The Value of Immunohistochemistry of Pleural Biopsy Specimens in the Differential Diagnosis between Malignant Mesothelioma and Metastatic Carcinoma

1994 ◽  
Vol 190 (11) ◽  
pp. 1044-1055 ◽  
Author(s):  
A. Grove ◽  
S.M. Paulsen ◽  
M. Gregersen
Keyword(s):  
Differential Diagnosis ◽  
Malignant Mesothelioma ◽  
Metastatic Carcinoma ◽  
Pleural Biopsy ◽  
Biopsy Specimens

Differential Diagnosis of Benign and Malignant Mesothelial Proliferations on Pleural Biopsies

2005 ◽  
Vol 129 (11) ◽  
pp. 1421-1427 ◽  
Author(s):  
Philip T. Cagle ◽  
Andrew Churg
Keyword(s):  
United States ◽  
Differential Diagnosis ◽  
Malignant Mesothelioma ◽  
The United States ◽  
Diagnostic Challenge ◽  
Pleural Biopsy ◽  
Reliable Criterion ◽  
Tissue Invasion ◽  
Reactive Hyperplasia ◽  
Diffuse Malignant Mesothelioma

Abstract Context.—Although much of the pathology literature focuses on differential diagnosis of diffuse malignant mesothelioma from other types of cancer, the primary diagnostic challenge facing the pathologist is often whether a mesothelial proliferation on a pleural biopsy represents a malignancy or a benign reactive hyperplasia. Design.—Based on previous medical publications, extensive personal consultations, and experience on the United States–Canadian Mesothelioma Reference Panel and the International Mesothelioma Panel, salient information was determined about interpretation of benign versus malignant mesothelial proliferations on pleural biopsies. Results.—Differentiation of benign reactive mesothelial hyperplasia from diffuse malignant mesothelioma is often difficult. Benign reactive mesothelial hyperplasia may mimic many features ordinarily associated with malignancy, and diffuse malignant mesothelioma may be cytologically bland. Entrapment of benign reactive mesothelial cells within organizing pleuritis may mimic tissue invasion. Conclusions.—Various histologic clues favor a benign over a malignant mesothelial proliferation and vice versa. Invasion is the most reliable criterion for determining that a mesothelial proliferation is malignant. When there is any doubt that a pleural biopsy represents a malignancy, we recommend a diagnosis of atypical mesothelial proliferation.

Primary Pleural Neoplasia: Entities Other Than Diffuse Malignant Mesothelioma

2008 ◽  
Vol 132 (7) ◽  
pp. 1149-1170 ◽  
Author(s):  
Donald G. Guinee ◽  
Timothy Craig Allen
Keyword(s):  
Differential Diagnosis ◽  
Literature Review ◽  
Malignant Mesothelioma ◽  
Correct Diagnosis ◽  
Metastatic Carcinoma ◽  
Data Sources ◽  
Pleural Tumor ◽  
Neoplasm Primary ◽  
Diffuse Malignant Mesothelioma ◽  
Pleural Neoplasms

Abstract Context.—Overwhelmingly, the most common neoplasm involving the pleura is metastatic carcinoma. In contrast, diffuse malignant mesothelioma occurs relatively rarely; however, it is nonetheless the most common neoplasm primary to the pleura. Metastatic carcinoma and diffuse malignant mesothelioma each have their own prognostic and therapeutic characteristics. Other primary pleural neoplasms occur uncommonly or rarely, with their own prognostic and therapeutic characteristics. Objective.—To review primary pleural neoplasms other than diffuse malignant mesothelioma, to better ensure correct diagnosis and optimal assessment of prognosis and treatment. Data Sources.—Literature review and primary material from the authors' institutions. Conclusions.—A nonexhaustive group of uncommon to rare benign and malignant primary pleural neoplasms— other than diffuse malignant mesothelioma—are presented, of which one must be aware in order to maintain an appropriate index of suspicion to include them in the differential diagnosis of a pleural tumor.

Recognition of Histopathologic Patterns of Diffuse Malignant Mesothelioma in Differential Diagnosis of Pleural Biopsies

2005 ◽  
Vol 129 (11) ◽  
pp. 1415-1420 ◽  
Author(s):  
Timothy Craig Allen
Keyword(s):  
Differential Diagnosis ◽  
Malignant Mesothelioma ◽  
Pleural Biopsy ◽  
Histologic Types ◽  
Diffuse Malignant Mesothelioma

Abstract Context.—Diffuse malignant mesothelioma is generally divided into 3 basic histologic types—epithelial, biphasic, or sarcomatous. However, a great diversity of histologic patterns exists within these 3 basic histologic types. Design.—The diverse histologic patterns of diffuse malignant mesothelioma are briefly described, including infrequently encountered patterns. Results. The histologic patterns of diffuse malignant mesothelioma provide a wide variation of features for the pathologist to consider in the differential diagnosis of a pleural biopsy. Conclusion.—Pathologists should be aware of the varied histologic patterns of diffuse malignant mesothelioma when evaluating pleural biopsies.

