Clinical Value of Dual-energy CT in Detection of Pancreatic Adenocarcinoma: Investigation of the Best Pancreatic Tumor Contrast to Noise Ratio

2012 ◽  
Vol 27 (4) ◽  
pp. 207-212 ◽  
Author(s):  
Yong-lan He ◽  
Da-ming Zhang ◽  
Hua-dan Xue ◽  
Zheng-yu Jin
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Pancreatic Tumor ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Clinical Value ◽  
Noise Ratio

scholarly journals Threshold-dependent iodine imaging and spectral separation in a whole-body photon-counting CT system

2021 ◽  
Author(s):  
S. Sawall ◽  
L. Klein ◽  
E. Wehrse ◽  
L. T. Rotkopf ◽  
C. Amato ◽  
...  
Keyword(s):  
Image Quality ◽  
Photon Counting ◽  
Dual Energy ◽  
Whole Body ◽  
Dual Energy Ct ◽  
Post Mortem ◽  
Tube Voltage ◽  
Spectral Separation ◽  
Dual Source ◽  
Noise Ratio

Abstract Objective To evaluate the dual-energy (DE) performance and spectral separation with respect to iodine imaging in a photon-counting CT (PCCT) and compare it to dual-source CT (DSCT) DE imaging. Methods A semi-anthropomorphic phantom extendable with fat rings equipped with iodine vials is measured in an experimental PCCT. The system comprises a PC detector with two energy bins (20 keV, T) and (T, eU) with threshold T and tube voltage U. Measurements using the PCCT are performed at all available tube voltages (80 to 140 kV) and threshold settings (50–90 keV). Further measurements are performed using a conventional energy-integrating DSCT. Spectral separation is quantified as the relative contrast media ratio R between the energy bins and low/high images. Image noise and dose-normalized contrast-to-noise ratio (CNRD) are evaluated in resulting iodine images. All results are validated in a post-mortem angiography study. Results R of the PC detector varies between 1.2 and 2.6 and increases with higher thresholds and higher tube voltage. Reference R of the EI DSCT is found as 2.20 on average overall phantoms. Maximum CNRD in iodine images is found for T = 60/65/70/70 keV for 80/100/120/140 kV. The highest CNRD of the PCCT is obtained using 140 kV and is decreasing with decreasing tube voltage. All results could be confirmed in the post-mortem angiography study. Conclusion Intrinsically acquired DE data are able to provide iodine images similar to conventional DSCT. However, PCCT thresholds should be chosen with respect to tube voltage to maximize image quality in retrospectively derived image sets. Key Points • Photon-counting CT allows for the computation of iodine images with similar quality compared to conventional dual-source dual-energy CT. • Thresholds should be chosen as a function of the tube voltage to maximize iodine contrast-to-noise ratio in derived image sets. • Image quality of retrospectively computed image sets can be maximized using optimized threshold settings.

scholarly journals Clinical Value of Energy Spectrum Curves of Dual-energy CT in Evaluating Pathological Grading of Gastric Adenocarcinoma

2019 ◽  
Author(s):  
Zhihua Lu ◽  
Suying Wu ◽  
Jianwei Chen ◽  
Chuan Yan ◽  
Yueming Li
Keyword(s):  
Gastric Cancer ◽  
Energy Spectrum ◽  
Gastric Adenocarcinoma ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Clinical Value ◽  
Pathological Differentiation ◽  
Dual Source ◽  
Venous Phase ◽  
Poorly Differentiated

