Effect of Azone upon the in vivo antiviral efficacy of cidofovir or acyclovir topical formulations in treatment/prevention of cutaneous HSV-1 infections and its correlation with skin target site free drug concentration in hairless mice

Mohsen I Afouna; Timothy K Fincher; Abdel-Azim A Zaghloul; Indra K Reddy

doi:10.1016/s0378-5173(02)00705-6

Effect of Azone upon the in vivo antiviral efficacy of cidofovir or acyclovir topical formulations in treatment/prevention of cutaneous HSV-1 infections and its correlation with skin target site free drug concentration in hairless mice

International Journal of Pharmaceutics ◽

10.1016/s0378-5173(02)00705-6 ◽

2003 ◽

Vol 253 (1-2) ◽

pp. 159-168 ◽

Cited By ~ 19

Author(s):

Mohsen I Afouna ◽

Timothy K Fincher ◽

Abdel-Azim A Zaghloul ◽

Indra K Reddy

Keyword(s):

Drug Concentration ◽

Free Drug ◽

Target Site ◽

Free Drug Concentration ◽

Hairless Mice ◽

Topical Formulations ◽

Antiviral Efficacy ◽

Hsv 1

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Assessment of Correlation between Skin Target Site Free Drug Concentration and the in Vivo Topical Antiviral Efficacy in Hairless Mice for (E)-5-(2-Bromovinyl)-2′-Deoxyuridine and Acyclovir Formulations

Journal of Pharmaceutical Sciences ◽

10.1021/js980052a ◽

1998 ◽

Vol 87 (8) ◽

pp. 917-921 ◽

Cited By ~ 10

Author(s):

Mohsen I. Afouna ◽

Samir C. Mehta ◽

Abdel-Halim Ghanem ◽

William I. Higuchi ◽

Earl R. Kern ◽

...

Keyword(s):

Drug Concentration ◽

Free Drug ◽

Target Site ◽

Free Drug Concentration ◽

Hairless Mice ◽

Antiviral Efficacy

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Relationship of Skin Target Site Free Drug Concentration (C) to the In Vivo Efficacy: An Extensive Evaluation of the Predictive Value of the C Concept Using Acyclovir as a Model Drug

Journal of Pharmaceutical Sciences ◽

10.1021/js960515h ◽

1997 ◽

Vol 86 (7) ◽

pp. 797-801 ◽

Cited By ~ 14

Author(s):

Samir C. Mehta ◽

Mohsen I. Afouna ◽

Abdel-Halim Ghanem ◽

William I. Higuchi ◽

Earl R. Kern

Keyword(s):

Drug Concentration ◽

Predictive Value ◽

Free Drug ◽

Target Site ◽

Free Drug Concentration ◽

In Vivo Efficacy ◽

Extensive Evaluation ◽

Model Drug ◽

Relationship Of

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Significance of high skin fluxes produced by acyclovir topical formulations for achieving therapeutic levels of drug at the target site in the treatment of cutaneous HSV-1 infections in hairless mice: A closer look at the C* concept

Antiviral Research ◽

10.1016/0166-3542(95)94899-d ◽

1995 ◽

Vol 26 (3) ◽

pp. A332

Keyword(s):

Target Site ◽

Hairless Mice ◽

Topical Formulations ◽

Hsv 1

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Correlation of in vivo topical efficacies with in vitro predictions using acyclovir formulations in the treatment of cutaneous HSV-1 infections in hairless mice: an evaluation of the predictive value of the C∗ concept

Antiviral Research ◽

10.1016/0166-3542(96)80225-7 ◽

1996 ◽

Vol 29 (2-3) ◽

pp. 279-286 ◽

Cited By ~ 8

Author(s):

Phenil J. Patel ◽

Abdel-Halim Ghanem ◽

William I. Higuchi ◽

V. Srinivasan ◽

Earl R. Kern

Keyword(s):

Predictive Value ◽

Hairless Mice ◽

Hsv 1

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The P-glycoprotein-mediated relative decrease in cytosolic free drug concentration is similar for several anthracyclines with varying lipophilicity

Biochemical Pharmacology ◽

10.1016/0006-2952(95)00221-k ◽

1995 ◽

Vol 50 (7) ◽

pp. 967-974 ◽

Cited By ~ 21

Author(s):

H.Sipko Mülder ◽

Henk Dekker ◽

Herbert M. Pinedo ◽

Jan Lankelma

Keyword(s):

Drug Concentration ◽

Free Drug ◽

Free Drug Concentration ◽

P Glycoprotein ◽

Relative Decrease

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The relationship of basal cell layer drug concentration (C) to the antiviral efficacy: A rigorous evaluation of the C concept for predicting the entire range of topical efficacy of acyclovir formulations in the treatment of cutaneous HSV-1 infections in hairless mice

Antiviral Research ◽

10.1016/s0166-3542(97)83276-7 ◽

1997 ◽

Vol 34 (2) ◽

pp. A80

Keyword(s):

Basal Cell ◽

Drug Concentration ◽

Entire Range ◽

Cell Layer ◽

Basal Cell Layer ◽

Hairless Mice ◽

Rigorous Evaluation ◽

Antiviral Efficacy ◽

Relationship Of ◽

The Relationship

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Ertapenem in critically ill patients with early-onset ventilator-associated pneumonia: pharmacokinetics with special consideration of free-drug concentration

Journal of Antimicrobial Chemotherapy ◽

10.1093/jac/dkl485 ◽

2006 ◽

Vol 59 (2) ◽

pp. 277-284 ◽

Cited By ~ 75

Author(s):

O. Burkhardt ◽

V. Kumar ◽

D. Katterwe ◽

J. Majcher-Peszynska ◽

B. Drewelow ◽

...

