Rectal Cancer Trial Supports Preoperative Radiation

2006 ◽  
Vol 36 (17) ◽  
pp. 47
Author(s):  
TIMOTHY F. KIRN
Keyword(s):  
Rectal Cancer ◽  
Preoperative Radiation ◽  
Cancer Trial

Adverse Effects of Preoperative Radiation Therapy for Rectal Cancer: Long-Term Follow-Up of the Swedish Rectal Cancer Trial

2005 ◽  
Vol 23 (34) ◽  
pp. 8697-8705 ◽  
Author(s):  
Helgi Birgisson ◽  
Lars Påhlman ◽  
Ulf Gunnarsson ◽  
Bengt Glimelius
Keyword(s):  
Rectal Cancer ◽  
Radiation Therapy ◽  
Adverse Effects ◽  
Bowel Obstruction ◽  
Primary Treatment ◽  
Preoperative Irradiation ◽  
Preoperative Radiation ◽  
Cancer Trial ◽  
Preoperative Radiation Therapy ◽  
Increased Risk

Purpose To analyze the occurrence of subacute and late adverse effects in patients treated with preoperative irradiation for rectal cancer. Patients and Methods The study population included 1,147 patients randomly assigned to preoperative radiation therapy or surgery alone in the Swedish Rectal Cancer Trial conducted 1987 through 1990. Patient data were matched against the Swedish Hospital Discharge Register to identify patients admitted to hospital after the primary treatment of the rectal cancer. Patients with known residual disease were excluded, and patients with a recurrence were censored 3 months before the date of recurrence. Relative risks (RR) with 95% CIs were calculated. Results Irradiated patients were at increased risk of admissions during the first 6 months from the primary treatment (RR = 1.64; 95% CI, 1.21 to 2.22); these were mainly for gastrointestinal diagnoses. Overall, the two groups showed no difference in the risk of admissions more than 6 months from the primary treatment (RR = 0.95; 95% CI, 0.80 to 1.12). Regarding specific diagnoses, however, RRs were increased for admissions later than 6 months from the primary treatment in irradiated patients for unspecified infections, bowel obstruction, abdominal pain, and nausea. Conclusion Gastrointestinal disorders, resulting in hospital admissions, seem to be the most common adverse effect of short-course preoperative radiation therapy in patients with rectal cancer. Bowel obstruction was the diagnosis of potentially greatest importance, which was more frequent in irradiated than in nonirradiated patients.

Improved Survival with Preoperative Radiotherapy in Resectable Rectal Cancer

2017 ◽  
Author(s):  
Arielle C. Dubose ◽  
Benjamin D. Lee ◽  
SreyRam Kuy
Keyword(s):  
Rectal Cancer ◽  
Radiation Therapy ◽  
Clinical Case ◽  
Preoperative Radiotherapy ◽  
Distant Recurrence ◽  
Preoperative Radiation ◽  
Cancer Trial ◽  
Resectable Rectal Cancer ◽  
Study Intervention

The landmark Swedish Rectal Cancer Trial examined whether preoperative radiation given to patients <80 years of age with resectable rectal cancer impacted rate of local recurrence and survival compared with immediate surgical resection. This trial demonstrated that neoadjuvant radiation therapy decreased rates of local and distant recurrence and improved survival. This chapter describes the basics of the study, including funding, year study began, year study was published, study location, who was studied, who was excluded, how many patients, study design, study intervention, follow-up, endpoints, results, and criticism and limitations. The chapter briefly reviews other relevant studies and information, gives a summary and discusses implications, and concludes with a relevant clinical case.

scholarly journals Robotic colorectal surgery: more than a fantastic toy?

2018 ◽  
Vol 3 (1) ◽  
pp. 65-68 ◽  
Author(s):  
James W.T. Toh ◽  
Kevin Phan ◽  
Seon-Hahn Kim
Keyword(s):  
Rectal Cancer ◽  
Colorectal Surgery ◽  
Da Vinci Surgical System ◽  
Current Evidence ◽  
Rectal Cancer Surgery ◽  
Cancer Trial ◽  
Robotic Colorectal Surgery ◽  
Significant Difference ◽  
Meta Analyses ◽  
Laparoscopic Assisted

AbstractThere has been a rapid rise in the number of robotic colorectal procedures worldwide since the da Vinci Surgical System robotic technology was approved for surgical procedures in the year 2000. Several recent meta-analyses and systematic reviews have shown a significant difference in outcomes between robotic and laparoscopic rectal cancer surgery. However, these results from pooled data have not been supported by the initial results reported from the Robotic assisted versus laparoscopic assisted resection for rectal cancer trial. In this article, we examine the current evidence for robotic colorectal surgery, assess its features and functionality, evaluate its learning curve and provide our perspective on its future.

Down-staging in rectal cancer by preoperative radiation therapy

1998 ◽  
Vol 42 (1) ◽  
pp. 282
Author(s):  
O.W.M. Meijer ◽  
R.J.F. Felt-Bersma ◽  
S. Meijer ◽  
M.A. Cuesta ◽  
B.J. Slotman
Keyword(s):  
Rectal Cancer ◽  
Radiation Therapy ◽  
Preoperative Radiation ◽  
Preoperative Radiation Therapy
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