Assessment of Correlation between Skin Target Site Free Drug Concentration and the in Vivo Topical Antiviral Efficacy in Hairless Mice for (E)-5-(2-Bromovinyl)-2′-Deoxyuridine and Acyclovir Formulations

Mohsen I. Afouna; Samir C. Mehta; Abdel-Halim Ghanem; William I. Higuchi; Earl R. Kern; Erik De Clercq; Hamed H. El-Shattawy

doi:10.1021/js980052a

Assessment of Correlation between Skin Target Site Free Drug Concentration and the in Vivo Topical Antiviral Efficacy in Hairless Mice for (E)-5-(2-Bromovinyl)-2′-Deoxyuridine and Acyclovir Formulations

Journal of Pharmaceutical Sciences ◽

10.1021/js980052a ◽

1998 ◽

Vol 87 (8) ◽

pp. 917-921 ◽

Cited By ~ 10

Author(s):

Mohsen I. Afouna ◽

Samir C. Mehta ◽

Abdel-Halim Ghanem ◽

William I. Higuchi ◽

Earl R. Kern ◽

...

Keyword(s):

Drug Concentration ◽

Free Drug ◽

Target Site ◽

Free Drug Concentration ◽

Hairless Mice ◽

Antiviral Efficacy

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Effect of Azone upon the in vivo antiviral efficacy of cidofovir or acyclovir topical formulations in treatment/prevention of cutaneous HSV-1 infections and its correlation with skin target site free drug concentration in hairless mice

International Journal of Pharmaceutics ◽

10.1016/s0378-5173(02)00705-6 ◽

2003 ◽

Vol 253 (1-2) ◽

pp. 159-168 ◽

Cited By ~ 19

Author(s):

Mohsen I Afouna ◽

Timothy K Fincher ◽

Abdel-Azim A Zaghloul ◽

Indra K Reddy

Keyword(s):

Drug Concentration ◽

Free Drug ◽

Target Site ◽

Free Drug Concentration ◽

Hairless Mice ◽

Topical Formulations ◽

Antiviral Efficacy ◽

Hsv 1

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Relationship of Skin Target Site Free Drug Concentration (C) to the In Vivo Efficacy: An Extensive Evaluation of the Predictive Value of the C Concept Using Acyclovir as a Model Drug

Journal of Pharmaceutical Sciences ◽

10.1021/js960515h ◽

1997 ◽

Vol 86 (7) ◽

pp. 797-801 ◽

Cited By ~ 14

Author(s):

Samir C. Mehta ◽

Mohsen I. Afouna ◽

Abdel-Halim Ghanem ◽

William I. Higuchi ◽

Earl R. Kern

Keyword(s):

Drug Concentration ◽

Predictive Value ◽

Free Drug ◽

Target Site ◽

Free Drug Concentration ◽

In Vivo Efficacy ◽

Extensive Evaluation ◽

Model Drug ◽

Relationship Of

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The P-glycoprotein-mediated relative decrease in cytosolic free drug concentration is similar for several anthracyclines with varying lipophilicity

Biochemical Pharmacology ◽

10.1016/0006-2952(95)00221-k ◽

1995 ◽

Vol 50 (7) ◽

pp. 967-974 ◽

Cited By ~ 21

Author(s):

H.Sipko Mülder ◽

Henk Dekker ◽

Herbert M. Pinedo ◽

Jan Lankelma

Keyword(s):

Drug Concentration ◽

Free Drug ◽

Free Drug Concentration ◽

P Glycoprotein ◽

Relative Decrease

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The relationship of basal cell layer drug concentration (C) to the antiviral efficacy: A rigorous evaluation of the C concept for predicting the entire range of topical efficacy of acyclovir formulations in the treatment of cutaneous HSV-1 infections in hairless mice

Antiviral Research ◽

10.1016/s0166-3542(97)83276-7 ◽

1997 ◽

Vol 34 (2) ◽

pp. A80

Keyword(s):

Basal Cell ◽

Drug Concentration ◽

Entire Range ◽

Cell Layer ◽

Basal Cell Layer ◽

Hairless Mice ◽

Rigorous Evaluation ◽

Antiviral Efficacy ◽

Relationship Of ◽

The Relationship

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Ertapenem in critically ill patients with early-onset ventilator-associated pneumonia: pharmacokinetics with special consideration of free-drug concentration

Journal of Antimicrobial Chemotherapy ◽

10.1093/jac/dkl485 ◽

2006 ◽

Vol 59 (2) ◽

pp. 277-284 ◽

Cited By ~ 75

Author(s):

O. Burkhardt ◽

V. Kumar ◽

D. Katterwe ◽

J. Majcher-Peszynska ◽

B. Drewelow ◽

...

Keyword(s):

Critically Ill ◽

Drug Concentration ◽

Critically Ill Patients ◽

Early Onset ◽

Free Drug ◽

Special Consideration ◽

Ventilator Associated Pneumonia ◽

Free Drug Concentration

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High-performance frontal analysis for the determination of the free drug concentration in protein binding equilibrium using porous polymer stationary phase.

