Liver copper content of rats hypo- or hyperresponsive to dietary cholesterol

2003 ◽  
Vol 17 (3) ◽  
pp. 177-182
Author(s):  
Ingeborg de Wolf ◽  
Xandra Fielmich-Bouman ◽  
Ægidius Lankhorst ◽  
Bernard van Oost ◽  
Anton Beynen ◽  
...  
Keyword(s):  
Copper Content ◽  
Dietary Cholesterol ◽  
Liver Copper

PA76 CORRELATION BETWEEN URINARY COPPER EXCRETION AND LIVER COPPER CONTENT WITH AGE IN CHILDREN WITH WILSON DISEASE

2010 ◽  
Vol 42 ◽  
pp. S373
Author(s):  
G. Ranucci ◽  
E. Nicastro ◽  
C. Della Corte ◽  
M. Tufano ◽  
P. Vajro ◽  
...  
Keyword(s):  
Wilson Disease ◽  
Copper Content ◽  
Copper Excretion ◽  
Liver Copper ◽  
Urinary Copper ◽  
Urinary Copper Excretion

Supplementation of bacon pig rations by aureomycin and two levels of copper sulphate

1961 ◽  
Vol 3 (1) ◽  
pp. 89-95 ◽  
Author(s):  
D. B. Bellis
Keyword(s):  
Growth Rate ◽  
Copper Sulphate ◽  
Copper Content ◽  
Economic Advantage ◽  
Additional Benefit ◽  
Feeding Period ◽  
Food Conversion ◽  
Liver Copper ◽  
Copper Storage ◽  
Food Conversion Efficiency

A trial has been carried out to determine the effects of supplementing bacon pig diets with 125 and 250 ppm. copper (as copper sulphate) and/or aureomycin (14·4 ppm.). A total of 288 pigs were fed ad lib. from 40·100lb., and restricted-fed thereafter to bacon weight (200 1b.). Growth rate was increased by 125 ppm. copper, 250 ppm. copper, and aureomycin during the ad lib. feeding period. The magnitude of the responses was about the same in each case.During the fattening stage from 100 1b. to bacon weight, 125 ppm. copper or aureomycin increased food conversion efficiency; 250 ppm. copper however improved growth rate also. There was probably some additive effect of 125 ppm. copper and aureomycin when fed together, but it is unlikely that such an effect occurred with the higher level of copper and aureomycin.The liver copper content of pigs fed 125 ppm. copper was 3 times higher than that of the controls; 250 ppm. copper increased liver copper storage about 18·fold.The similarity in response of copper and aureomycin feeding to pigs is discussed. It is concluded that, under the conditions of the trial, their mode of action is similar. Under similar conditions in general farm practice there is unlikely to be any economic advantage in supplementing pig diets containing 250 ppm copper with aureomycin; however, the bacterial environment may sometimes be such that additional benefit will be obtained by joint supplementation.

Liver Attenuation Values at Computed Tomography Related to Liver Copper Content

1982 ◽  
Vol 17 (4) ◽  
pp. 461-463 ◽  
Author(s):  
B. Smevik ◽  
S. Ritland ◽  
T. Nilsen ◽  
O. Johansen
Keyword(s):  
Computed Tomography ◽  
Copper Content ◽  
Liver Copper ◽  
Attenuation Values

A kinetic model of copper metabolism in sheep

1980 ◽  
Vol 31 (4) ◽  
pp. 773 ◽  
Author(s):  
KM Weber ◽  
RC Boston ◽  
DD Leaver
Keyword(s):  
Rate Constants ◽  
Copper Content ◽  
Copper Metabolism ◽  
Normal Liver ◽  
Dry Weight ◽  
Compartment Model ◽  
Flow Rates ◽  
Liver Copper ◽  
Copper Status ◽  
Three Compartment Model

A three-compartment model was developed to provide a simple kinetic description of the metabolism of copper in six sheep with liver copper concentrations of 433�51 ppm ( mean � SD dry weight). This was achieved by measuring the radioactivity in samples of blood, liver, urine and bile as a function of time after the intravenous administration of c. 1.4 mCi of 64Cu. Sizes of compartments, flow rates and rate constants were evaluated and validated experimentally by measuring the excretion of copper in urine and bile and its accumulation in the liver. The model postulates two separate mechanisms for the handling of copper by the liver, and biliary copper excretion was not related to total liver copper content. The model was tested in sheep with a wider range of liver copper concentrations, and the copper in the two compartments (C2 and C3), attributed to liver, corresponded to the actual liver copper content when this was between 30 and 70 mg. The rate constants also responded consistently to increased liver copper status. Within the 'normal' liver copper range of 50-70 mg, the three-compartment model was closed but outside this range, the undefined parameter K03 was no longer zero. This response suggests that copper is moving from C2 and C3 to either supply tissue requirements or be redistributed in an additional storage compartment.

