Comparative evaluation of four urinary tubular dysfunction markers, with special references to the effects of aging and correction for creatinine concentration

2003 ◽  
Vol 143 (3) ◽  
pp. 279-290 ◽  
Author(s):  
J Moriguchi ◽  
T Ezaki ◽  
T Tsukahara ◽  
K Furuki ◽  
Y Fukui ◽  
...  
Keyword(s):  
Comparative Evaluation ◽  
Tubular Dysfunction ◽  
Creatinine Concentration ◽  
Tubular Dysfunction Markers ◽  
Effects Of Aging

Cadmium and Tubular Dysfunction Markers in Urine of Smelter Residents in Korea

Epidemiology ◽  
2011 ◽  
Vol 22 ◽  
pp. S232
Author(s):  
Sang-Yong Eom ◽  
Yun-Sik Kim ◽  
Sun-In Moon ◽  
Dong-hyuk Yim ◽  
Jung-Duk Park ◽  
...  
Keyword(s):  
Tubular Dysfunction ◽  
Tubular Dysfunction Markers

scholarly journals Longitudinal characterization of renal proximal tubular markers in normotensive and preeclamptic pregnancies

2017 ◽  
Vol 312 (5) ◽  
pp. R773-R778 ◽  
Author(s):  
Elisabeth Codsi ◽  
Vesna D. Garovic ◽  
Maria L. Gonzalez-Suarez ◽  
Natasa Milic ◽  
Kristi S. Borowski ◽  
...  
Keyword(s):  
Cell Injury ◽  
Gestational Hypertension ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Enzyme Linked Immunosorbent Assay ◽  
Tubular Dysfunction ◽  
Second Trimester ◽  
Tubular Injury ◽  
Creatinine Concentration ◽  
Proximal Tubular

Glomerular damage is common in preeclampsia (PE), but the extent and etiology of tubular injury are not well understood. The aim of this study was to evaluate tubular injury in patients with PE and to assess whether it predates clinical disease. We performed a prospective cohort study of 315 pregnant women who provided urine samples at the end of the second trimester and at delivery. This analysis included women who developed PE ( n = 15), gestational hypertension (GH; n = 14), and normotensive controls (NC; n = 44). Urinary markers of tubular injury, α1-microglobulin (A1M), retinol-binding protein (RBP), kidney-injury molecule-1 (KIM1), complement C5b-9, tissue inhibitor metalloproteinase-2 (TIMP-2), and insulin-like growth factor binding protein-7 (IGFBP-7) were measured by enzyme-linked immunosorbent assay (ELISA) and reported in relation to urine creatinine concentration. Second-trimester concentrations of all markers were similar among groups. At delivery, A1M concentrations were higher in the PE group than in the GH and NC groups as an A1M/creatinine ratio >13 (66.7, 8.3, and 35%, respectively, P = 0.01). Concentrations of C5b-9 were higher in the PE group than in the GH and NC groups (medians 9.85, 0.05, and 0.28 ng/mg, respectively, P = 0.003). KIM1, RBP, TIMP-2, and IGFBP-7 concentrations did not differ among groups at delivery. In conclusion, proximal tubular dysfunction, as assessed by A1M and C5b-9, developed during the interval between the end of the second trimester and delivery in patients with PE. However, this was not matched by abnormalities in markers previously associated with tubular cell injury (KIM-1, IGFBP-7, and TIMP-2).

scholarly journals Urinary Fractional Clearance of Sodium in 8 Healthy Beagle Dogs Fed Normal, Low, or Ultralow Sodium Diets

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
R. G. Lobetti
Keyword(s):  
Daily Variation ◽  
Sodium Intake ◽  
Sodium Content ◽  
Dietary Sodium ◽  
Tubular Dysfunction ◽  
Beagle Dogs ◽  
Daily Fluctuation ◽  
Creatinine Concentration ◽  
Spot Urine ◽  
Fractional Clearance