Keyword(s):

Critically Ill ◽

Drug Concentration ◽

Critically Ill Patients ◽

Early Onset ◽

Free Drug ◽

Special Consideration ◽

Ventilator Associated Pneumonia ◽

Free Drug Concentration

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High-performance frontal analysis for the determination of the free drug concentration in protein binding equilibrium using porous polymer stationary phase.

Analytical Sciences ◽

10.2116/analsci.6.355 ◽

1990 ◽

Vol 6 (3) ◽

pp. 355-359 ◽

Cited By ~ 23

Author(s):

Naohiro NISHIMURA ◽

Akimasa SHIBUKAWA ◽

Terumichi NAKAGAWA

Keyword(s):

Protein Binding ◽

Stationary Phase ◽

Drug Concentration ◽

High Performance ◽

Free Drug ◽

Porous Polymer ◽

Frontal Analysis ◽

Free Drug Concentration

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The absence of stereoselective P-glycoprotein- and multidrug resistance-associated protein-mediated transport of daunorubicin11Abbreviations: P-gp, P-glycoprotein; MRP1, multidrug resistance-associated protein; DNR, daunorubicin; WP900, daunorubicin enantiomer; Ci, intracellular free drug concentration in the cytosol; Ce: extracellular free drug concentration; Cn1, overall concentration of drug accumulated inside the cell (in the nucleus and in the acidic compartment); Cn, overall concentration of drug bound to the nucleus; Cn1 (or Cn), intracellular drug concentration; CCA, concanamycin A; and RF, resistance factor.

Biochemical Pharmacology ◽

10.1016/s0006-2952(01)00703-1 ◽

2001 ◽

Vol 62 (5) ◽

pp. 561-567 ◽

Cited By ~ 7

Author(s):

Chatchanok Loetchutinat ◽

Christine Heywang ◽

Waldemar Priebe ◽

Arlette Garnier-Suillerot

Keyword(s):

Multidrug Resistance ◽

Drug Concentration ◽

Free Drug ◽

Resistance Factor ◽

Free Drug Concentration ◽

Concanamycin A ◽

P Glycoprotein ◽

Acidic Compartment

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Monitoring Free Drug Concentration

Handbook of Drug Monitoring Methods ◽

10.1007/978-1-59745-031-7_2 ◽

2007 ◽

pp. 41-65

Author(s):

Amitava Dasgupta

Keyword(s):

Drug Concentration ◽

Free Drug ◽

Free Drug Concentration

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Effect of Azone upon the in vivo antiviral efficacy of cidofovir or acyclovir topical formulations in treatment/prevention of cutaneous HSV-1 infections and its correlation with skin target site free drug concentration in hairless mice

Assessment of Correlation between Skin Target Site Free Drug Concentration and the in Vivo Topical Antiviral Efficacy in Hairless Mice for (E)-5-(2-Bromovinyl)-2′-Deoxyuridine and Acyclovir Formulations

Relationship of Skin Target Site Free Drug Concentration (C*) to the In Vivo Efficacy: An Extensive Evaluation of the Predictive Value of the C* Concept Using Acyclovir as a Model Drug

Significance of high skin fluxes produced by acyclovir topical formulations for achieving therapeutic levels of drug at the target site in the treatment of cutaneous HSV-1 infections in hairless mice: A closer look at the C* concept

Correlation of in vivo topical efficacies with in vitro predictions using acyclovir formulations in the treatment of cutaneous HSV-1 infections in hairless mice: an evaluation of the predictive value of the C∗ concept

The P-glycoprotein-mediated relative decrease in cytosolic free drug concentration is similar for several anthracyclines with varying lipophilicity

The relationship of basal cell layer drug concentration (C*) to the antiviral efficacy: A rigorous evaluation of the C* concept for predicting the entire range of topical efficacy of acyclovir formulations in the treatment of cutaneous HSV-1 infections in hairless mice

Ertapenem in critically ill patients with early-onset ventilator-associated pneumonia: pharmacokinetics with special consideration of free-drug concentration

High-performance frontal analysis for the determination of the free drug concentration in protein binding equilibrium using porous polymer stationary phase.

Monitoring Free Drug Concentration

Relationship of Skin Target Site Free Drug Concentration (C) to the In Vivo Efficacy: An Extensive Evaluation of the Predictive Value of the C Concept Using Acyclovir as a Model Drug

The relationship of basal cell layer drug concentration (C) to the antiviral efficacy: A rigorous evaluation of the C concept for predicting the entire range of topical efficacy of acyclovir formulations in the treatment of cutaneous HSV-1 infections in hairless mice