Abstract Backgroud: Accurate diagnosis of cancer staging and pathological differentiation are critical for the formulation of individualized treatment and prognosis of gastric cancer. It is vital to explore non-invasive preoperative imaging techniques to evaluate the pathological differentiation degree of gastric cancer tissues, and provide better diagnostic basis and decision-making reference for treatment. The purpose of this study was to explore the clinical value of energy spectrum curves of dual-source dual-energy CT in the quantitative evaluation of different pathological grades of gastric adenocarcinoma. Methods: A total of 62 patients with 1 well, 25 moderately and 36 poorly differentiated gastric adenocarcinomas pathologically confirmed by surgery were collected, and they underwent dual-source dual-energy CT plain scanning and enhanced scanning before operation. Dual-Energy software was used to measure the slope of the energy spectrum curves (λ) in arterial and venous phases after image reconstruction. Patients were divided into two groups according to the pathological results, including well and moderately differentiated gastric adenocarcinoma group and poorly differentiated gastric adenocarcinoma group. Data of each group were analyzed by independent sample t-test. The receiver operating characteristic curve was plotted to evaluate the diagnostic efficiency of the corresponding parameters. Results: There were significant differences in λ values of 40-50keV, 40-60keV, 40-80keV, 40-90keV, 40-100keV, 40-120keV, 40-130keV, 40-140keV and 40-150keV energy ranges in venous phase between the well and moderately differentiated group and poorly differentiated group (P<0.05), but no significant differences in λ values of different energy ranges in arterial phase between the two groups (P>0.05). And the area under curve in 40-120keV energy range was the largest in venous phase. K40-120keV =2.69 was selected as the diagnostic threshold with the maximum Youden index, the sensitivity and specificity were 61.1% and 76%, respectively. Conclusion: The energy spectrum curve of dual-energy CT had certain diagnostic value in the quantitative evaluation of pathological grading of gastric adenocarcinoma.

Role of rapid kV-switching dual-energy CT in assessment of post-surgical local recurrence of pancreatic adenocarcinoma

2017 ◽  
Vol 43 (2) ◽  
pp. 497-504 ◽  
Author(s):  
Anushri Parakh ◽  
Manuel Patino ◽  
Daniela Muenzel ◽  
Avinash Kambadakone ◽  
Dushyant V. Sahani
Keyword(s):  
Local Recurrence ◽  
Pancreatic Adenocarcinoma ◽  
Dual Energy ◽  
Dual Energy Ct

scholarly journals Salvage of Suboptimal Enhancement of Pulmonary Artery in Pulmonary CT Angiography Studies: Rapid kVp Switch Dual Energy CT Experience

2020 ◽  
Vol 17 (2) ◽  
Author(s):  
Selen Bayraktaroglu ◽  
Akın Cinkooglu ◽  
Naim Ceylan ◽  
Recep Savas
Keyword(s):  
Pulmonary Embolism ◽  
Image Quality ◽  
Pulmonary Artery ◽  
Imaging Modality ◽  
Main Pulmonary Artery ◽  
Pulmonary Arteries ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Average Increase ◽  
Noise Ratio

Background: Multidetector computed tomography (MDCT) angiography is considered as the gold standard imaging modality in the evaluation of acute pulmonary embolism. Optimum vascular enhancement is critical for MDCT studies. The suboptimal opacification in pulmonary artery could be salvaged using low-energy virtual monoenergetic images (VMI) at rapid kVp switch dual energy CT. Objectives: To explore the potential improvement in pulmonary artery opacification and to assess the change in image quality parameters in VMI using fast switch kVp dual energy CT. Patients and Methods: The CT images of 877 patients who were referred with a preliminary diagnosis of pulmonary embolism were reviewed. Sixty patients with suboptimal enhancement (< 200 Hounsfeld Unit [HU]) were involved. Standard images (140 kVp) and VMI from 40 to 120 keV were generated. Attenuation, noise, signal to noise ratio (SNR) and contrast to noise ratio (CNR) were measured in the pulmonary artery. Using VMIs, the best image was determined as the image with the main pulmonary artery opacification greater than 200 HU and image quality ≥ 3. Fifty six studies that met these criteria were considered as salvaged. At this best energy level, quantitative parameters were compared with standard images. Results: The mean attenuation of pulmonary arteries was 169.80 HU in standard images in patients with suboptimal enhancement. The attenuations of VMIs at 40, 45, 50, 55, 60, 65, and 70 keV were significantly higher than standard images (P < 0.001). Similar findings were observed with SNR and CNR. In the salvaged patients, the average increase in mean pulmonary artery attenuation was 62% (from 172.61 ± 23.4 to 280.55 ± 40.7), the average increase in SNR was 38% (from 12.1 ± 5.3 to 16.7 ± 7.1) and the average increase in CNR was 48% (9.2 ± 4.3 to 13.7 ± 6) (P < 0.001). Conclusions: Low keV VMI reconstructions significantly increase pulmonary artery attenuation, CNR and SNR compared to standard image reconstructions. Suboptimal CT studies could be salvaged using low keV VMIs.