The purpose of this study was to investigate in healthy adult dogs if there was a daily fluctuation in the FCNa, the role that dietary sodium intake played on the FCNa, and the role that feeding played on the obtained value for FCNa. Three different diets were used in a group of 8 healthy beagle dogs in a crossover design. The sodium content of the diets was normal (0.26%), low (0.18%), and ultralow (0.06%). Spot urine and blood samples were collected from which the urine and serum sodium and creatinine concentration were determined, and the FCNa was calculated. The median FCNa for the normal, low, and ultralow sodium diets was 0.5, 0.77, and 0.15, respectively. Individual dogs showed a daily variation in FCNa, and samples which were collected shortly after eating showed the greatest variation. This study showed that in a group of healthy beagle dogs without obvious renal disease, the FCNa could exceed 1 and that there was both an individual and daily variation in the FCNa. The greatest variation was seen whilst the dogs were fed the low and ultralow sodium diets and when the samples were collected shortly after eating. This study concluded that an FCNa > 1% may not be indicative of acute tubular dysfunction in young dogs, and use of the FCNa for assessing renal function in clinical cases should take into account the animal’s diet, as well as the time the samples were taken in relation to feeding.

No Meaningful Increase in Urinary Tubular Dysfunction Markers in a Population with 3 μg Cadmium/g Creatinine in Urine

2006 ◽  
Vol 113 (1) ◽  
pp. 35-44 ◽  
Author(s):  
M. Ikeda ◽  
T. Ezaki ◽  
J. Moriguchi ◽  
Y. Fukui ◽  
S. Okamoto ◽  
...  
Keyword(s):  
Tubular Dysfunction ◽  
Tubular Dysfunction Markers

Lysozyme Excretion as a Measure of Renal Tubular Dysfunction in Children

1970 ◽  
Vol 39 (3) ◽  
pp. 457-465 ◽  
Author(s):  
T. M. Barratt ◽  
Rita Crawford
Keyword(s):  
Molecular Weight ◽  
Creatinine Clearance ◽  
Healthy Adults ◽  
Low Molecular Weight ◽  
Tubular Dysfunction ◽  
Renal Tubular Dysfunction ◽  
Clearance Ratio ◽  
Creatinine Concentration ◽  
Heavy Load ◽  
Protein Reabsorption

1. Activity of the low molecular weight enzyme lysozyme was measured in the plasma and urine of healthy adults and children and of children with renal disease. 2. No difference was detected between lysozyme excretion (expressed as the lysozyme/creatinine clearance ratio) of healthy adults and neonates, implying that the proximal tubular function of protein reabsorption is mature in the neonate. 3. The lysozyme/creatinine clearance ratio was not elevated in the nephrotic syndrome: thus a heavy load of filtered albumin does not interfere with low molecular weight protein reabsorption. 4. Very high values of lysozyme/creatinine clearance were observed in children with the Fanconi syndrome; there was no overlap with any other group studied. 5. Children with pyuria had a very slight increase in urine lysozyme/creatinine concentration ratio.

Effects of aging on axon terminals in the dentate molecular layer

1987 ◽  
Vol 45 ◽  
pp. 928-929
Author(s):  
K. Cullen-Dockstader ◽  
E. Fifkova
Keyword(s):  
Granule Cells ◽  
Molecular Layer ◽  
Age Groups ◽  
Long Term Potentiation ◽  
Male Rats ◽  
Perforant Path ◽  
Axon Terminals ◽  
Fischer 344 ◽  
Spatial Memory Deficit ◽  
Effects Of Aging

Normal aging results in a pronounced spatial memory deficit associated with a rapid decay of long-term potentiation at the synapses between the perforant path and spines in the medial and distal thirds of the dentate molecular layer (DML), suggesting the alteration of synaptic transmission in the dentate fascia. While the number of dentate granule cells remains unchanged, and there are no obvious pathological changes in these cells associated with increasing age, the density of their axospinous contacts has been shown to decrease. There are indications that the presynaptic element is affected by senescence before the postsynaptic element, yet little attention has been given to the fine structure of the remaining axon terminals. Therefore, we studied the axon terminals of the perforant path in the DML across three age groups.5 Male rats (Fischer 344) of each age group (3, 24 and 30 months), were perfused through the aorta.

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