scholarly journals Long-term treatment of asthmatic patients with salmeterol vs slow-release theophylline

1998 ◽  
Vol 92 (4) ◽  
pp. 683-690 ◽  
Author(s):  
S. Nutini ◽  
T. Martini ◽  
R. Righi
Keyword(s):  
Slow Release ◽  
Term Treatment ◽  
Asthmatic Patients ◽  
Long Term Treatment

Long-term treatment of acromegaly with the slow-release somatostatin analogue lanreotide

1994 ◽  
Vol 131 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Josef Marek ◽  
Václav Hána ◽  
Michal Kršek ◽  
Vlasta Justová ◽  
France Catus ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Slow Release ◽  
Serum Levels ◽  
Term Treatment ◽  
Somatostatin Analogue ◽  
Tumour Mass ◽  
Long Term Treatment ◽  
Active Acromegaly ◽  
One Year

Marek J, Hána V. Kršek M. Justová V, Catus F, Thomas F. Long-term treatment of acromegaly with the slow-release somatostatin analogue lanreotide. Eur J Endocrinol 1994;131:20–6. ISSN 0804–4643 Thirteen patients with active acromegaly despite previous surgery were treated with 30 mg lanreotide im twice a month for 9 months. In 10 subjects the treatment continued to 19 months. GH serum levels of all patients decreased significantly from an initial value of 32.0 (29.4) μg/l [median (standard error of median)] to 10.0 (3.6) and 19.1 (5.7) after 3 and 9 months of treatment, respectively. In the 10 patients with the treatment longer than one year the decrease in GH was from 46.8 (29.4) μg/l to 12.5 (5.0) and 16.1 (5.3) after 13 and 19 months, respectively. IGF-I serum levels decreased significantly from 1193 (73)μg/l to 782 (99) and 621 (103) after 3 and 9 months, respectively, and were normalized in 3 patients. In the 10 patients treated for longer than one year, levels decreased significantly from 1318 (74)μg/l to 653 (170) and 742 (180) after 13 and 19 months, respectively. IGF BP-3 levels were reduced to the normal range in 6 patients and decreased from 8.7 (1.5)mg/l to 6.4 (0.8) and to 5.4 (1.0) after 3 and 9 months, respectively. In the patients with the 19 months treatment the decrease was from 9.3 (1.6) mg/l to 3.9 (0.9) and 4.8 (0.9) after 13 and 19 months, respectively. The IGF BP-3 to IFG I ratio increased in 7 patients. This elevation significantly correlated with the decrease in bioassayable somatomedin. Prolactin serum levels fell in all patients with increased prolactin secretion. Testosterone plasma levels increased in 4 out of 5 men without replacement therapy. Clinical improvement was observed in all patients. A reduction of tumour mass was observed in five patients and complete disappearance of the tumour in one subject. All patients complained of mild abdominal pain and softened stools for several days following the injections. However, these side effects never required interruption of treatment. Asymptomatic microlithiasis was seen in only one patient after 13 months, which led to treatment being suspended for a period of 3 months after which it was resumed. Fasting serum insulin and insulin area under the curve (AUC) after oral glucose tolerance test (OGTT) fell in all patients. Fasting blood glucose, fructosamine and glucose AUC after OGTT slightly increased during the treatment, but all blood glucose levels (fasting and during OGTT) remained within normal ranges. Lanreotide appears to be a safe and effective treatment in patients with active acromegaly unresolved by surgery. The long-acting formulation avoids the drawbacks associated with either repeated daily injections or continuous infusions of somatostatin analogues. Josef Marek, Third Department of Medicine, Charles University, U nemocnice 1, 128 21 Praha 2, The Czech Republic

scholarly journals Final height in central precocious puberty after long term treatment with a slow release GnRH agonist.

1996 ◽  
Vol 75 (4) ◽  
pp. 292-297 ◽  
Author(s):  
W Oostdijk ◽  
B Rikken ◽  
S Schreuder ◽  
B Otten ◽  
R Odink ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Gnrh Agonist ◽  
Slow Release ◽  
Final Height ◽  
Central Precocious Puberty ◽  
Term Treatment ◽  
Long Term Treatment

scholarly journals Severe Allergic Bronchopulmonary Mycosis and Long-Term Follow-Up

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Hossein Esmaeilzadeh ◽  
Sara Kashef ◽  
Hamid Reza Hatami ◽  
Soheila Alyasin ◽  
Hesamodin Nabavizadeh ◽  
...  
Keyword(s):  
Immunoglobulin E ◽  
Allergic Bronchopulmonary Aspergillosis ◽  
Fungal Species ◽  
Term Treatment ◽  
High Resolution Computed Tomography ◽  
Asthmatic Patients ◽  
Long Term Treatment ◽  
Allergic Bronchopulmonary Mycosis ◽  
Fungal Allergen

Allergic bronchopulmonary aspergillosis (ABPA) is the most common immunologic reaction following fungal allergen exposure in asthmatic patients. A less frequent syndrome in response to other fungal species like candida is allergic bronchopulmonary mycosis (ABPM). This reaction is mostly associated with asthma exacerbation, changes in Immunoglobulin E levels, and nonspecific findings in high resolution computed tomography (HRCT). This study presents a 9-year-old girl, a known case of childhood asthma, resolved 4 years ago as a novel case of ABPM due to Candida albicans manifested by severe emphysema, bronchiectasis, and pneumothorax which consequently required long-term treatment to get relieved.