Comparison of noise-optimized linearly blended images and noise-optimized virtual monoenergetic images evaluated by dual-source, dual-energy CT in cardiac vein assessment

2020 ◽  
pp. 028418512093324
Author(s):  
Gyeong Min Kim ◽  
Ki Seok Choo ◽  
Jin Hyeok Kim ◽  
Jae-Yeon Hwang ◽  
Chan Kyu Park ◽  
...  
Keyword(s):  
Dual Energy ◽  
Venous System ◽  
Treatment Modalities ◽  
Dual Energy Ct ◽  
Great Cardiac Vein ◽  
Coronary Venous System ◽  
Virtual Monoenergetic Images ◽  
Image Set ◽  
Noise Ratio ◽  
Monoenergetic Images

Background The coronary venous system is frequently used as an entry route to the heart and treatment modalities for many cardiac diseases and many procedures. Consequently, evaluation of the coronary venous system and understanding cardiac vein anatomy is crucial. Purpose To determine the optimal image set in a comparison of noise-optimized linearly blended images (F_0.6) and noise-optimized virtual monoenergetic images (VMI+) evaluated by dual-energy computed tomography (DECT) for cardiac vein assessment. Material and Methods Thirty-four patients (mean age 58.2 ± 14.2 years) who underwent DECT due to chest pain were enrolled. Images were post-processed with the F_0.6, and VMI+ algorithms at energy levels in the range of 40–100 keV in 10-keV increments. Enhancement (HU), noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) were objectively measured at two points in the great cardiac vein by consensus of two radiologists. Two blinded observers evaluated the subjective image quality of the great cardiac vein on a 4-point scale. Results HU, noise, and SNR peaked at 40 keV VMI+ ( P < 0.05) among 50–100 keV VMI+. CNR peaked at 100 keV VMI+; however, there were no significant differences compared to CNR images processed at 40–90 keV VMI+. HU and noise were significantly higher in 40 keV VMI+ than F_0.6 images; however, both SNR and CNR were significantly higher in F_0.6 images. An assessment of subjective vein delineation revealed that F_0.6 images had the highest scores Conclusion F_0.6 images were superior to VMI+ and provided the optimal image set for cardiac vein assessment.

Machine-learning based comparison of CT-perfusion maps and dual energy CT for pancreatic tumor detection

2016 ◽  
Author(s):  
Michael Goetz ◽  
Stephan Skornitzke ◽  
Christian Weber ◽  
Franziska Fritz ◽  
Philipp Mayer ◽  
...  
Keyword(s):  
Machine Learning ◽  
Pancreatic Tumor ◽  
Ct Perfusion ◽  
Tumor Detection ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Perfusion Maps

scholarly journals Diagnosis of Pulmonary Artery Embolism: Comparison of Single-Source CT and 3rd Generation Dual-Source CT using a Dual-Energy Protocol Regarding Image Quality and Radiation Dose

2017 ◽  
Vol 189 (06) ◽  
pp. 527-536 ◽  
Author(s):  
Bernhard Petritsch ◽  
Aleksander Kosmala ◽  
Tobias Gassenmaier ◽  
Andreas Weng ◽  
Simon Veldhoen ◽  
...  
Keyword(s):  
Image Quality ◽  
Radiation Dose ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Dual Source Ct ◽  
Single Source ◽  
Subjective Image Quality ◽  
Artery Embolism ◽  
Dual Source ◽  
Noise Ratio

