scholarly journals APPROPRIATENESS OF MYOCARDIAL REVASCULARIZATION ASSESSED BY SYNTAX SCORE II IN A CENTRE WITHOUT ON-SITE CARDIAC SURGERY

2015 ◽  
Vol 65 (10) ◽  
pp. A1583
Author(s):  
Bojan M. Stanetic ◽  
Miodrag Ostojic ◽  
Kurt Huber ◽  
Carlos Campos ◽  
Tamara Kovacevic-Preradovic ◽  
...  
2019 ◽  
pp. 17-25
Author(s):  
B.G. ALEKYAN ◽  
N.G. KARAPETYAN ◽  
V.V. KRAVCHENKO ◽  
A.SH. REVISHVILI

С момента своего внедрения в клиническую практику чрескожные коронарные вмешательства (ЧКВ) постепенно стали методом выбора при лечении пациентов с локальными и несложными поражениями венечных артерий, резистентных к оптимальной медикаментозной терапии. Несмотря на это, использование ЧКВ для лечения пациентов с тяжелыми формами поражений коронарных артерий является предметом разночтений и споров и в настоящее время. В эпоху стентов с лекарственным антипролиферативным покрытием одним из наиболее важных и значимых исследований эффективности ЧКВ и коронарного шунтирования является, бесспорно, исследование SYNTAX (Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery согласованность ЧКВ с имплантацией стентов TAXUS и кардиохирургией). Полученные в ходе данного исследования результаты легли в основу рекомендаций по реваску1 ляризации миокарда Европейского общества кардиологов (ЕОК) 2014 и 2018 гг. Однако на данный момент имеются крайне важные и принципиальные несоответствия между современной клинической практикой и рандомизированным исследованием SYNTAX. Наибо1 лее существенным недостатком шкалы риска SYNTAX считается отсутствие индивидуализированного подхода при принятии решения о выборе метода реваскуляризации миокарда в силу отсутствия в ней клинических переменных. В данной статье будет рассмотрена новая шкала риска SYNTAX Score II (SS II) как более точный инструмент принятия решения в работе сердечной команды .Since its introduction into clinical practice, percutaneous coronary interventions (PCI) have gradually become the method of choice for treating patients with local and uncomplicated lesions of the coronary arteries that are resistant to optimal medicamental therapy. Despite this, the use of PCI for the treatment of patients with coronary artery disease carts is a matter of discrepancies and disputes even today. In the era of drug1elongated antiproliferative stents, one of the most important and significant studies of the efficacy of PCI and coronary shunting (CS) is undoubtedly the SYNTAX study (Synergy between TAXUS and Cardiac Surgery implantation of TAXUS and Cardiac Surgery). The results of this study formed the basis for the latest recommendations on myocardial revascularization of the European Society of Cardiology (EOC) 2014 and beyond 2018. However, at the moment there are extremely important and fundamental inconsistencies between modern clinical practice and the randomized SYNTAX study. The most significant drawback of the SYNTAX risk scale is the lack of an individualized approach when deciding on the choice of myocardial revascularization method due to the absence of clinical variables in it. This article will look at the new Syntax Score II risk scale as a more accurate decision1making tool in the work of the heart team.Since its introduction into clinical practice, percutaneous coronary interventions (PCI) have gradually become the method of choice for treating patients with local and uncomplicated lesions of the coronary arteries that are resistant to optimal medicamental therapy. Despite this, the use of PCI for the treatment of patients with coronary artery disease carts is a matter of discrepancies and disputes even today. In the era of drug1elongated antiproliferative stents, one of the most important and significant studies of the efficacy of PCI and coronary shunting (CS) is undoubtedly the SYNTAX study (Synergy between TAXUS and Cardiac Surgery implantation of TAXUS and Cardiac Surgery). The results of this study formed the basis for the latest recommendations on myocardial revascularization of the European Society of Cardiology (EOC) 2014 and beyond 2018. However, at the moment there are extremely important and fundamental inconsistencies between modern clinical practice and the randomized SYNTAX study. The most significant drawback of the SYNTAX risk scale is the lack of an individualized approach when deciding on the choice of myocardial revascularization method due to the absence of clinical variables in it. This article will look at the new Syntax Score II risk scale as a more accurate decision1making tool in the work of the heart team.


