
Vol 07 (03) ◽  
pp. 075-079
Author(s):  
Mahamad Irfanulla Khan ◽  
Prashanth CS
Keyword(s):  
Genetic Variants ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Association Studies ◽  
Geographical Location ◽  
Genetic Association Studies ◽  
Population Based ◽  
Genome Wide Association Studies ◽  
Family Based ◽  
Study Designs

AbstractCleft lip with or without cleft palate (CL/P) is one of the most common congenital malformations in humans involving various genetic and environmental risk factors. The prevalence of CL/P varies according to geographical location, ethnicity, race, gender, and socioeconomic status, affecting approximately 1 in 800 live births worldwide. Genetic studies aim to understand the mechanisms contributory to a phenotype by measuring the association between genetic variants and also between genetic variants and phenotype population. Genome-wide association studies are standard tools used to discover genetic loci related to a trait of interest. Genetic association studies are generally divided into two main design types: population-based studies and family-based studies. The epidemiological population-based studies comprise unrelated individuals that directly compare the frequency of genetic variants between (usually independent) cases and controls. The alternative to population-based studies (case–control designs) includes various family-based study designs that comprise related individuals. An example of such a study is a case–parent trio design study, which is commonly employed in genetics to identify the variants underlying complex human disease where transmission of alleles from parents to offspring is studied. This article describes the fundamentals of case–parent trio study, trio design and its significances, statistical methods, and limitations of the trio studies.

Academic Achievement in Individuals with Cleft: A Population-Based Register Study

2012 ◽  
Vol 49 (2) ◽  
pp. 153-159 ◽  
Author(s):  
Martin Persson ◽  
Magnus Becker ◽  
Henry Svensson
Keyword(s):  
Academic Achievement ◽  
General Population ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Population Based ◽  
Study Data ◽  
Control Group ◽  
High Grade ◽  
Compulsory School ◽  
Grade Point

Objective The focus of this study was to determine whether there were any significant differences in academic achievement between students with a cleft and the general population of Swedish students at the typical time of graduation from compulsory school (usually 16 years of age). Design A retrospective population-based study. Data were obtained from the Swedish Medical Birth Register for the years 1973 through 1986 and were linked to the Swedish School–Grade Register. Participants A total of 511 individuals with cleft palate (CP), 651 individuals with cleft lip (CL), and 830 individuals with cleft lip and palate (CLP) were compared with a control group consisting of 1,249,404 individuals. Main Outcome Measures (1) Not receiving school leaving certificate; (2) odds of receiving lowest grade and reduced odds of receiving a high grade in the following subjects: (a) Mathematics, (b) English, (c) Swedish, (d) Physical Education, and (e) grade point average (GPA). Results The group with cleft had higher odds of not receiving leaving certificates in comparison with the general population. They also had higher odds of receiving the lowest grade and/or reduced odds of receiving a high grade in the subjects analyzed together, with strong evidence of lower GPA in comparison with the general population. Individuals with CP were affected the most, followed by individuals with CLP; least affected were individuals with CL. Conclusion This study clearly indicates that adolescents with cleft lip and/or palate in Sweden experience significant deficits in their educational achievements in compulsory school.

scholarly journals Association of other congenital anomalies in children with cleft lip and palate: a prospective hospital based observational study

2019 ◽  
Vol 6 (3) ◽  
pp. 1059
Author(s):  
Padmasani Venkat Ramanan ◽  
Rajesh Balan ◽  
Jyotsna Murthy ◽  
Syed Altaf Hussain
Keyword(s):  
Congenital Anomaly ◽  
Congenital Anomalies ◽  
Congenital Malformations ◽  
Congenital Heart ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Associated Anomalies ◽  
Live Births ◽  
Associated Malformations ◽  
Syndrome Association

Background: Cleft lip and palate is a common congenital anomaly affecting approximately 1 in 700 live births in south Asia. It is often associated with syndromes and other malformations but the exact incidence of these in Asians is not known. The present study was carried out to determine the association of other congenital anomalies in children with cleft.Methods: The study was carried out in the patients attending the Cleft centre of our Hospital. They were examined for other major external congenital malformations and syndrome association.  Where ever relevant, appropriate investigations were done.Results: Of the total of 2367 children examined, 262 (11.06%) had congenital malformations.  Among the non-syndromic children, 9% had associated malformations.  The commonest was congenital heart disease (1.4%) following by genitourinary and skeletal anomalies.  The highest number of anomalies was seen in patients with cleft palate alone (24.89%). 1.4% patients had identifiable syndromes.Conclusions: The study emphasizes the need for a thorough examination of all children with cleft.  The overall lower incidence of syndromic clefts and associated anomalies in present study suggests that other etiological factors may be involved in our country.

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