Rocuronium infusion requirements and plasma concentrations at constant levels of neuromuscular paralysis during three phases of liver transplantation

2003 ◽  
Vol 15 (4) ◽  
pp. 257-266 ◽  
Author(s):  
Ling Gao ◽  
Iqbal Ramzan ◽  
Barry Baker
Keyword(s):  
Liver Transplantation ◽  
Plasma Concentrations ◽  
Neuromuscular Paralysis ◽  
Three Phases

scholarly journals Effects of Endothelin-1 on Hepatic Blood Flow

HPB Surgery ◽  
1996 ◽  
Vol 9 (3) ◽  
pp. 153-159 ◽  
Author(s):  
Kjetil Unneberg ◽  
Marianne Mjaaland ◽  
Elin Helseth ◽  
Arthur Revhaug
Keyword(s):  
Liver Transplantation ◽  
Blood Flow ◽  
Portal Vein ◽  
Plasma Concentrations ◽  
Hepatic Clearance ◽  
Elevated Plasma ◽  
Central Venous ◽  
Portal Vein Pressure ◽  
Portal Vein Flow ◽  
Endothelin 1

Endothelin-1 belongs to a family of potent vasoconstrictors, recently isolated from endothelial cells. Endothelin-1 has a variety of hepatic effects and hepatic clearance from the circulation is important. Elevated plasma concentrations of Endothelin-1 are found after orthotopic liver transplantation and in cirrhosis with ascites.This study in piglets on hepatic bloodflow was designed to compare differences in effects between central venous and intraportal injection of endothelin-1, and to evaluate effects of repeated injections. Central venous injection of endothelin-1 caused a larger reduction in portal vein flow, while intraportal injection caused a larger increase in portal vein pressure. Repeated injections resulted in a reduction in portal vein flow and an increase in portal vein vascular resistance.

Miniature ponies: 2. Endocrinology of the oestrous cycle

2008 ◽  
Vol 20 (3) ◽  
pp. 386 ◽  
Author(s):  
O. J. Ginther ◽  
M. A. Beg ◽  
A. P. Neves ◽  
R. C. Mattos ◽  
B. P. L. Petrucci ◽  
...  
Keyword(s):  
Maximum Concentration ◽  
Luteal Phase ◽  
Plasma Concentrations ◽  
Oestrous Cycle ◽  
Slow Increase ◽  
Lh Surge ◽  
Ovulatory Follicle ◽  
The Future ◽  
Three Phases

Plasma concentrations of FSH, LH, oestradiol and progesterone were studied daily during 12 interovulatory intervals and 21 periovulatory periods in nine Miniature ponies. The peak of the FSH surge that was temporally associated with emergence of the future ovulatory follicle occurred when the follicle was ~9 mm, compared with a reported diameter of 13 mm in larger breeds. The ovulatory LH surge involved a slow increase between Days 13 and 18 (ovulation = Day 0; 0.6 ± 0.1 ng day–1), a minimal increase or a plateau on Days 18 to 21 (0.04 ± 0.1 ng day–1), and a rapid increase after Day 21 (2.2 ± 0.4 ng day–1; P < 0.0001). The end of the plateau and the beginning of the rapid increase occurred on the day of maximum concentration in the oestradiol preovulatory surge. An unexpected mean increase and decrease in LH occurred (P < 0.04) on Days 5 to 9. Concentrations of oestradiol and progesterone seemed similar to reported results in larger breeds. Results indicated that in Miniature ponies the peak of the FSH surge associated with emergence of the future ovulatory follicle occurred at a smaller diameter of the future ovulatory follicle than in larger breeds, the ovulatory LH surge increased in three phases, and the ovulatory LH surge was followed by an LH increase and decrease during the early luteal phase.

Plasma concentrations of flumazenil during liver transplantation

Anaesthesia ◽  
1992 ◽  
Vol 47 (10) ◽  
pp. 887-889 ◽  
Author(s):  
G. R. Park ◽  
B. I. Podkowik ◽  
F. Hoffmann-La
Keyword(s):  
Liver Transplantation ◽  
Plasma Concentrations

scholarly journals Stress burden related to postreperfusion syndrome may aggravate hyperglycemia with insulin resistance during living donor liver transplantation: A propensity score-matching analysis

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243873
Author(s):  
Sumin Chae ◽  
Junghee Choi ◽  
Sujin Lim ◽  
Ho Joong Choi ◽  
Jaesik Park ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Liver Transplantation ◽  
Propensity Score ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Plasma Concentrations ◽  
Donor Liver ◽  
C Peptide ◽  
Donor Liver Transplantation ◽  
The Impact

