The absence of stereoselective P-glycoprotein- and multidrug resistance-associated protein-mediated transport of daunorubicin11Abbreviations: P-gp, P-glycoprotein; MRP1, multidrug resistance-associated protein; DNR, daunorubicin; WP900, daunorubicin enantiomer; Ci, intracellular free drug concentration in the cytosol; Ce: extracellular free drug concentration; Cn1, overall concentration of drug accumulated inside the cell (in the nucleus and in the acidic compartment); Cn, overall concentration of drug bound to the nucleus; Cn1 (or Cn), intracellular drug concentration; CCA, concanamycin A; and RF, resistance factor.
2001 ◽
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