Role of Exercise-Induced Repetitive Rise of Filling Pressure and Plasma Hormones for Advanced Progressive Remodeling - Effect of Quinapril

SummaryThe effect of strenuous exercise on the fibrinolytic and coagulation mechanisms was examined in six healthy male subjects. Five min bicycle exercise at a work-rate of 800 to 1200 kpm. min−1 produced an abrupt increase in plasma plasminogen activator levels which disappeared after 90 min. However, there was no change in early or late fibrin degradation products nor was there a change in fibrinopeptide A levels or βthromboglobulin levels after exercise although activated partial thromboplastin times were significantly shortened. It is concluded that strenuous exercise does not produce any real increase in fibrinogen-fibrin conversion nor any real increase in the breakdown of these proteins. The role of exercise-induced release of plasminogen activator remains unclear, but probably helps to maintain plasma levels in a discontinuous manner concurrently with the continuous low-level secretion from the vascular wall. The shortening of partial thromboplastin time may be due to the raised levels of plasminogen activator changing the activation state of other coagulation factors.

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Role of the sympathoadrenal system in exercise-induced inhibition of insulin secretion. Effects of islet transplantation

Diabetes ◽

10.2337/diabetes.44.5.565 ◽

1995 ◽

Vol 44 (5) ◽

pp. 565-571 ◽

Cited By ~ 7

Author(s):

H. Houwing ◽

K. M. Frankel ◽

J. H. Strubbe ◽

P. T. van Suylichem ◽

A. B. Steffens

Keyword(s):

Insulin Secretion ◽

Islet Transplantation ◽

Sympathoadrenal System ◽

Exercise Induced

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From Exercise to Cognitive Performance: Role of Irisin

Applied Sciences ◽

10.3390/app11157120 ◽

2021 ◽

Vol 11 (15) ◽

pp. 7120

Author(s):

Mirko Pesce ◽

Irene La Fratta ◽

Teresa Paolucci ◽

Alfredo Grilli ◽

Antonia Patruno ◽

...

Keyword(s):

The Elderly ◽

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor ◽

Beneficial Effects ◽

General Exercise ◽

Fibronectin Type Iii ◽

Exercise Induced ◽

Fibronectin Type Iii Domain ◽

The Brain

The beneficial effects of exercise on the brain are well known. In general, exercise offers an effective way to improve cognitive function in all ages, particularly in the elderly, who are considered the most vulnerable to neurodegenerative disorders. In this regard, myokines, hormones secreted by muscle in response to exercise, have recently gained attention as beneficial mediators. Irisin is a novel exercise-induced myokine, that modulates several bodily processes, such as glucose homeostasis, and reduces systemic inflammation. Irisin is cleaved from fibronectin type III domain containing 5 (FNDC5), a transmembrane precursor protein expressed in muscle under the control of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). The FNDC5/irisin system is also expressed in the hippocampus, where it stimulates the expression of the neurotrophin brain-derived neurotrophic factor in this area that is associated with learning and memory. In this review, we aimed to discuss the role of irisin as a key mediator of the beneficial effects of exercise on synaptic plasticity and memory in the elderly, suggesting its roles within the main promoters of the beneficial effects of exercise on the brain.

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Role of Adverse Reactions to Food in Urticaria and Exercise-Induced Anaphylaxis

International Archives of Allergy and Immunology ◽

10.1159/000065181 ◽

2002 ◽

Vol 129 (1) ◽

pp. 19-26 ◽

Cited By ~ 22

Author(s):

Sie-Uen Chong ◽

Margitta Worm ◽

Torsten Zuberbier

Keyword(s):

Adverse Reactions ◽

Exercise Induced

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Role of Ingested Amino Acids and Protein in the Promotion of Resistance Exercise–Induced Muscle Protein Anabolism

Journal of Nutrition ◽

10.3945/jn.114.203208 ◽

2016 ◽

Vol 146 (2) ◽

pp. 155-183 ◽

Cited By ~ 58

Author(s):

Paul T Reidy ◽

Blake B Rasmussen

Keyword(s):

Amino Acids ◽

Resistance Exercise ◽

Muscle Protein ◽

Exercise Induced

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Role of respiratory heat exchange in production of exercise-induced asthma

Journal of Applied Physiology ◽

10.1152/jappl.1979.46.3.467 ◽

1979 ◽

Vol 46 (3) ◽

pp. 467-475 ◽

Cited By ~ 235

Author(s):

E. C. Deal ◽

E. R. McFadden ◽

R. H. Ingram ◽

R. H. Strauss ◽

J. J. Jaeger

Keyword(s):

Heat Exchange ◽

Thermal Load ◽

Tracheobronchial Tree ◽

Total Heat Flux ◽

Random Fashion ◽

Theoretical Predictions ◽

Per Se ◽

Exercise Induced ◽

Respiratory Heat Exchange

We have hypothesized that it is the total heat flux in the tracheobronchial tree during exercise that determines the degree of postexertional obstruction in asthma, and have developed quanititative expressions that relate these two events. We tested this hypothesis by comparing the observed responses to exercise, while our subjects inhaled dry air at various temperatures ranging from subzero to 80 degrees C in a random fashion, to those that we predicted would occur based upon calculations of respiratory heat exchange. We further determined if heat could be transferred from the inspired air to the mucosa so as to offset evaporative losses from the airways. The observed responses fell as air temperature was increased from -11 to +37 degrees C and exactly matched theoretical predictions. Above 37 degrees C, the observed response exceeded predictions, indicating that it was not possible to provide sufficient heat per se in the air to offset the vaporization of water. However, when small amounts of water vapor were added to the inspirate at high temperatures, bronchospasm was virtually abolished and the response again closely matched theoretical expectations. We conclude that the magnitude of exercise-induced asthma is directly proportional to the thermal load placed on the airways and that this reaction is quantifiable in terms of respiratory heat exchange.

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