Analytical Sciences ◽

10.2116/analsci.6.355 ◽

1990 ◽

Vol 6 (3) ◽

pp. 355-359 ◽

Cited By ~ 23

Author(s):

Naohiro NISHIMURA ◽

Akimasa SHIBUKAWA ◽

Terumichi NAKAGAWA

Keyword(s):

Protein Binding ◽

Stationary Phase ◽

Drug Concentration ◽

High Performance ◽

Free Drug ◽

Porous Polymer ◽

Frontal Analysis ◽

Free Drug Concentration

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The absence of stereoselective P-glycoprotein- and multidrug resistance-associated protein-mediated transport of daunorubicin11Abbreviations: P-gp, P-glycoprotein; MRP1, multidrug resistance-associated protein; DNR, daunorubicin; WP900, daunorubicin enantiomer; Ci, intracellular free drug concentration in the cytosol; Ce: extracellular free drug concentration; Cn1, overall concentration of drug accumulated inside the cell (in the nucleus and in the acidic compartment); Cn, overall concentration of drug bound to the nucleus; Cn1 (or Cn), intracellular drug concentration; CCA, concanamycin A; and RF, resistance factor.

Biochemical Pharmacology ◽

10.1016/s0006-2952(01)00703-1 ◽

2001 ◽

Vol 62 (5) ◽

pp. 561-567 ◽

Cited By ~ 7

Author(s):

Chatchanok Loetchutinat ◽

Christine Heywang ◽

Waldemar Priebe ◽

Arlette Garnier-Suillerot

Keyword(s):

Multidrug Resistance ◽

Drug Concentration ◽

Free Drug ◽

Resistance Factor ◽

Free Drug Concentration ◽

Concanamycin A ◽

P Glycoprotein ◽

Acidic Compartment

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Monitoring Free Drug Concentration

Handbook of Drug Monitoring Methods ◽

10.1007/978-1-59745-031-7_2 ◽

2007 ◽

pp. 41-65

Author(s):

Amitava Dasgupta

Keyword(s):

Drug Concentration ◽

Free Drug ◽

Free Drug Concentration

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HPLC-MS/MS coupled with equilibrium dialysis method for quantification of free drug concentration of pazopanib in plasma

Heliyon ◽

10.1016/j.heliyon.2020.e03813 ◽

2020 ◽

Vol 6 (4) ◽

pp. e03813

Author(s):

Yi Long Toh ◽

Yi Yun Pang ◽

Maung Shwe ◽

Ravindran Kanesvaran ◽

Chee Keong Toh ◽

...

Keyword(s):

Drug Concentration ◽

Equilibrium Dialysis ◽

Free Drug ◽

Free Drug Concentration ◽

Dialysis Method

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Equilibrium sampling through membrane based on a single hollow fibre for determination of drug–protein binding and free drug concentration in plasma

Journal of Chromatography B ◽

10.1016/j.jchromb.2005.08.020 ◽

2005 ◽

Vol 826 (1-2) ◽

pp. 169-176 ◽

Cited By ~ 21

Author(s):

Tatjana Trtić-Petrović ◽

Jing-Fu Liu ◽

Jan Åke Jönsson

Keyword(s):

Protein Binding ◽

Drug Concentration ◽

Hollow Fibre ◽

Free Drug ◽

Free Drug Concentration ◽

Drug Protein Binding

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Assessment of Correlation between Skin Target Site Free Drug Concentration and the in Vivo Topical Antiviral Efficacy in Hairless Mice for (E)-5-(2-Bromovinyl)-2′-Deoxyuridine and Acyclovir Formulations

Effect of Azone upon the in vivo antiviral efficacy of cidofovir or acyclovir topical formulations in treatment/prevention of cutaneous HSV-1 infections and its correlation with skin target site free drug concentration in hairless mice

Relationship of Skin Target Site Free Drug Concentration (C*) to the In Vivo Efficacy: An Extensive Evaluation of the Predictive Value of the C* Concept Using Acyclovir as a Model Drug

The P-glycoprotein-mediated relative decrease in cytosolic free drug concentration is similar for several anthracyclines with varying lipophilicity

The relationship of basal cell layer drug concentration (C*) to the antiviral efficacy: A rigorous evaluation of the C* concept for predicting the entire range of topical efficacy of acyclovir formulations in the treatment of cutaneous HSV-1 infections in hairless mice

Ertapenem in critically ill patients with early-onset ventilator-associated pneumonia: pharmacokinetics with special consideration of free-drug concentration

High-performance frontal analysis for the determination of the free drug concentration in protein binding equilibrium using porous polymer stationary phase.

Monitoring Free Drug Concentration

HPLC-MS/MS coupled with equilibrium dialysis method for quantification of free drug concentration of pazopanib in plasma

Equilibrium sampling through membrane based on a single hollow fibre for determination of drug–protein binding and free drug concentration in plasma

Relationship of Skin Target Site Free Drug Concentration (C) to the In Vivo Efficacy: An Extensive Evaluation of the Predictive Value of the C Concept Using Acyclovir as a Model Drug

The relationship of basal cell layer drug concentration (C) to the antiviral efficacy: A rigorous evaluation of the C concept for predicting the entire range of topical efficacy of acyclovir formulations in the treatment of cutaneous HSV-1 infections in hairless mice