2017 ◽  
Vol 227 ◽  
pp. 478-484 ◽  
Author(s):  
Bojan M. Stanetic ◽  
Miodrag Ostojic ◽  
Carlos M. Campos ◽  
Jelena Marinkovic ◽  
Vasim Farooq ◽  
...  

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
B Alekyan ◽  
N Karapetyan ◽  
D Kishmiryan

Abstract Introduction The most significant disadvantage of the SYNTAX score is the lack of an individualized approach due to the absence of the clinical parameters. The Syntax Score II calculator which includes 6 clinical indicators is more accurate decision-making tool that should help the “heart team” to choose a strategy for myocardial revascularization. The purpose of the study was to examine the effectiveness of using Syntax Score II for patients with multi-vessel coronary artery lesions who was dedicated to PCI. Material and methods From 01/2018 to 12/2018, 760 patients were included in the research, who was dedicated to PCI by the decision of the local “heart team”. In present analysis were included 116 (15%) of these patients with the multi-vessel coronary lesion and with a left main coronary artery lesion of different complexity. Patients who had previously undergone myocardial revascularization were excluded from analysis. The age of patients ranged from 41 to 86 years (mean age 67 + 9 years). There were males - 67.2%. Diabetes mellitus was present in 34.5% of the patients. 42.2% of the patients had angina pectoris (NYHA 3–4), and 60.3% had II class chronic heart failure. Results The average Syntax Score of the 116 patients was 23.1 + 7.8 (from 11 to 59). Syntax Score of the 52 (44.8%) patients was more than 23, and less than 23 in 64 (55.2%) of the cases. The Syntax Score II for the same patients recommended only CABG in 13 (11.2%), only PCI - in 6 (5.2%) and equality between methods - in 97 (83.6%) cases. Only in 6 (5.2%) patients, there was complete agreement between the risk scales, and for 53 (45.7%) of them, the methods were equal. For 44 (37.9%) patients, the Syntax score recommended CABG (Syntax score more than 23), and Syntax Score II indicated equality of methods. In 2 (1.7%) patients with a SYNTAX score of more than 23 the Syntax Score II nevertheless recommended PCI. The “heart team” decision and the Syntax Score II recommendation were in agreement in 103 (88.8%) of the cases, while the “heart team” decision and the SYNTAX recommendation were in agreement only in 64 (55.2%) of the cases. At the hospital stage, there were 2 (1.7%) cases of stent thrombosis with a fatal outcome, both in patients with SYNTAX score 42 and 28. To determine the degree of consistency between the risk scales, the Kappa Cohen coefficient was calculated, which was 0.06 (p=0.93), which indicates lack of consistency between SYNTAX and Syntax Score II in recommendations. Conclusion The Syntax Score II risk scale is an effective tool for making “heart team” decisions about myocardial revascularization method and expands indications for performing PCI, and in 88.8% of cases with multi-vessel coronary arteries lesion, it is possible to get equal predictions between the methods of revascularization. In 40% of cases in patients with a SYNTAX of more than 23 Syntax Score II determines an equiprobable prognosis for performing PCI and CABG.


2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
M Ostojic ◽  
N Arnautovic ◽  
D Nezic ◽  
M Borzanovic ◽  
T Ragus ◽  
...  

