Effective electroconvulsive therapy reverses glutamate/glutamine deficit in the left anterior cingulum of unipolar depressed patients

2003 ◽  
Vol 122 (3) ◽  
pp. 185-192 ◽  
Author(s):  
Bettina Pfleiderer ◽  
Nikolaus Michael ◽  
Andreas Erfurth ◽  
Patricia Ohrmann ◽  
Ulrike Hohmann ◽  
...  
Keyword(s):  
Electroconvulsive Therapy ◽  
Depressed Patients

scholarly journals Methylome-wide change associated with response to electroconvulsive therapy in depressed patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lea Sirignano ◽  
Josef Frank ◽  
Laura Kranaster ◽  
Stephanie H. Witt ◽  
Fabian Streit ◽  
...  
Keyword(s):  
Electroconvulsive Therapy ◽  
Rating Scale ◽  
Antidepressant Treatment ◽  
Cpg Sites ◽  
Cpg Site ◽  
Depressed Patients ◽  
Resistant Depression ◽  
Functional Pathway ◽  
Regional Analyses ◽  
The Relationship

AbstractElectroconvulsive therapy (ECT) is a quick-acting and powerful antidepressant treatment considered to be effective in treating severe and pharmacotherapy-resistant forms of depression. Recent studies have suggested that epigenetic mechanisms can mediate treatment response and investigations about the relationship between the effects of ECT and DNA methylation have so far largely taken candidate approaches. In the present study, we examined the effects of ECT on the methylome associated with response in depressed patients (n = 34), testing for differentially methylated CpG sites before the first and after the last ECT treatment. We identified one differentially methylated CpG site associated with the effect of ECT response (defined as >50% decrease in Hamilton Depression Rating Scale score, HDRS), TNKS (q < 0.05; p = 7.15 × 10−8). When defining response continuously (ΔHDRS), the top suggestive differentially methylated CpG site was in FKBP5 (p = 3.94 × 10−7). Regional analyses identified two differentially methylated regions on chromosomes 8 (Šídák’s p = 0.0031) and 20 (Šídák’s p = 4.2 × 10−5) associated with ΔHDRS. Functional pathway analysis did not identify any significant pathways. A confirmatory look at candidates previously proposed to be involved in ECT mechanisms found CpG sites associated with response only at the nominally significant level (p < 0.05). Despite the limited sample size, the present study was able to identify epigenetic change associated with ECT response suggesting that this approach, especially when involving larger samples, has the potential to inform the study of mechanisms involved in ECT and severe and treatment-resistant depression.

Electroconvulsive therapy induced gray matter increase is not necessarily correlated with clinical data in depressed patients

2019 ◽  
Vol 12 (2) ◽  
pp. 335-343 ◽  
Author(s):  
Alexander Sartorius ◽  
Traute Demirakca ◽  
Andreas Böhringer ◽  
Christian Clemm von Hohenberg ◽  
Suna Su Aksay ◽  
...  
Keyword(s):  
Clinical Data ◽  
Electroconvulsive Therapy ◽  
Gray Matter ◽  
Depressed Patients

scholarly journals Electroconvulsive therapy suppresses the neurotoxic branch of the kynurenine pathway in treatment-resistant depressed patients

2016 ◽  
Vol 13 (1) ◽  
Author(s):  
Lilly Schwieler ◽  
Martin Samuelsson ◽  
Mark A. Frye ◽  
Maria Bhat ◽  
Ina Schuppe-Koistinen ◽  
...  
Keyword(s):  
Electroconvulsive Therapy ◽  
Kynurenine Pathway ◽  
Treatment Resistant ◽  
Depressed Patients

Which Depressed Patients will Respond to Electroconvulsive Therapy?

1989 ◽  
Vol 154 (1) ◽  
pp. 8-17 ◽  
Author(s):  
Allan I. F. Scott
Keyword(s):  
Effective Treatment ◽  
Clinical Features ◽  
Electroconvulsive Therapy ◽  
Physiological Responses ◽  
Depressive Illness ◽  
Seizure Threshold ◽  
Posterior Pituitary ◽  
Clinical Predictors ◽  
Depressed Patients ◽  
Wide Range

A small yet significant minority of contemporary patients with endogenous depressive illness who are treated with electroconvulsive therapy (ECT) gain little or no benefit. It is argued that the use of clinical features alone may not improve the ability to predict outcome after ECT. Many biological measures have been used to attempt to identify depressed patients for whom ECT would be an effective treatment, but none has yet been shown to be superior to clinical predictors. Depressed patients show a wide range of physiological responses to the first treatment of a course of ECT. Of these physiological responses, estimations of seizure threshold and of the release of posterior pituitary peptides merit further investigation as putative predictors of recovery.