Quantitative Trait Loci Influencing Hepatic Copper in Rats

2002 ◽  
Vol 227 (7) ◽  
pp. 529-534 ◽  
Author(s):  
I.D. de Wolf ◽  
A.C.M. Bonné ◽  
X.M. Fielmich-Bouman ◽  
B.A. van Oost ◽  
A.C. Beynen ◽  
...  
Keyword(s):  
Quantitative Trait ◽  
Copper Content ◽  
Major Quantitative Trait Locus ◽  
Genetic Variance ◽  
Inbred Strains ◽  
Chromosome 2 ◽  
Hepatic Copper ◽  
Liver Copper ◽  
Animal Liver ◽  
Trait Locus

Significant differences in liver copper content have been observed between rat inbred strains. To define loci controlling this trait, the offspring (n = 190) from an (LEW/OlaHsd × BC/CpbU) F2-intercross was genetically analyzed. From each F2 animal, liver copper content was determined and genomic DNA was screened with polymorphic DNA markers. We found a major quantitative trait locus (QTL) for liver copper content in females on chromosome 2 and in males on chromosome 10. Both QTLs accounted for approximately 20% of the genetic variance. In addition, suggestive linkage for liver copper content was found on rat chromosomes 1, 8, 10, 12, 14, and 19. The regions on these chromosomes contain genes that are responsible for 9.0–15.5% of the genetic variance of liver copper content.

scholarly journals Effects of dietary copper supplementation of rats on the occurrence of metallothionein-I in liver and its secretion into blood, bile and urine

1986 ◽  
Vol 235 (3) ◽  
pp. 735-739 ◽  
Author(s):  
I Bremner ◽  
R K Mehra ◽  
J N Morrison ◽  
A M Wood
Keyword(s):  
Copper Content ◽  
Degradation Products ◽  
Dietary Copper ◽  
Hepatic Copper ◽  
Liver Copper ◽  
Copper Supplementation

The appearance and excretion of metallothionein-I (MT-I) was studied in rats given a diet containing 1000 mg of Cu/kg for several weeks. No significant increase in MT-I concentrations in liver, plasma or bile was detected in rats with liver copper concentrations less than 600 micrograms of Cu/g fresh wt. Above this concentration, liver MT-I concentrations increased in proportion to the increase in hepatic copper content. Plasma and bile MT-I concentrations were directly related to those in the liver and were about 10 times those in normal rats. Urinary MT-I concentration also increased 10-fold within 1 week. Fractionation of bile and urine on Sephadex G-50 revealed the presence of monomeric MT-I and a range of possible degradation products of the isoprotein.

EFFECTS OF ENVIRONMENTAL TEMPERATURE AND DIETARY COPPER ON GROWTH AND LIPID METABOLISM IN PIGS. I. GROWTH, CARCASS QUALITY, AND TISSUE COPPER LEVELS

1973 ◽  
Vol 53 (1) ◽  
pp. 115-120 ◽  
Author(s):  
A. W. MYRES ◽  
J. P. BOWLAND
Keyword(s):  
Copper Content ◽  
Environmental Temperature ◽  
Carcass Quality ◽  
Growth Data ◽  
Promoting Effect ◽  
Dietary Copper ◽  
Liver Copper ◽  
Copper Supplementation ◽  
Liver And Kidney ◽  
Growth Promoting

An experiment was conducted to compare the effects of 0 or 250 ppm supplemental dietary copper added to a barley–herring meal diet on growth, carcass quality, and tissue copper levels in pigs kept under different environmental conditions. The pigs were kept during winter either outside (−14.5 C), with unheated colony houses for shelter (−0.4 C), or in a heated barn (15 C). Growth data indicated that the performance of pigs kept in the heated barn was superior (P < 0.01) to that of pigs kept outside. Dietary copper appeared to have some growth-promoting effect under both types of environment, but the overall effect was not significant (P < 0.05). There were significant (P < 0.001) increases in the copper content of the liver and kidney due to dietary copper with a trend toward lower liver copper levels in these organs in pigs kept under outside conditions. There was an improvement in carcass quality associated with copper supplementation with no interaction between diet and environment.

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