Abstract Background Controversies exist how to predict medium term mortality (Mt) in diabetics (DM) with 3 vessel (3VD) and/or left main (LM) disease undergoing myocardial revascularization ranging from Syntax Score II (SSII) where DM was not predicative variable up to FREEDOM formula which was derived, just from population with DM (without LM), having DM patients (Pts) requirement of insulin as one of predicative variable. Purpose To compare predicative power of SSII, FREEDOM and formula developed in our institution in Pts post first isolated CABG with 3VD and/or LM with DM. Methods From our prospective data base of 2455 consecutive pts who had the first isolated CABG in the period 01/2012–12/2014 with complex Ischemic Heart Disease with 100% follow up of 4 years all-cause Mt we created by random sampling Training (1321; Mt:10.4%; DM 511; Mt:13.3%) and Validation (1134; Mt:10.0%; DM 414; Mt: 11.8%) sets. After deriving predicative formula (Cox regression) from training population we validated FREEDOM, SSII and Our Formula in 414 pts with DM from the Validation set. Results Characteristics of pts, our formula, predicating power by C Statistics, Calibration plots and Brier scores are presented in Picture 1. Conclusions FREEDOM formula designed just for DM pts with complex Ischemic Heart Disease without LM had the smallest standard error in the estimate, but moderate C statistics as Syntax Score II and our formula which may be used for pts with and without DM and 3VD and/or LM. Picture 1 Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): Ministry of education, science and technology development, Republic of Serbia


2017 ◽  
Vol 30 (4) ◽  
pp. 805-811
Author(s):  
Bruna Corrêa ◽  
Dannuey Machado Cardoso

Abstract Introduction: Cardiovascular diseases are a serious public health problem in Brazil. Myocardial revascularization surgery (MRS) as well as cardiac valve replacement and repair are procedures indicated to treat them. Thus, extracorporeal circulation (ECC) is still widely used in these surgeries, in which patients with long ECC times may have greater neurological deficits. Neurological damage resulting from MRS can have devastating consequences such as loss of independence and worsening of quality of life. Objective: To assess the effect of cardiac surgery on a patient’s mental state and functional capacity in both the pre- and postoperative periods. Methods: We conducted a cross-sectional study with convenience sampling of subjects undergoing MRS and valve replacement. Participants were administered the Mini-Mental State Exam (MMSE) and the Duke Activity Status Index (DASI) in the pre- and postoperative periods, as well as before their hospital discharge. Results: This study assessed nine patients (eight males) aged 62.4 ± 6.3 years with a BMI of 29.5 ± 2.3 kg/m2. There was a significant decrease in DASI scores and VO2 from preoperative to postoperative status (p = 0.003 and p = 0.003, respectively). Conclusion: This study revealed a loss of cognitive and exercise capacity after cardiac surgery. A larger sample however is needed to consolidate these findings.


Cor et Vasa ◽  
2021 ◽  
Vol 63 (5) ◽  
pp. 572-578
Author(s):  
Hazar Harbalioğlu ◽  
Ömer Genç ◽  
Alaa Quisi ◽  
Abdullah Yildirim ◽  
İbrahim Halil Kurt

2021 ◽  
Vol 78 (12) ◽  
pp. 1227-1238 ◽  
Author(s):  
Hironori Hara ◽  
Hiroki Shiomi ◽  
David van Klaveren ◽  
David M. Kent ◽  
Ewout W. Steyerberg ◽  
...  

ESC CardioMed ◽  
2018 ◽  
pp. 2659-2663
Author(s):  
Fabio Rigamonti ◽  
Marco Roffi

An individualized, stepwise patient evaluation based on the degree of urgency of non-cardiac surgery, functional capacity, clinical presentation, and estimated cardiovascular stress related to surgery is recommended in order to assess the perioperative cardiovascular risk and optimize management. Myocardial ischaemia in the context of non-cardiac surgery may be related to acute coronary syndromes secondary to coronary plaque rupture or prolonged myocardial oxygen supply–demand imbalance. Randomized controlled trials have failed to show a benefit of routine preoperative prophylactic myocardial revascularization. Preoperative coronary angiography and, if appropriate, myocardial revascularization may be considered before high-risk surgery depending on symptom status and extent of ischaemia on non-invasive imaging. In patients requiring percutaneous coronary intervention, guidelines recommend new-generation drug-eluting stents over bare-metal stents, though randomized data are absent. While the minimal delay for a safe surgery following drug-eluting stent implantation remains to be defined, a time window of 5–6 weeks between percutaneous coronary intervention and surgery appears to be adequate in patients who cannot wait longer.


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