Inter-individual variability of neurocognitive performances after electroconvulsive therapy in depressed patients: improvement and decline

2017 ◽  
Vol 10 (2) ◽  
pp. 386
Author(s):  
E. Verwijk ◽  
H.P. Spaans ◽  
H.C. Comijs ◽  
R.M. Kok ◽  
K.H. Kho ◽  
...  
Keyword(s):  
Electroconvulsive Therapy ◽  
Individual Variability ◽  
Depressed Patients

Heart rate variability increases in elderly depressed patients who respond to electroconvulsive therapy

2004 ◽  
Vol 56 (1) ◽  
pp. 89-94 ◽  
Author(s):  
Eitan Nahshoni ◽  
Dov Aizenberg ◽  
Mayanit Sigler ◽  
Boris Strasberg ◽  
Gil Zalsman ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Electroconvulsive Therapy ◽  
Depressed Patients

Influence of electroconvulsive therapy on white matter structure in a diffusion tensor imaging study

2019 ◽  
Vol 50 (5) ◽  
pp. 849-856 ◽  
Author(s):  
Jonathan Repple ◽  
Susanne Meinert ◽  
Irene Bollettini ◽  
Dominik Grotegerd ◽  
Ronny Redlich ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Prospective Study ◽  
Electroconvulsive Therapy ◽  
Inpatient Treatment ◽  
Right Hemisphere ◽  
Diffusion Tensor ◽  
Therapy Response ◽  
Seizure Duration ◽  
Depressed Patients

AbstractBackgroundElectroconvulsive therapy (ECT) is a fast-acting intervention for major depressive disorder. Previous studies indicated neurotrophic effects following ECT that might contribute to changes in white matter brain structure. We investigated the influence of ECT in a non-randomized prospective study focusing on white matter changes over time.MethodsTwenty-nine severely depressed patients receiving ECT in addition to inpatient treatment, 69 severely depressed patients with inpatient treatment (NON-ECT) and 52 healthy controls (HC) took part in a non-randomized prospective study. Participants were scanned twice, approximately 6 weeks apart, using diffusion tensor imaging, applying tract-based spatial statistics. Additional correlational analyses were conducted in the ECT subsample to investigate the effects of seizure duration and therapeutic response.ResultsMean diffusivity (MD) increased after ECT in the right hemisphere, which was an ECT-group-specific effect. Seizure duration was associated with decreased fractional anisotropy (FA) following ECT. Longitudinal changes in ECT were not associated with therapy response. However, within the ECT group only, baseline FA was positively and MD negatively associated with post-ECT symptomatology.ConclusionOur data suggest that ECT changes white matter integrity, possibly reflecting increased permeability of the blood–brain barrier, resulting in disturbed communication of fibers. Further, baseline diffusion metrics were associated with therapy response. Coherent fiber structure could be a prerequisite for a generalized seizure and inhibitory brain signaling necessary to successfully inhibit increased seizure activity.

Effect of Electroconvulsive Therapy on Erythrocyte Adenosine Triphosphatase Activity in Depressive Illness

1980 ◽  
Vol 137 (4) ◽  
pp. 343-345 ◽  
Author(s):  
L. J. Whalley ◽  
M. Scott ◽  
H. W. Reading ◽  
J. E. Christie
Keyword(s):  
Atpase Activity ◽  
Erythrocyte Membrane ◽  
Electroconvulsive Therapy ◽  
Healthy Subjects ◽  
Adenosine Triphosphatase ◽  
Depressive Illness ◽  
Slight Reduction ◽  
Acute Effects ◽  
Adenosine Triphosphatase Activity ◽  
Depressed Patients

SummaryErythrocyte membrane adenosine triphosphatase activities were examined in twelve unipolar depressed patients receiving ECT. Eleven patients undergoing diagnostic cystoscopy served as controls for the acute effects of anaesthesia, and sixteen healthy subjects served as non-depressed controls. The unipolar depressed patients had a slight reduction in their (Na++K+)-ATPase activity but effective ECT treatment was not associated with any increase in this activity. This approach is unlikely to cast further light on the membrane phenomenology of depressive illness.

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