A novel alpha2-adrenoceptor antagonist attenuates the early, but preserves the late cardiovascular effects of intravenous dexmedetomidine in conscious dogs

1998 ◽  
Vol 12 (4) ◽  
pp. 429-434 ◽  
Author(s):  
Paul S. Pagel ◽  
Lester T. Proctor ◽  
Anton Devcic ◽  
Douglas A. Hettrick ◽  
Judy R. Kersten ◽  
...  
Keyword(s):  
Cardiovascular Effects ◽  
Conscious Dogs ◽  
Adrenoceptor Antagonist ◽  
Alpha2 Adrenoceptor

scholarly journals The selectivity of DG-5128 as a new alpha2-adrenoceptor antagonist

1984 ◽  
Vol 36 ◽  
pp. 243
Author(s):  
Kyozo Yamanaka ◽  
Masafumi Oshita ◽  
Shigeru Kigoshi ◽  
Ikunobu Muramatsu
Keyword(s):  
Adrenoceptor Antagonist ◽  
Alpha2 Adrenoceptor

CGS 7525A, A new, centrally active alpha2 adrenoceptor antagonist

Life Sciences ◽  
1983 ◽  
Vol 32 (4) ◽  
pp. 355-363 ◽  
Author(s):  
Jeffrey M. Liebman ◽  
Richard A. Lovell ◽  
Albert Braunwalder ◽  
George Stone ◽  
Patrick Bernard ◽  
...  
Keyword(s):  
Adrenoceptor Antagonist ◽  
Alpha2 Adrenoceptor

Evidence for activation of both adrenergic and cholinergic nervous pathways by yohimbine, an alpha2-adrenoceptor antagonist

1995 ◽  
Vol 9 (3) ◽  
pp. 248-254 ◽  
Author(s):  
H. Bagheri ◽  
JJ Chale ◽  
LN Guyen ◽  
MA Tran ◽  
M. Berlan ◽  
...  
Keyword(s):  
Adrenoceptor Antagonist ◽  
Alpha2 Adrenoceptor

scholarly journals Analysis of the cardiovascular effects of arginine vasopressin in conscious dogs.

Hypertension ◽  
1987 ◽  
Vol 9 (4) ◽  
pp. 371-378 ◽  
Author(s):  
U Tipayamontri ◽  
D B Young ◽  
B S Nuwayhid ◽  
R E Scott
Keyword(s):  
Arginine Vasopressin ◽  
Cardiovascular Effects ◽  
Conscious Dogs

INFLUENCE OF ADRENERGIC SYSTEM ON LIDOCAINE AND BUPIVACAINK CARDIOVASCULAR EFFECTS IN CONSCIOUS DOGS

1985 ◽  
Vol 63 (Supplement) ◽  
pp. A224 ◽  
Author(s):  
R. FROIDEVAUX ◽  
A. EDOUARD ◽  
A. BERDEAUX ◽  
J. LANGLOYS ◽  
K. SAMII
Keyword(s):  
Cardiovascular Effects ◽  
Conscious Dogs ◽  
Adrenergic System

Involvement of CB1-receptors and β-adrenoceptors in the regional hemodynamic responses to lipopolysaccharide infusion in conscious rats

2005 ◽  
Vol 288 (5) ◽  
pp. H2280-H2288 ◽  
Author(s):  
S. M. Gardiner ◽  
J. E. March ◽  
P. A. Kemp ◽  
T. Bennett
Keyword(s):  
Cardiovascular Effects ◽  
The Other ◽  
Cb1 Receptors ◽  
Sprague Dawley ◽  
Hemodynamic Changes ◽  
Hemodynamic Responses ◽  
Adrenoceptor Antagonist ◽  
Sprague Dawley Rats ◽  
Chronic Model ◽  
Vasodilator Action

A possible involvement of endocannabinoids in a chronic model of endotoxemia was assessed by measuring the regional (renal, mesenteric, hindquarters) hemodynamic responses to continuous 24-h LPS infusion (150 μg·kg−1·h−1) in conscious, male Sprague-Dawley rats, in the absence or presence of the cannabinoid (CB1) receptor antagonist AM-251 (3 mg/kg). AM-251 inhibited the tachycardic and hindquarters vasodilator effects of LPS, but did not influence the other hemodynamic changes. In subsequent experiments, it was shown that the tachycardic and hindquarters vasodilator effects of LPS were also inhibited by the nonselective β-adrenoceptor antagonist propranolol. In addition, the late (at 24 h) hindquarters vasodilator effects of LPS were inhibited by the β2-adrenoceptor antagonist ICI-118551. Against the background of our previous work showing β-adrenoceptor involvement in the cardiovascular effects of exogenous cannabinoids, we conclude that AM-251 may have been inhibiting endocannabinoid-modulated, sympathoadrenal-mediated activation of vasodilator β-adrenoceptors in LPS-infused rats rather than suppressing a direct vasodilator action of endocannabinoids.

Cardiovascular Effects of Vasopressin Infused into the Vertebral Circulation of Conscious Dogs

1981 ◽  
Vol 61 (3) ◽  
pp. 345-347 ◽  
Author(s):  
J. F. Liard ◽  
O. Dériaz ◽  
M. Tschopp ◽  
J. Schoun
Keyword(s):  
Heart Rate ◽  
Arterial Pressure ◽  
Inferior Vena ◽  
Vena Cava ◽  
Electromagnetic Flowmeter ◽  
Cardiovascular Effects ◽  
Conscious Dogs ◽  
Left Vertebral Artery ◽  
Plasma Vasopressin ◽  
The Central Nervous System

1. Seven conscious dogs received arginine-vasopressin infusions (100 and 1000 fmol min−1 kg−1) through catheters implanted in the left vertebral artery or the inferior vena cava while arterial pressure, cardiac output (electromagnetic flowmeter) and heart rate were measured. 2. Despite similar increases in plasma vasopressin concentrations, intravertebral administration induced a lesser increase in mean arterial pressure and a greater decrease in heart rate than the same infusion given intravenously. 3. These results suggest that vasopressin has an effect on structures of the central nervous system involved in cardiovascular control, possibly by affecting the baroreceptor reflex.

scholarly journals The Alpha2-Adrenoceptor Antagonist Dexefaroxan Enhances Hippocampal Neurogenesis by Increasing the Survival and Differentiation of New Granule Cells

2005 ◽  
Vol 31 (6) ◽  
pp. 1146-1157 ◽  
Author(s):  
Pamela Rizk ◽  
Julio Salazar ◽  
Rita Raisman-Vozari ◽  
Marc Marien ◽  
Merle Ruberg ◽  
...  
Keyword(s):  
Granule Cells ◽  
Hippocampal Neurogenesis ◽  
Adrenoceptor Antagonist ◽  
Alpha2 Adrenoceptor
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