Queueing-Inventory with One Essential and m Optional Items with Environment Change Process Forming Correlated Renewal Process (MEP)

We consider a queueing inventory with one essential and m optional items for sale. The system evolves in environments that change randomly. There are n environments that appear in a random fashion governed by a Marked Markovian Environment change process. Customers demand the main item plus none, one, or more of the optional items, but were restricted to at most one unit of each optional item. Service time of the main item is phase type distributed and that of optional items have exponential distributions with parameters that depend on the type of the item, as well as the environment under consideration. If the essential item is not available, service will not be provided. The lead times of optional and main items have exponential distributions having parameters that depend on the type of the item. The condition for stability of the system is analyzed by considering a multi-dimensional continuous time Markov chain that represent the evolution of the system. Under this condition, various performance characteristics of the system are derived. In terms of these, a cost function is constructed and optimal control policies of the different types of commodities are investigated. Numerical results are provided to give a glimpse of the system performance.

Computationally defined and in vitro validated putative genomic safe harbour loci for transgene expression in human cells

Stable expression of transgenes is essential in both therapeutic and research applications. Traditionally, transgene integration has been accomplished via viral vectors in a semi-random fashion, but with inherent integration site biases linked to the type of virus used. The randomly integrated transgenes may undergo silencing and more concerningly, can also lead to dysregulation of endogenous genes. Gene dysregulation can lead to malignant transformation of cells and has unfortunately given rise to cases of leukaemia in gene therapy trials. Genomic safe harbour (GSH) loci have been proposed as safe sites for transgene integration. To date, a number of sites in the human genome have been used for directed integration; however none of these pass scrutiny as bona fide GSH. Here, we conducted a computational analysis to identify 25 putative GSH loci that reside in active chromosomal compartments. We validated stable transgene expression in three GSH sites in vitro using human embryonic stem cells (hESCs) and their differentiated progeny. Furthermore, for easy targeted transgene expression, we have engineered constitutive landing pad expression constructs into the three validated GSH in hESCs.

The Effect of the SAMR Model on Acquiring Teaching Skills for Students of Colleges of Education in the Subject of Teaching Applications

This research aims to identify the impact of the model (SAMR) in acquiring teaching skills among students of the colleges of education in the subject of teaching applications. The research sample consisted of (50) students selected from the department of educational and psychological sciences in the College of Education Ibn Rushd For the academic year (2020-2021). This was then divided in a simple random fashion into two groups: the first group (experimental group) included (25) students trained in scientific education lessons according to the teaching program prepared for it while the second group (control group) included (25) students. The researchers conducted the process of balance between the two groups in a number of variables to achieve a goal and choose its hypotheses. After collecting, analysing and processing data statistically using the statistical package (SPSS) and performing t-test on two independent samples and the equation of the ETA box to measure the size of the effect, we obtained the following results: There is no statistically significant difference at the level of significance (0.5) between the average grades of students of the experimental group and the control group in acquiring teaching skills for the experimental group. In light of the findings, the researchers reached several conclusions and presented several recommendations and suggested several future studies.

Numerical investigation of the wake bi-stability behind a notchback Ahmed body

Large-eddy simulations are used to investigate the origin of the wake asymmetry and symmetry behind notchback Ahmed bodies. Two different effective backlight angles, ${\beta _1} = 17.8\mathrm{^\circ }$ and ${\beta _2} = 21.0\mathrm{^\circ }$ , are simulated resulting in wake asymmetry and symmetry in flows without external perturbations, in agreement with previous experimental observations. In particular, the asymmetric case presents a bi-stable nature showing, in a random fashion, two stable mirrored states characterized by a left or right asymmetry for long periods. A random switch and several attempts to switch between the bi-stability are observed. The asymmetry of the flow is ascribed to the asymmetric separations and reattachments in the wake. The deflection of the near-wall flow structures behind the slant counteracting the asymmetry drives the wake to be temporarily symmetric, triggering the switching process of the bi-stable wake. The consequence of deflection that forces the flow structure to form on the opposite side of the slant is the decisive factor for a successful switch. Modal analysis applying proper orthogonal decomposition is used for the exploration of the wake dynamics of the bi-stable nature observed.

How small-scale variation in mineral wool products effect random incidence sound absorption

Mineral wool products are produced by creating a spray of fibres, that is collected and made into slabs. This randomized spray can lead to small variations across a slab. Nevertheless, mineral wool slabs are often treated in acoustics as locally reacting perfectly homogeneous, isotropic materials. This means that small-scale characterisations are extrapolated to large-scale without considering the impact from possible variations in a large-scale setup. The question is how the small-scale characterisations should be used for large-scale setups with this in mind. Three products with the same thickness and density, but with significantly different specific airflow resistances were selected for random incidence sound absorption tests. The products were all specially made ceiling tiles and measurements were conducted in E200 setup according to ISO 354:2003. The tiles were gradually exchanged in a random fashion, so measurement results were obtained using a combination of tiles with different specific airflow resistances. Results showed a surprisingly linear relation between the sound absorption and the average specific airflow resistance of tiles used in the measurements. The results point to that variations in products must be observed, but also that small variations in specific airflow resistance in standardized products are insignificant.