Background We investigated the impact of postreperfusion syndrome (PRS) on hyperglycemia occurrence and connecting (C) peptide release, which acts as a surrogate marker for insulin resistance, during the intraoperative period after graft reperfusion in patients undergoing living donor liver transplantation (LDLT) using propensity score (PS)-matching analysis. Patients and methods Medical records from 324 adult patients who underwent elective LDLT were retrospectively reviewed, and their data were analyzed according to PRS occurrence (PRS vs. non-PRS groups) using the PS-matching method. Intraoperative levels of blood glucose and C-peptide were measured through the arterial or venous line at each surgical phase. Hyperglycemia was defined as a peak glucose level >200 mg/dL, and normal plasma concentrations of C-peptide in the fasting state were taken to range between 0.5 and 2.0 ng/mL. Results After PS matching, there were no significant differences in pre- and intra-operative recipient findings and donor-graft findings between groups. Although glucose and C-peptide levels continuously increased through the surgical phases in both groups, glucose and C-peptide levels during the neohepatic phase were significantly higher in the PRS group than in the non-PRS group, and larger changes in levels were observed between the preanhepatic and neohepatic phases. There were higher incidences of C-peptide levels >2.0 ng/mL and peak glucose levels >200 mg/dL in the neohepatic phase in patients with PRS than in those without. PRS adjusted for PS with or without exogenous insulin infusion was significantly associated with hyperglycemia occurrence during the neohepatic phase. Conclusions Elucidating the association between PRS and hyperglycemia occurrence will help with establishing a standard protocol for intraoperative glycemic control in patients undergoing LDLT.

Release of Neopterin, PMN Elastase and Terminal Complement Complexes by Orthotopic Liver Transplantation with and without the Use of Veno-venous Bypass

Pteridines ◽  
1998 ◽  
Vol 9 (1) ◽  
pp. 1-7
Author(s):  
H. Tomasdottir ◽  
E. Rønholm ◽  
JP Bengtson ◽  
A. Bengtsson
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Plasma Concentrations ◽  
Venous Bypass ◽  
Pmn Elastase ◽  
Arterial Blood ◽  
Neopterin Concentration ◽  
Pmn Élastase ◽  
Terminal Complement Complexes ◽  
Terminal Complement

Summary Aim: The aim of the study was to determine whether orthotopic liver transplantation leads to the activation of macrophages, neutrophils and complement. Patients and methods: Twenty-four patients undergoing orthotopic liver transplantation were studied. 12 were operated on with and 12 without the use of a veno-venous bypass. Blood samples for neopterin, PMN elastase and terminal complement complex (SC5b-9) determinations were drawn preoperatively, 1 minute before perfusion of the grafted liver and 2-5 and 30-60 minutes after the start of perfusion of the grafted liver. Comparisons were made between patients with or withour a veno-venous bypass and with or without postreperfusion syndrome (PRS) . PRS was defined as hypotension with ≥30% reduction of systemic mean arterial blood pressure during at least 1 minute after reperfusion of the grafted liver. Results: Release of neopterin was observed 2-5 and 30-60 minutes after the start of perfusion of the grafted liver in patients operated upon with and without the use of a veno-venous bypass. There were no significant differences in neopterin concentration between patients developing PRS and those without circulatory instability. Increased PMN elastase and SC5b-9 concentrations (p<0.05) were found 2-5 and 30-60 minutes after the start of reperfusion in both patients operated upon with and without a veno-venous bypass. The plasma concentrations of neopterin, PMN elastase and SC5b-9 were higher in patients with PRS compared with those without (p<0.05, respectively). Comments: This study indicates that orthotopic liver transplantation leads to the activation of macrophages, neutrophils and the complement cascade. There is no major difference regarding the activation between patients operated upon with and without the use of a veno-venous bypass.

scholarly journals Delta-Like Canonical Notch Ligand 1 in Patients Following Liver Transplantation—A Secondary Analysis of a Prospective Cohort Study

Diagnostics ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 894
Author(s):  
Sebastian O. Decker ◽  
Dagmar Hildebrand ◽  
Thomas Bruckner ◽  
Christoph Lichtenstern ◽  
Klaus Heeg ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Bacterial Infection ◽  
Bacterial Infections ◽  
Plasma Concentrations ◽  
Secondary Analysis ◽  
Composite Endpoint ◽  
Observation Time ◽  
Diagnostic Methods ◽  
Notch Ligand ◽  
Patients At Risk

Opportunistic bacterial infections are dreaded risks in patients following liver transplantation (LTX), even though patients receive an antibiotic prophylaxis. The timely recognition of such an infection may be delayed, as culture-based diagnostic methods are linked with a relevant gap in performance. We measured plasma concentrations of Delta-like canonical Notch ligand 1 (DLL1) in 93 adult patients at seven consecutive time points after liver transplantation and correlated the results to the occurrence of culture-proven bacterial infection or a complicated clinical course (composite endpoint of two or more complications: graft rejection or failure, acute kidney failure, acute lung injury, or 90-day mortality). Patients exhibited elevated plasma concentrations after liver transplantation over the whole 28 d observation time. Patients with bacterial infection showed increased DLL1 levels compared to patients without infection. Persistent elevated levels of DLL1 on day 7 and afterward following LTX were able to indicate patients at risk for a complicated course. Plasma levels of DLL1 following LTX may be useful to support an earlier detection of bacterial infections in combination with C-reactive protein (CRP) and procalcitonin (PCT), or they may lead to risk stratification of patients as a single marker for post-operative complications. (Clinical Trial Notation. German Clinical Trials Register: DRKS00005480).

Sign in / Sign up

Export Citation Format

Share Document