A magnetic resonance imaging based method for measurement of tissue iron concentration in liver arterially embolized with ferrimagnetic particles designed for magnetic hyperthermia treatment of tumors

2003 ◽  
Vol 21 (5) ◽  
pp. 483-488 ◽  
Author(s):  
H Pardoe ◽  
P.R Clark ◽  
T.G St. Pierre ◽  
P Moroz ◽  
S.K Jones
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Iron Concentration ◽  
Magnetic Hyperthermia ◽  
Resonance Imaging ◽  
Hyperthermia Treatment ◽  
Tissue Iron

scholarly journals Di- and tri-component spinel ferrite nanocubes: synthesis and their comparative characterization for theranostic applications

Nanoscale ◽  
2021 ◽  
Author(s):  
Niccolò Silvestri ◽  
Helena Gavilán ◽  
Pablo Guardia ◽  
Rosaria Brescia ◽  
Soraia Fernandes ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Properties ◽  
Magnetic Resonance ◽  
Magnetic Particles ◽  
Spinel Ferrite ◽  
Magnetic Hyperthermia ◽  
Resonance Imaging ◽  
Hyperthermia Treatment ◽  
Theranostic Applications ◽  
Mixed Transition

Mixed transition metals ferrites nanocubes are here prepared. Their magnetic properties are evaluated to assess their applicability as theranostic tools for magnetic hyperthermia treatment, magnetic resonance imaging and magnetic particles imaging.

scholarly journals Noninvasive assessment of iron overload by magnetic resonance imaging

2020 ◽  
Vol 19 (3) ◽  
pp. 158-163
Author(s):  
E. E. Nazarova ◽  
D. A. Kupriyanov ◽  
G. A. Novichkova ◽  
G. V. Tereshchenko
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Iron Overload ◽  
Serum Ferritin ◽  
Serum Ferritin Level ◽  
Ferritin Level ◽  
Iron Concentration ◽  
The Body ◽  
Iron Accumulation ◽  
Resonance Imaging

The assessment of iron accumulation in the body is important for the diagnosis of iron overload syndrome or planning and monitoring of the chelation therapy. Excessive iron accumulation in the organs leads to their toxic damage and dysfunction. Until recently iron estimation was performed either directly by liver iron concentration and/or indirectly by measuring of serum ferritin level. However, noninvasive iron assessment by Magnetic resonance imaging (MRI) is more accurate method unlike liver biopsy or serum ferritin level test. In this article, we demonstrate the outlines of non-invasive diagnostics of iron accumulation by MRI and its specifications.

Magnetic nanoparticle-induced hyperthermia treatment under magnetic resonance imaging

2011 ◽  
Vol 29 (2) ◽  
pp. 272-280 ◽  
Author(s):  
Alsayed A.M. Elsherbini ◽  
Mahmoud Saber ◽  
Mohamed Aggag ◽  
Ahmed El-Shahawy ◽  
Hesham A.A. Shokier
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Magnetic Nanoparticle ◽  
Resonance Imaging ◽  
Hyperthermia Treatment ◽  
Induced Hyperthermia

Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance

Blood ◽  
2005 ◽  
Vol 105 (2) ◽  
pp. 855-861 ◽  
Author(s):  
Timothy G. St. Pierre ◽  
Paul R. Clark ◽  
Wanida Chua-anusorn ◽  
Adam J. Fleming ◽  
Gary P. Jeffrey ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Needle Biopsy ◽  
Hereditary Hemochromatosis ◽  
Iron Concentration ◽  
Relaxation Rates ◽  
Resonance Imaging ◽  
Liver Iron ◽  
Transverse Relaxation

AbstractMeasurement of liver iron concentration (LIC) is necessary for a range of iron-loading disorders such as hereditary hemochromatosis, thalassemia, sickle cell disease, aplastic anemia, and myelodysplasia. Currently, chemical analysis of needle biopsy specimens is the most common accepted method of measurement. This study presents a readily available noninvasive method of measuring and imaging LICs in vivo using clinical 1.5-T magnetic resonance imaging units. Mean liver proton transverse relaxation rates (R2) were measured for 105 humans. A value for the LIC for each subject was obtained by chemical assay of a needle biopsy specimen. High degrees of sensitivity and specificity of R2 to biopsy LICs were found at the clinically significant LIC thresholds of 1.8, 3.2, 7.0, and 15.0 mg Fe/g dry tissue. A calibration curve relating liver R2 to LIC has been deduced from the data covering the range of LICs from 0.3 to 42.7 mg Fe/g dry tissue. Proton transverse relaxation rates in aqueous paramagnetic solutions were also measured on each magnetic resonance imaging unit to ensure instrument-independent results. Measurements of proton transverse relaxivity of aqueous MnCl2 phantoms on 13 different magnetic resonance imaging units using the method yielded a coefficient of variation of 2.1%.

scholarly journals Limitations of Magnetic Resonance Imaging in Measurement of Hepatic Iron

Blood ◽  
1997 ◽  
Vol 90 (12) ◽  
pp. 4736-4742
Author(s):  
Emanuele Angelucci ◽  
Andrea Giovagnoni ◽  
Gianluca Valeri ◽  
Enrico Paci ◽  
Marta Ripalti ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Signal Intensity ◽  
Regression Line ◽  
Iron Concentration ◽  
Pulse Sequences ◽  
Thalassemia Major ◽  
Hepatic Iron ◽  
Resonance Imaging ◽  
The Relationship

