Stochastic determination of the chromosomal region responsible for expression of human glial fibrillary acidic protein in astrocytic tumors

1998 ◽  
Vol 247 (1) ◽  
pp. 29-32 ◽  
Author(s):  
Toshiki Yoshimine ◽  
Motohiko Maruno ◽  
Eiji Kumura ◽  
A.K.M Ghulam Muhammad ◽  
Hirotomo Ninomiya ◽  
...  
1978 ◽  
Vol 35 (1) ◽  
pp. 147-155 ◽  
Author(s):  
C.M. Jacque ◽  
C. Vinner ◽  
M. Kujas ◽  
M. Raoul ◽  
J. Racadot ◽  
...  

1992 ◽  
Vol 108 (2) ◽  
pp. 148-161 ◽  
Author(s):  
Page A. Erickson ◽  
Stuart C. Feinstein ◽  
Geoffrey P. Lewis ◽  
Steven K. Fisher

2006 ◽  
Vol 366 (1-2) ◽  
pp. 336-340 ◽  
Author(s):  
Joost L.M. Vissers ◽  
Marsha E.C. Mersch ◽  
Chris F. Rosmalen ◽  
Marijke J.M.T. van Heumen ◽  
Wieneke J.A. van Geel ◽  
...  

Stroke ◽  
1991 ◽  
Vol 22 (10) ◽  
pp. 1254-1258 ◽  
Author(s):  
A Aurell ◽  
L E Rosengren ◽  
B Karlsson ◽  
J E Olsson ◽  
V Zbornikova ◽  
...  

1998 ◽  
Vol 4 (4) ◽  
pp. E4
Author(s):  
Elizabeth Noll ◽  
Peter McL. Black

It has been demonstrated that glial fibrillary acidic protein (GFAP)-positive astrocyte precursors will differentiate in response to application of retinoic acid (RA), whereas GFAP/oligodendrocyte type 2-astrocyte progenitors will be inhibited from differentiating and continue to be mitotically active in the presence of RA. The authors sought to determine if cells taken from glial tumors that were GFAP positive retained the ability to differentiate following application of RA in vitro, as their normal astrocytic counterparts do. Primary cultures of seven astrocytic tumors were observed to have significantly fewer cells following 1 month of continuous exposure to 100 μM RA. Comparisons with sister control cultures indicated that in control conditions the tumor cells had undergone proliferation, whereas the number of cells in the RA-exposed cultures remained closer to the number of cells initially plated. This response to RA was demonstrated to be specific to the astrocytic tumors by virtue of the fact that cultures of normal brain and an anaplastic ependymoma both showed a strong proliferative response to retinoids.


Pathology ◽  
1983 ◽  
Vol 15 (4) ◽  
pp. 373-378 ◽  
Author(s):  
Stephen J. Lolait ◽  
J.H. Harmer ◽  
G. Auteri ◽  
J.S. Pedersen ◽  
B.H. Toh

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