A high-density poly(ethylene glycol) polymer brush for immobilization on glass-type surfaces

2000 ◽  
Vol 15 (9-10) ◽  
pp. 473-481 ◽  
Author(s):  
Jacob Piehler ◽  
Andreas Brecht ◽  
Ramūnas Valiokas ◽  
Bo Liedberg ◽  
Günter Gauglitz
Keyword(s):  
Ethylene Glycol ◽  
Polymer Brush ◽  
High Density ◽  
Poly Ethylene Glycol ◽  
Glass Type ◽  
Poly Ethylene

Glass Surfaces Grafted with High-Density Poly(ethylene glycol) as Substrates for DNA Oligonucleotide Microarrays

Langmuir ◽  
2006 ◽  
Vol 22 (1) ◽  
pp. 277-285 ◽  
Author(s):  
Robert Schlapak ◽  
Patrick Pammer ◽  
David Armitage ◽  
Rong Zhu ◽  
Peter Hinterdorfer ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
High Density ◽  
Oligonucleotide Microarrays ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Glass Surfaces

Two-Dimensional Array Formation of Multi-Cellular Spheroids on Micro-Patterned Polymer Brush Surface

2005 ◽  
Vol 288-289 ◽  
pp. 449-452
Author(s):  
H. Otsuka ◽  
T. Satomi ◽  
A. Hirano ◽  
Y. Nagasaki ◽  
Kazunori Kataoka
Keyword(s):  
Endothelial Cells ◽  
Ethylene Glycol ◽  
Physiological Response ◽  
Polymer Brush ◽  
Two Dimensional ◽  
Poly Ethylene Glycol ◽  
Cellular Spheroids ◽  
Glass Substrates ◽  
Poly Ethylene ◽  
Hepatocyte Spheroids

Here, a two-dimensional microarray of ten thousand (100x100) hepatocyte hetero-spheroids, underlaid with endothelial cells, was successfully constructed with a 100 µm spacing in an active area of 20x20 mm on micro-fabricated glass substrates coated with poly(ethylene glycol) (PEG) brushes (Fig. 1). Co-cultivation of hepatocytes with endothelial cells was essential to stabilize hepatocyte viability and liver-specific functions, allowing us to obtain hepatocyte spheroids with a diameter of 100 µm, functioning as a miniaturized liver to secret albumin for at least three weeks. The spheroid array constructed here is highly useful as a platform of TBB and CBB to detect a wide variety of clinically, pharmacologically, and toxicologically active compounds through a cellular physiological response.

Grafting of High-Density Poly(Ethylene Glycol) Monolayers on Si(111)

Langmuir ◽  
2001 ◽  
Vol 17 (25) ◽  
pp. 7798-7803 ◽  
Author(s):  
X.-Y. Zhu ◽  
Y. Jun ◽  
D. R. Staarup ◽  
R. C. Major ◽  
S. Danielson ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
High Density ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Synthesis and Surface Morphology of High-Density Poly(ethylene glycol) Grafted Layers

Langmuir ◽  
2003 ◽  
Vol 19 (24) ◽  
pp. 10179-10187 ◽  
Author(s):  
Bogdan Zdyrko ◽  
Viktor Klep ◽  
Igor Luzinov
Keyword(s):  
Surface Morphology ◽  
Ethylene Glycol ◽  
High Density ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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