Prognostic value of early somatosensory evoked potentials for adverse outcome in full-term infants with birth asphyxia

Abstract OBJECTIVE: To explore the capacity of somatosensory evoked potentials (SEP) to assess maturation processes in the development of the nervous system, and the characteristics of SEP in healthy full-term infants and full-term newborns with perinatal asphyxia and their follow up until the age of 14 months. MATERIALS AND METHODS: SEP were studied in 21 healthy full-term infants and 38 full-term newborns with perinatal asphyxia. The children with asphyxia were studied longitudinally until they were 14 months old. To assess the SEP we measured the latency of the P15, N20 and P25 components, the amplitude ratio N20/ P25 and inter-peak intervals P15-N20 and N20-P25. RESULTS: The component that was most typically always found in the SEP recordings of both healthy infants and those with perinatal asphyxia was N20. The mean latency values of P15, N20 and P25 were higher in the children with perinatal asphyxia (p ⋋ 0.001). The SEP amplitude was highly variable (CoV% = 76.6%). The latencies became shorter with age in asphyxia patients aged 0 to 14 months, the shortening being the greatest in the first trimester, while they showed no statistically significant differences in infants aged 6 to 12 months. CONCLUSIONS: SEPs in the neonatal period differ considerably from those of adults and older children in the morphology and longer potential latency, which can be accounted for by the incomplete myelination of nerve fibers. The changes in SEP latency in patients with HIE stages I and II follow the same pattern found in healthy children - latency became shorter with increasing age, which was most pronounced in the first 3 months. SEP latency was found to be correlated with height and age. No differences were found in the latency of potentials between healthy infants and infants with brain hemorrhage. Recording SEP is a sensitive method to assess the CNS in children with perinatal asphyxia and to monitor the maturation of the somatosensory pathway.

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Somatosensory evoked potentials are of additional prognostic value in certain patterns of brain injury in term birth asphyxia

Clinical Neurophysiology ◽

10.1016/j.clinph.2011.12.009 ◽

2012 ◽

Vol 123 (8) ◽

pp. 1631-1638 ◽

Cited By ~ 9

Author(s):

Renate M.C. Swarte ◽

Perumpillichira J. Cherian ◽

Maarten Lequin ◽

Gerhard H. Visser ◽

Paul Govaert

Keyword(s):

Brain Injury ◽

Evoked Potentials ◽

Somatosensory Evoked Potentials ◽

Prognostic Value ◽

Birth Asphyxia ◽

Term Birth

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The predictive accuracy of hypoxic scoring for prediction of adverse outcome in neonates born with asphyxia

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20200104 ◽

2020 ◽

Vol 7 (2) ◽

pp. 333

Author(s):

Muhammad Saqib ◽

Safeer A. Jamil ◽

Usman Arif ◽

Zubda Anwar ◽

Sarosh Waheed ◽

...

Keyword(s):

Predictive Accuracy ◽

Adverse Outcome ◽

Birth Asphyxia ◽

Major Contributor ◽

Fetal Hypoxia ◽

Negative Data ◽

Term Infants ◽

Study Objective ◽

The Mean ◽

Sensitivity Specificity

Background: Birth asphyxia is a major contributor to neonatal mortality. Fetal hypoxia followed by asphyxia is common cause of brain injury in term infants. Hypoxia score has shown to be accurate enough to predict adverse outcome in asphyxiated neonates. But controversies exist regarding predictive accuracy of hypoxia score. So we conducted this study. Objective to assess the predictive accuracy of hypoxic scoring for prediction of adverse outcome in neonates born with asphyxia.Methods: 170 neonates were screed for hypoxia score. Neonates were labelled as positive or negative. Then all neonates were followed-up for 7 days. If neonate died within 7days, then case was confirmed as positive or negative. Data was analysed by using SPSS 20. 2x2 table was developed to calculate sensitivity, specificity, PPV, NPV and predictive accuracy of hypoxia score.Results: The mean Apgar score at birth was 5.01±0.83. The sensitivity of hypoxia score was 87.8%, specificity was 90.9%, PPV was 90%, NPV was 88.9% while predictive accuracy was 89.4% taking actual adverse outcome as gold standard.Conclusions: The predictive accuracy of hypoxia score was high for prediction of adverse outcome in asphyxiated neonates.

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