Increasing Transparency and Feasibility of Auto Accessibility for Project Prioritization

Accessibility, the number of time-decayed jobs available to each zone within a region, can help prioritize candidate transportation investments. This paper demonstrates how to compute auto accessibility using commonly available resources and identifies strategies needed to render calculations feasible and transparent. (The scope excludes transit and pedestrian impacts.) For the first objective, computational solutions included developing a semi-automated method to import legacy transportation networks, automating turn prohibitions, and using an algorithm to check for inconsistently formed service areas that sometimes occur in a random fashion with geographic information system software. Failure to exercise quality control using these approaches gives erroneous results: not solving the problem of inconsistently formed service areas led to a region within 50 mi of a 1-mi corridor (where improvements are proposed) having an accessibility almost 40 times higher than the correct value. For the second objective, the influence area (i.e., catchment radius) mattered most: for one project, the forecast accessibility improvement dropped by 80% when an area within 45 mi of the project, rather than an area within 15 mi, was the basis of the analysis. Other decisions affected forecast accessibility improvement less: the choice of the number of centroid connectors affected forecasts by an average of 23% (with a 10-mi influence area). Choosing to eliminate negative net accessibility contributions, attributed to geometric approximations in the software, affected forecasts by less than 21% (35-mi influence area or smaller). Ranking five proposed investments in relation to their forecast accessibility benefit demonstrated the importance of documenting users’ computational choices.

Mechanics of Biohybrid Valveless Pump-bot

Engineering living systems is a rapidly emerging discipline where the functional biohybrid robotics (or ‘Bio-bots’) are built by integrating of living cells with engineered scaffolds. Inspired by embryonic heart, we presented earlier the first example of a biohybrid valveless pump-bot, an impedance pump, capable of transporting fluids powered by engineered living muscle tissues. The pump consists of a soft tube attached to rigid boundaries at the ends, and a muscle ring that squeezes the tube cyclically at an off-center location. Cyclic contraction results in a net flow through the tube. We observed that muscle force occasionally buckles the tube in a random fashion, i.e., similar muscles do not buckle the tube consistently. In order to explain this anomaly, here we develop an analytical model to predict the deformation and stability of circular elastic tubes subjected to a uniform squeezing force due to a muscle ring (like a taught rubber band). The prediction from the model is validated by comparing with experiments and finite element analysis. The non-linear model reveals that the circular elastic tube cannot buckle irrespective of muscle force. Buckling state can be reached and sustained by bending and folding the tube before applying the muscle ring. This imperfection may appear during assembly of the pump or from non-uniform thickness of the muscle ring. This study provides design guides for developing advanced biohybrid impedance pumps for diverse applications.

A new speech encryption algorithm based on dual shuffling Hénon chaotic map

Over the past few decades, many algorithms have been proposed to improve the performance of speech encryption over un-secure channel (i.e., Internet). In this paper, the security level was enhanced using a dynamic dual chaotic based on Hénon chaotic map. In the proposed algorithm, the speech elements are shuffled in a random fashion. Moreover, when both Hénon state variables are free to be used for shuffling the index is toggled randomly between them according to toggle bit. After index shuffling each speech element is modified with XOR operation between the original speech element value and the key that is selected randomly from the updated key table. The same chaotic map is used to initiate the empty or full table and provide new table entries from the values that are already shuffled. The experimental results show that the proposed crypto-system is simple, fast with extra random toggling behavior. The high order of substitution make it sensitive to initial condition, common cryptanalysis attacks such as linear and differential attacks are infeasible.

Antimicrobial Resistance as a Creeping Crisis

Antimicrobial resistance (AMR) displays many of the characteristics of a creeping crisis. It lacks clearly definable temporal and spatial boundaries. It develops in the natural world when and where conditions are conducive. It traverses sectors and borders in the natural, human, and built environments. It causes individual and societal harm when it escalates toward outbreaks in a random fashion. Outbreaks can be minor or major, burn fast or slow, be simple or hard to contain. Experts insist we are heading toward a “post-antibiotic age” and even deadlier “superbugs” if we do not act. Yet warnings and crisis framings do not appear sufficient to prompt a response. Public attention and governmental action have lagged. Occasional outbreaks invite attention and concern, only for the issue to fade again from the public view. International organizations shine more sustained light on the problem, but national governments are slow to respond. This chapter argues that our dependency on antimicrobial drugs is a blessing and a curse: curing us in the short term but building the conditions for a massive, incurable outbreak in the future.

Study on South Asian Diabetic Subjects on Different Attributes

Diabetes is a serious problem in today's world. Stress TTH (tension type headache) is another epidemic which is growing with a very fast pace. Diabetes is a disease of the body that prevents the metabolism of blood sugar (glucose). This increases the blood glucose to a risky level. The present study aims to analyze diabetes with the latest IoT and big data analysis techniques and its correlation with stress (TTH) on human health. Authors have tried to include age, gender, and insulin factor and its correlation with diabetes. IoT helps us to connect each other, that is, it is known a smart connecting thing (a sort of “universal global neural network” in cloud). It comprises of smart connecting machine with other machine, object, and a lot more. Big data refers to huge sets of data that are also large enough in terms of variety and velocity. Due to this, it becomes more difficult to handle, organise, store, process, and manipulate such data using traditional techniques of storage and processing. Stress especially TTH (tension type headache) is a serious problem in today's world. Now every person in this world is facing headache and stress-related problems in daily life. The authors have collected this big data and studied the people; they have studied their tension level and helped them to cure it. In this chapter, they analyze the correlation between diabetes and stressors. For the analysis, they collected sample of 30 subjects from hospitals of Delhi in random fashion who have been suffering from diabetes from their health insurance providers without disclosing any personal information (PI) or sensitive personal information (SPI) by law. To identify each case sample IDs like S1, S2, etc. has been allotted to the subjects. Sample data has been collected for following parameters: gender, age, diabetes type, insulin dependency, obesity status, CAD status, and CAN status. They have used the Tableau s/w for this analysis. Overall, an interesting observation during the research was that none of the female subjects having diabetes is below 25 years, that is, early age diabetes cases are less comparative to males subjected to the case sampling should not be impacted for age group gender biasing.