The elastin–laminin receptor-mediated matrix degradation. Effect of glucose concentration. Role in atherosclerosis

2004 ◽  
Vol 1262 ◽  
pp. 411-413 ◽  
Author(s):  
Gilles Faury ◽  
J. Verdetti ◽  
T. Fülöp ◽  
L. Robert
Keyword(s):  
Glucose Concentration ◽  
Laminin Receptor ◽  
Matrix Degradation ◽  
Effect Of Glucose ◽  
Degradation Effect

Effect of Glucose Concentration on Formation of AGEs in Erythrocytesin Vitro

2005 ◽  
Vol 1043 (1) ◽  
pp. 146-150 ◽  
Author(s):  
RYOJI NAGAI ◽  
ELIZABETH K. DEEMER ◽  
JONATHAN W. BROCK ◽  
SUZANNE R. THORPE ◽  
JOHN W. BAYNES
Keyword(s):  
Glucose Concentration ◽  
Effect Of Glucose

Effect of Glucose Concentration on Respiration of Rous Sarcoma and of Chorioallantoic Membrane

Nature ◽  
1960 ◽  
Vol 188 (4746) ◽  
pp. 229-230 ◽  
Author(s):  
ALVIN S. LEVINE ◽  
FRANCES STRICKER ◽  
RICHARD UHL ◽  
JAMES ASHMORE
Keyword(s):  
Glucose Concentration ◽  
Chorioallantoic Membrane ◽  
Rous Sarcoma ◽  
Effect Of Glucose

The effects of glucose and insulin on contraction of the isolated diaphragm

1977 ◽  
Vol 55 (4) ◽  
pp. 868-881 ◽  
Author(s):  
G. W. Mainwood ◽  
D. Cechetto ◽  
Monique St. Jean
Keyword(s):  
Muscle Fibre ◽  
Isometric Contraction ◽  
Glucose Concentration ◽  
Compartment Model ◽  
Osmotic Gradient ◽  
Model Calculations ◽  
Two Compartment Model ◽  
The Mean ◽  
Effect Of Glucose ◽  
Intracellular Glucose

High glucose concentrations (55 mM) were found to suppress the isometric contraction tension of rat diaphragm. The effect appears to be due to the resulting transmembrane osmotic gradient in spite of the fact that glucose uptake by the diaphragm is fairly rapid. Insulin can reverse the effect of hypertonic glucose to a considerable extent. The problems of estimating intracellular glucose concentration in the isolated muscle are considered. Estimates of intracellular glucose taking into account extracellular space and extracellular diffusion gradients were made using a two-compartment model. Calculations based on the model show that in the presence of insulin, intracellular glucose increases from about 1 to 19 μmol/ml of muscle fibre. The mean transmembrane glucose concentration gradient decreases from 41 to 18 μmol/ml. With the use of the model it appears possible to relate most of the observed effect of glucose and insulin on isometric contraction to their influence on the osmotic gradient across the muscle fibre membrane. Insulin appears to have some additional effects on muscles suppressed by hypertonic solutions which are not accounted for by this mechanism.

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