Purpose To compare radiation dose, subjective and objective image quality of 3 rd generation dual-source CT (DSCT) and dual-energy CT (DECT) with conventional 64-slice single-source CT (SSCT) for pulmonary CTA. Materials and Methods 180 pulmonary CTA studies were performed in three patient cohorts of 60 patients each. Group 1: conventional SSCT 120 kV (ref.); group 2: single-energy DSCT 100 kV (ref.); group 3: DECT 90/Sn150 kV. CTDIvol, DLP, effective radiation dose were reported, and CT attenuation (HU) was measured on three central and peripheral levels. The signal-to-noise-ratio (SNR) and contrast-to-noise-ratio (CNR) were calculated. Two readers assessed subjective image quality according to a five-point scale. Results Mean CTDIvol and DLP were significantly lower in the dual-energy group compared to the SSCT group (p < 0.001 [CTDIvol]; p < 0.001 [DLP]) and the DSCT group (p = 0.003 [CTDIvol]; p = 0.003 [DLP]), respectively. The effective dose in the DECT group was 2.79 ± 0.95 mSv and significantly smaller than in the SSCT group (4.60 ± 1.68 mSv, p < 0.001) and the DSCT group (4.24 ± 2.69 mSv, p = 0.003). The SNR and CNR were significantly higher in the DSCT group (p < 0.001). Subjective image quality did not differ significantly among the three protocols and was rated good to excellent in 75 % (135/180) of cases with an inter-observer agreement of 80 %. Conclusion Dual-energy pulmonary CTA protocols of 3 rd generation dual-source scanners allow for significant reduction of radiation dose while providing excellent image quality and potential additional information by means of perfusion maps. Key Points: Citation Format

Dual-energy CT of pancreatic adenocarcinoma: reproducibility of primary tumor measurements and assessment of tumor conspicuity and margin sharpness

2016 ◽  
Vol 41 (7) ◽  
pp. 1317-1324 ◽  
Author(s):  
Shiva Gupta ◽  
Nicolaus Wagner-Bartak ◽  
Corey T. Jensen ◽  
Anthony Hui ◽  
Wei Wei ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Primary Tumor ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Tumor Measurements

Dual energy CT in pulmonary vascular disease

2021 ◽  
pp. 20210699
Author(s):  
Ioannis Vlahos ◽  
Megan C Jacobsen ◽  
Myrna C Godoy ◽  
Konstantinos Stefanidis ◽  
Rick R Layman
Keyword(s):  
Pulmonary Hypertension ◽  
Chronic Thromboembolic Pulmonary Hypertension ◽  
Vascular Diseases ◽  
Lung Parenchyma ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Pulmonary Vascular Disease ◽  
Clinical Value ◽  
Current Application ◽  
Care Protocol

Dual energy CT (DECT) imaging is a technique that extends the capabilities of CT beyond that of established densitometric evaluations. CT pulmonary angiography (CTPA) performed with dual energy technique benefits from both the availability of low kVp CT data and also the concurrent ability to quantify iodine enhancement in the lung parenchyma. Parenchymal enhancement, presented as pulmonary perfused blood volume maps, may be considered a surrogate of pulmonary perfusion. These distinct capabilities have led to new opportunities in the evaluation of pulmonary vascular diseases. Dual energy CTPA offers the potential for improvements in pulmonary emboli detection, diagnostic confidence, and most notably severity stratification. Furthermore, the appreciated insights of pulmonary vascular physiology conferred by DECT have resulted in increased use for the assessment of pulmonary hypertension, with particular utility in the subset of patients with chronic thromboembolic pulmonary hypertension. With the increasing availability of dual energy-capable CT systems, dual energy CTPA is becoming a standard-of-care protocol for CTPA acquisition in acute PE. Furthermore, qualitative and quantitative pulmonary vascular DECT data heralds promise for the technique as a “one-stop shop” for diagnosis and surveillance assessment in patients with pulmonary hypertension. This review explores the current application, clinical value, and limitations of DECT imaging in acute and chronic pulmonary vascular conditions. It should be noted that certain manufacturers and investigators prefer alternative terms, such as spectral or multi energy CT imaging. In this review the term dual energy is utilised, although readers can consider these terms synonymous for purposes of the principles explained.

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