The Role of CD90 in the Differential Diagnosis of Pleural Malignant Mesothelioma, Pulmonary Carcinoma and Comparison with Calretının

2016 ◽  
Vol 23 (3) ◽  
pp. 487-491 ◽  
Author(s):  
Nurhan Sahin ◽  
Ayse Nur Akatli ◽  
Muhammet Reha Celik ◽  
Hakkı Ulutas ◽  
Emine Turkmen Samdanci ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Malignant Mesothelioma ◽  
Pulmonary Carcinoma ◽  
Pleural Malignant Mesothelioma

scholarly journals Cytological differential diagnosis of reactive mesothelia and epithelial malignant mesothelioma in effusion fluid

2009 ◽  
Vol 48 (5) ◽  
pp. 327-335 ◽  
Author(s):  
Kunimitsu KAWAHARA ◽  
Teruaki NAGANO ◽  
Shigekatsu OHYAMA ◽  
Koji ASAI ◽  
Yaeko NOBE ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Malignant Mesothelioma ◽  
Effusion Fluid

scholarly journals Necrotizing leukocytoclastic vasculitis mimicking necrotizing fasciitis: a case report

2016 ◽  
Vol 2 (3) ◽  
pp. 193
Author(s):  
Mehmet Salih Soylemez ◽  
Korhan Ozkan ◽  
Bulent Kılıc ◽  
Samet Erinc ◽  
Irfan Esenkaya ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Laboratory Test ◽  
Necrotizing Fasciitis ◽  
Immunofluorescence Microscopy ◽  
Leukocytoclastic Vasculitis ◽  
Maculopapular Rash ◽  
Skin Manifestation ◽  
Biopsy Specimens ◽  
Common Skin

<p>There are several subtypes of necrotizing leukocytoclastic vasculitis, which are classified according to their morphological features in biopsy specimens using immunofluorescence microscopy. Necrotizing leukocytoclastic vasculitis is limited to the skin, predominantly that of the lower extremities, and usually spares the palms and soles. The most common skin manifestation is palpable purpura. Other skin manifestations include maculopapular rash, bullae, papules, nodules, ulcers and livedo reticularis. There is no specific laboratory test to determine the diagnosis. There are various diseases presenting with these nonspecific symptoms, and a rapid differential diagnosis must be conducted, because the appropriate differentiation and diagnosis markedly influence the treatment strategy and survival of patients. In this study, we report a case of necrotizing leukocytoclastic vasculitis<strong> </strong>presenting with internal organ involvement and symptoms of necrotizing fasciitis, with emphasis on the clinical differentiation.</p>

Is 18F-FDG PET/CT capable of differential diagnosis from tuberculous pleurisy from malignant mesothelioma?

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Özlem Özmen ◽  
Ebru Tatci ◽  
Ş. Mustafa Demiröz ◽  
Zuhal Tazeler ◽  
Funda Demirağ
Keyword(s):  
Differential Diagnosis ◽  
Malignant Mesothelioma ◽  
Fdg Pet ◽  
Pet Ct ◽  
Tuberculous Pleurisy ◽  
18F Fdg ◽  
Fdg Pet Ct

Guidelines for Pathologic Diagnosis of Malignant Mesothelioma: A Consensus Statement from the International Mesothelioma Interest Group

2009 ◽  
Vol 133 (8) ◽  
pp. 1317-1331 ◽  
Author(s):  
Aliya N. Husain ◽  
Thomas V. Colby ◽  
Nelson G. Ordóñez ◽  
Thomas Krausz ◽  
Alain Borczuk ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Interest Group ◽  
Malignant Mesothelioma ◽  
Consensus Statement ◽  
Spindle Cell ◽  
Cytologic Diagnosis ◽  
Pathologic Diagnosis ◽  
Practical Guidelines ◽  
Colonic Adenocarcinomas ◽  
Sarcomatoid Mesothelioma

Abstract Context.—Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose. Objective.—To develop practical guidelines for the pathologic diagnosis of MM. Data Sources.—A pathology panel was convened at the International Mesothelioma Interest Group biennial meeting (October 2006). Pathologists with an interest in the field also contributed after the meeting. Conclusions.—There was consensus opinion regarding (1) distinguishing benign from malignant mesothelial proliferations (both epithelioid and spindle cell lesions), (2) cytologic diagnosis of MM, (3) key histologic features of pleural and peritoneal MM, (4) use of histochemical and immunohistochemical stains in the diagnosis and differential diagnosis of MM, (5) differentiating epithelioid MM from various carcinomas (lung, breast, ovarian, and colonic adenocarcinomas and squamous cell and renal cell carcinomas), (6) diagnosis of sarcomatoid mesothelioma, (7) use of molecular markers in the differential diagnosis of MM, (8) electron microscopy in the diagnosis of MM, and (9) some caveats and pitfalls in the diagnosis of MM. Immunohistochemical panels are integral to the diagnosis of MM, but the exact makeup of panels used is dependent on the differential diagnosis and on the antibodies available in a given laboratory. Immunohistochemical panels should contain both positive and negative markers. The International Mesothelioma Interest Group recommends that markers have either sensitivity or specificity greater than 80% for the lesions in question. Interpretation of positivity generally should take into account the localization of the stain (eg, nuclear versus cytoplasmic) and the percentage of cells staining (&gt;10% is suggested for cytoplasmic membranous markers). These guidelines are meant to be a practical reference for the pathologist.

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