Social functioning, psychopathology, and medication side effects in relation to substance use and abuse in schizophrenia

2001 ◽  
Vol 48 (1) ◽  
pp. 109-123 ◽  
Author(s):  
Michelle P Salyers ◽  
Kim T Mueser
2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Etsedingl Hadera ◽  
Endalamaw Salelew ◽  
Eshetu Girma ◽  
Sandra Dehning ◽  
Kristina Adorjan ◽  
...  

Background. Many people with mental illness perceive and experience stigma caused by other people’s knowledge, attitudes, and behavior. The stigma can lead to patients’ impoverishment, social marginalization, poor adherence to medication, and low quality of life, worsen the disease, decrease health-seeking behavior, and have a negative impact on socioeconomic well-being. Therefore, this study aimed to explore these issues. Objective. To assess the magnitude and associated factors of perceived stigma among adults with mental illness in an Ethiopian setting. Methods. A facility-based, cross-sectional study design with a consecutive sampling technique was employed from September 1 to 30, 2012. Data for perceived stigma were assessed by using the perceived devaluation-discrimination (PDD) scale from new or returning patients. The data was analyzed by using the Statistical Package for the Social Sciences (SPSS) version 20. The results were described with the frequency table, graph, mean, and standard deviation. Bivariate analysis was used to get candidate variables for multivariate logistic regression analysis. Variables with a P value of < 0.05 at multivariate analysis were considered statistically associated with perceived stigma. Results. A total of 384 participants were interviewed and the response rate was 100%. The prevalence of high and low perceived stigma was 51% and 44%, respectively. Having substance use history (AOR=0.6, 95% CI: 0.4–0.9) and family support (AOR=2.5, 95% CI: 1.5–4.3) and medication side effects (AOR=0.6, 95% CI: 0.5–0.8) were associated statistically with higher perceived stigma of people with mental illness. Conclusion. Perceived stigma is a major problem of adults with mental illness in this outpatient setting in Ethiopia. Patients who had substance use and family support and medication side effects were more likely to have high perceived stigma. Therefore, screening and management of substance use, social support, and medication side effect should be strengthened for people with mental illness.


BMJ ◽  
2010 ◽  
Vol 341 (sep15 2) ◽  
pp. c4999-c4999

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Claire J. Wiggins ◽  
Susan Y. Chon

As aberrant Notch signaling has been linked to cancerous growth, Notch inhibitors represent a novel category of targeted oncological therapy. Notch pathways in tumor cells may contribute to proliferation or limit apoptosis and differentiation. Healthy skin differentiation and homeostasis are reliant on normal Notch expression, and disruption of this signaling has been implicated in dermatological conditions such as hidradenitis suppurativa, psoriasis, atopic dermatitis, and lichen planus. Here, we describe two cases of patients with cutaneous side effects from Notch inhibitor treatment for adenoid cyst carcinoma (ACC) and review the role of Notch signaling in skin disease. By illuminating connections between medication side effects and disease pathogenesis, our goal is to increase awareness of the cutaneous side effects of Notch inhibitor treatment.


2011 ◽  
Vol 24 (1) ◽  
pp. 159-169 ◽  
Author(s):  
Waleed Fawzi ◽  
Mohamed Yousry Abdel Mohsen ◽  
Abdel Hamid Hashem ◽  
Suaad Moussa ◽  
Elizabeth Coker ◽  
...  

ABSTRACTBackground: Adherence to treatment is a complex and poorly understood phenomenon. This study investigates the relationship between older depressed patients’ adherence to antidepressants and their beliefs about and knowledge of the medication.Methods: Assessment was undertaken of 108 outpatients over the age of 55 years diagnosed with depressive disorder and treated for at least four weeks with antidepressants. Adherence was assessed using two self-report measures: the Medication Adherence Rating Scale (MARS) and a Global Adherence Measure (GAM). Potential predictors of adherence investigated included sociodemographic, medication and illness variables. In addition, 33 carers were interviewed regarding general medication beliefs.Results: 56% of patients reported 80% or higher adherence on the GAM. Sociodemographic variables were not associated with adherence on the MARS. Specific beliefs about medicines, such as “my health depends on antidepressants” (necessity) and being less worried about becoming dependant on antidepressants (concern) were highly correlated with adherence. General beliefs about medicines causing harm or being overprescribed, experiencing medication side-effects and severity of depression also correlated with poor adherence. Linear regression with the MARS as the dependent variable explained 44.3% of the variance and showed adherence to be higher in subjects with healthy specific beliefs who received more information about antidepressants and worse with depression severity and autonomic side-effects.Conclusions: Our findings strongly support a role for specific beliefs about medicines in adherence. Challenging patients’ beliefs, providing information about treatment and discussing side-effects could improve adherence. Poor response to treatment and medication side-effects can indicate poor adherence and should be considered before switching medications.


2018 ◽  
Vol 192 ◽  
pp. 211-212 ◽  
Author(s):  
Martina Rojnic Kuzman ◽  
Olivier Andlauer ◽  
Kai Burmeister ◽  
Boris Dvoracek ◽  
Rebekka Lencer ◽  
...  

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