P.1.e.028 Increase of whole brain volume and gray and white matter tissue in OCD: a volumetric and voxel-based morphometry MRI study

2010 ◽  
Vol 20 ◽  
pp. S303-S304
Author(s):  
T. Sobanski ◽  
G. Wagner ◽  
G. Peikert ◽  
U. Gruhn ◽  
H. Sauer ◽  
...  
Keyword(s):  
White Matter ◽  
Brain Volume ◽  
Voxel Based Morphometry ◽  
Whole Brain ◽  
Mri Study

scholarly journals Pervasive White Matter Fiber Degeneration in Ischemic Stroke

Stroke ◽  
2020 ◽  
Vol 51 (5) ◽  
pp. 1507-1513 ◽  
Author(s):  
Natalia Egorova ◽  
Thijs Dhollander ◽  
Mohamed Salah Khlif ◽  
Wasim Khan ◽  
Emilio Werden ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
White Matter ◽  
Cross Section ◽  
Corticospinal Tract ◽  
Brain Volume ◽  
Morphological Changes ◽  
Axonal Loss ◽  
Fiber Density ◽  
Whole Brain ◽  
Brain Volume Loss

Background and Purpose— We examined if ischemic stroke is associated with white matter degeneration predominantly confined to the ipsi-lesional tracts or with widespread bilateral axonal loss independent of lesion laterality. Methods— We applied a novel fixel-based analysis, sensitive to fiber tract–specific differences within a voxel, to assess axonal loss in stroke (N=104, 32 women) compared to control participants (N=40, 15 women) across the whole brain. We studied microstructural differences in fiber density and macrostructural (morphological) changes in fiber cross-section. Results— In participants with stroke, we observed significantly lower fiber density and cross-section in areas adjacent, or connected, to the lesions (eg, ipsi-lesional corticospinal tract). In addition, the changes extended beyond directly connected tracts, independent of the lesion laterality (eg, corpus callosum, bilateral inferior fronto-occipital fasciculus, right superior longitudinal fasciculus). Conclusions— We conclude that ischemic stroke is associated with extensive neurodegeneration that significantly affects white matter integrity across the whole brain. These findings expand our understanding of the mechanisms of brain volume loss and delayed cognitive decline in stroke.

Hippocampal atrophy, whole brain volume, and white matter lesions in older hypertensive subjects

Neurology ◽  
2004 ◽  
Vol 63 (10) ◽  
pp. 1892-1897 ◽  
Author(s):  
R. M. Wiseman ◽  
B. K. Saxby ◽  
E. J. Burton ◽  
R. Barber ◽  
G. A. Ford ◽  
...  
Keyword(s):  
White Matter ◽  
Brain Volume ◽  
White Matter Lesions ◽  
Hippocampal Atrophy ◽  
Whole Brain

Whole-brain voxel-based morphometry of white matter in medial temporal lobe epilepsy

2008 ◽  
Vol 65 (1) ◽  
pp. 86-90 ◽  
Author(s):  
Aihong Yu ◽  
Kuncheng Li ◽  
Lin Li ◽  
Baoci Shan ◽  
Yuping Wang ◽  
...  
Keyword(s):  
White Matter ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Voxel Based Morphometry ◽  
Whole Brain ◽  
Medial Temporal Lobe Epilepsy

Correlation of white matter integrity and autism clinical symptomatology: A whole-brain diffusion MRI study

2012 ◽  
Vol 60 (5) ◽  
pp. S197
Author(s):  
A. Bargiacchi ◽  
A. Cachia ◽  
L. Lemaitre ◽  
N. Chabane ◽  
N. Boddaert ◽  
...  
Keyword(s):  
White Matter ◽  
Diffusion Mri ◽  
White Matter Integrity ◽  
Whole Brain ◽  
Clinical Symptomatology ◽  
Mri Study

scholarly journals Fluctuating Asymmetry and Individual Variation in Regional Gray and White Matter Volumes: A Voxel-Based Morphometry Study

2008 ◽  
Vol 6 (4) ◽  
pp. 147470490800600 ◽  
Author(s):  
Matthew Euler ◽  
Robert J. Thoma ◽  
Lauren Parks ◽  
Steven W. Gangestad ◽  
Ronald A. Yeo
Keyword(s):  
White Matter ◽  
Fluctuating Asymmetry ◽  
Gray Matter Volume ◽  
Brain Mri ◽  
Brain Regions ◽  
Voxel Based Morphometry ◽  
Whole Brain ◽  
Matter Volume ◽  
Brain White Matter ◽  
Mri Scans

Composite measures of fluctuating asymmetry (FA) of skeletal features are commonly used to estimate developmental instability (DI), the imprecise expression of developmental design due to perturbations during an individual's growth and maturation. Though many studies have detailed important behavioral correlates of FA, very little is known about its possible neuroanatomical correlates. In this study we obtained structural brain MRI scans from 20 adults and utilized voxel-based morphometry (VBM) to identify specific regions linked to FA. Greater FA predicted greater whole brain white matter volume, and a trend in the same direction was noted for whole brain gray matter volume. Greater FA was associated with significantly greater gray and white matter volumes in discrete brain regions, most prominently in the frontal lobes and in the right cerebral hemisphere. Developmental studies are needed to identify when FA-related brain differences emerge and to elucidate the specific neurobiological mechanisms leading to these differences.

Reduced gray matter volume in patients with retinal detachment: evidence from a voxel-based morphometry study

2019 ◽  
Vol 61 (3) ◽  
pp. 395-403
Author(s):  
Biao Li ◽  
Yu-Xin Liu ◽  
Hai-Jun Li ◽  
Qing Yuan ◽  
Pei-Wen Zhu ◽  
...  
Keyword(s):  
White Matter ◽  
Retinal Detachment ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Cingulate Gyrus ◽  
Voxel Based Morphometry ◽  
White Matter Volume ◽  
Whole Brain ◽  
Matter Volume ◽  
Brain White Matter

Background We know little about the pathogenesis and diagnosis of retinal detachment. Purpose To assess spontaneous changes in the cerebral cortex of patients with retinal detachment using voxel-based morphometry and to explore the relationship between retinal detachment and clinical behavioral performance. Material and Methods Patients (14 men, 6 women; average age = 49.15 ± 10.32 years) with rhegmatogenous retinal detachment (duration of 24.05 ± 19.61 days) and 20 matched healthy controls were recruited. All participants underwent repeated functional magnetic resonance imaging scans. The original three-dimensional T1 brain images were analyzed using voxel-based morphometry and whole brain white matter volume and whole brain gray matter volume were compared with those of the control group. A receiver operating characteristic (ROC) curve was used to classify the mean gray matter volume values of the patients with retinal detachment compared with the controls. Results Compared with the controls, whole brain gray matter volume was significantly reduced in patients with retinal detachment, as evidenced by changes in the right inferior frontal gyrus, right superior temporal gyrus, right anterior cingulate gyrus, and right cuneus. In addition, the posterior lobe of the cerebellum, left hippocampus, left cingulate gyrus, and left middle temporal gyrus were also obviously atrophied. Furthermore, whole brain white matter volume of the patients with retinal detachment showed a slight reduction. The ROC curve analysis of each brain region showed that the accuracy of the area under the curve was high. Conclusion We proved that patients with retinal detachment had unusual changes in the gray matter volume and white matter volume in vision-related brain regions, which could reveal potential pathological mechanisms of retinal detachment.

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