Long-Term Treatment with Slow-Release Frusemide Compared with Thiazide Treatment in Arterial Hypertension

1989 ◽  
Vol 17 (6) ◽  
pp. 552-559 ◽  
Author(s):  
H. Jørgensen ◽  
N. Anderssen ◽  
T. Silsand ◽  
L.-E. Peterson
Keyword(s):  
Arterial Hypertension ◽  
Antihypertensive Effect ◽  
Slow Release ◽  
Serum Glucose ◽  
Term Treatment ◽  
Moderate Essential Hypertension ◽  
Fasting Serum ◽  
Long Term Treatment ◽  
Previously Treated

The effect of 30 mg/day slow-release frusemide given orally for 12 months was studied in 64 patients previously treated with thiazides for mild to moderate essential hypertension. Frusemide had a significant antihypertensive effect ( P<0.001), and compared to thiazides significantly reduced fasting serum glucose ( P<0.015), haemoglobin A1c ( P<0.025), albumin ( P<0.025) and serum calcium ( P<0.025), and significantly increased serum sodium and chloride concentrations ( P<0.0001). There was also a non-significant trend for frusemide to reduce serum total cholesterol, triglycerides and urate, and to increase serum potassium. Frusemide was well tolerated in all but three patients. It is concluded that slow-release frusemide has a comparable antihypertensive effect to that of thiazide diuretics, but has fewer metabolic side-effects, and should be used in preference to thiazides for the treatment of arterial hypertension when a diuretic is indicated.

scholarly journals Long-term effects of deslorelin implants on reproduction in the female tammar wallaby (Macropus eugenii)

Reproduction ◽  
2005 ◽  
Vol 129 (3) ◽  
pp. 361-369 ◽  
Author(s):  
C A Herbert ◽  
T E Trigg ◽  
M B Renfree ◽  
G Shaw ◽  
D C Eckery ◽  
...  
Keyword(s):  
Gnrh Agonist ◽  
Slow Release ◽  
Tammar Wallaby ◽  
Term Treatment ◽  
Long Term Effects ◽  
Macropus Eugenii ◽  
Reproductive Management ◽  
Long Term Treatment ◽  
Negative Side Effects

The contraceptive and endocrine effects of long-term treatment with implants containing the GnRH agonist deslorelin were investigated in female tammar wallabies (Macropus eugenii). Fertility was successfully inhibited for 515 ± 87 days after treatment with a 5 mg deslorelin implant (n= 7), while control animals gave birth to their first young 159 ± 47 days after placebo implant administration (n= 8). The duration of contraception was highly variable, ranging from 344 to 761 days. The strict reproductive seasonality in the tammar wallaby was maintained once the implant had expired. This inhibition of reproduction was associated with a significant reduction in basal LH concentrations and a cessation of oestrous cycles, as evidenced by low progesterone concentrations. There was evidence to suggest that some aspect of either blastocyst survival, luteal reactivation, pregnancy or birth may be affected by deslorelin treatment in some animals. These results show that long-term inhibition of fertility in the female tammar wallaby is possible using slow-release deslorelin implants. The effects of deslorelin treatment were fully reversible and there was no evidence of negative side effects. Slow-release GnRH agonist implants may represent a practicable method for reproductive management of captive and semi-wild populations of marsupials.

Nocturia in Patients on Long-Term Steroid Therapy

1970 ◽  
Vol 38 (4) ◽  
pp. 415-425 ◽  
Author(s):  
J. P. Thomas ◽  
G. A. Coles ◽  
A. H. El-Shaboury
Keyword(s):  
Circadian Rhythm ◽  
Term Treatment ◽  
Tubular Reabsorption ◽  
Electrolyte Excretion ◽  
Asthmatic Patients ◽  
Long Term Treatment ◽  
Proximal Tubular ◽  
Stopping Treatment ◽  
Proximal Tubular Reabsorption

1. About half of our asthmatic patients on long-term treatment with prednisone developed nocturia. 2. This is due to reversal of the normal circadian rhythm of water and electrolyte excretion and is partially corrected within 48 hr of stopping treatment. 3. The disturbance in water and electrolyte excretion appeared to be due to a decrease in proximal tubular reabsorption of sodium at night. This was not directly related to a change in the secretion of Cortisol, aldosterone or antidiuretic hormone.

Sustamycin and tetrabid: slow-release tetracyclines

1972 ◽  
Vol 10 (16) ◽  
pp. 63-64
Keyword(s):  
Renal Function ◽  
Special Interest ◽  
Slow Release ◽  
Acne Vulgaris ◽  
Tetracycline Resistance ◽  
Term Treatment ◽  
Impair Renal Function ◽  
Long Term Treatment ◽  
In Pregnancy

The tetracyclines are effective antibiotics for the treatment of exacerbations of chronic bronchitis and are also extensively used for the long-term treatment of acne vulgaris. Their more general use has, however, diminished because of an increasing incidence of tetracycline resistance among many formerly susceptible bacteria and because their effects on developing teeth contraindicate their use in pregnancy and childhood. Moreover in patients with pyelonephritis tetracyclines may further impair renal function.1 New tetracyclines are of special interest if they have any advantage over existing preparations in these respects.

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