To evaluate the usefulness of magnetic resonance imaging for the quantitative determination of hepatic iron, we examined 43 patients with thalassemia major and assessed the influence of pathologic changes in the liver on the precision of estimates of the hepatic iron concentration. Tissue signal intensities were measured from magnetic resonance T1-weighted images derived from gradient-echo (GE) pulse sequences and the ratio of the signal intensity of liver to muscle calculated. By excluding patients (n = 9) having a signal intensity ratio (SIR) less than or equal to 0.2, a linear relationship with hepatic iron was found and subsequent analyses were limited to these 34 patients. In 27 patients with hepatic fibrosis, an overall correlation of −0.848 was found between hepatic iron and SIR. By contrast, in the seven patients with no fibrosis, the correlation coefficient (−0.993) was significantly greater (P < .0001). Despite the differences in correlation, the regression line between hepatic iron and SIR for the patients with no fibrosis did not differ significantly with respect to either slope or intercept from that of the patients with fibrosis. Thus, the presence of fibrosis did not seem to affect the pattern of the relationship between hepatic iron and the SIR, but rather to increase the variability of the relationship. Clinically, the presence of fibrosis makes estimates of hepatic iron derived from magnetic resonance imaging so variable as to be of little practical use in the management of transfusional iron overload.

scholarly journals Limitations of Magnetic Resonance Imaging in Measurement of Hepatic Iron

Blood ◽  
1997 ◽  
Vol 90 (12) ◽  
pp. 4736-4742 ◽  
Author(s):  
Emanuele Angelucci ◽  
Andrea Giovagnoni ◽  
Gianluca Valeri ◽  
Enrico Paci ◽  
Marta Ripalti ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Signal Intensity ◽  
Regression Line ◽  
Iron Concentration ◽  
Pulse Sequences ◽  
Thalassemia Major ◽  
Hepatic Iron ◽  
Resonance Imaging ◽  
The Relationship

Abstract To evaluate the usefulness of magnetic resonance imaging for the quantitative determination of hepatic iron, we examined 43 patients with thalassemia major and assessed the influence of pathologic changes in the liver on the precision of estimates of the hepatic iron concentration. Tissue signal intensities were measured from magnetic resonance T1-weighted images derived from gradient-echo (GE) pulse sequences and the ratio of the signal intensity of liver to muscle calculated. By excluding patients (n = 9) having a signal intensity ratio (SIR) less than or equal to 0.2, a linear relationship with hepatic iron was found and subsequent analyses were limited to these 34 patients. In 27 patients with hepatic fibrosis, an overall correlation of −0.848 was found between hepatic iron and SIR. By contrast, in the seven patients with no fibrosis, the correlation coefficient (−0.993) was significantly greater (P < .0001). Despite the differences in correlation, the regression line between hepatic iron and SIR for the patients with no fibrosis did not differ significantly with respect to either slope or intercept from that of the patients with fibrosis. Thus, the presence of fibrosis did not seem to affect the pattern of the relationship between hepatic iron and the SIR, but rather to increase the variability of the relationship. Clinically, the presence of fibrosis makes estimates of hepatic iron derived from magnetic resonance imaging so variable as to be of little practical use in the management of transfusional iron overload.

scholarly journals Chelation use and iron burden in North American and British thalassemia patients: a report from the Thalassemia Longitudinal Cohort

Blood ◽  
2012 ◽  
Vol 119 (12) ◽  
pp. 2746-2753 ◽  
Author(s):  
Janet L. Kwiatkowski ◽  
Hae-Young Kim ◽  
Alexis A. Thompson ◽  
Charles T. Quinn ◽  
Brigitta U. Mueller ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Clinical Care ◽  
Iron Concentration ◽  
Dry Weight ◽  
Combination Therapies ◽  
Resonance Imaging ◽  
Liver Iron ◽  
Organ Specific

Abstract Morbidity and mortality in thalassemia are associated with iron burden. Recent advances in organ-specific iron imaging and the availability of oral deferasirox are expected to improve clinical care, but the extent of use of these resources and current chelation practices have not been well described. In the present study, we studied chelation use and the change in iron measurements in 327 subjects with transfusion-dependent thalassemia (mean entry age, 22.1 ± 2.5 years) from 2002-2011, with a mean follow-up of 8.0 years (range, 4.4-9.0 years). The predominant chelator currently used is deferasirox, followed by deferoxamine and then combination therapies. The use of both hepatic and cardiac magnetic resonance imaging increased more than 5-fold (P < .001) during the study period, leading to an 80% increase in the number of subjects undergoing liver iron concentration (LIC) measurements. Overall, LIC significantly improved (median, 10.7 to 5.1 mg/g dry weight, P < .001) with a nonsignificant improvement in cardiac T2* (median, 23.55 to 34.50 ms, P = .23). The percentage of patients with markers of inadequate chelation (ferritin > 2500 ng/mL, LIC > 15 mg/g dry weight, and/or cardiac T2* < 10 ms) also declined from 33% to 26%. In summary, increasing use of magnetic resonance imaging and oral chelation in thalassemia management has likely contributed to improved iron burden.

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